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Gene: CTRL (chymotrypsin like) Pan paniscus

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Symbol:

CTRL

Name:

chymotrypsin like

RGD ID:

11854781

Description:

ENCODES a protein that exhibits serine-type peptidase activity (ortholog); INVOLVED IN proteolysis (ortholog); ASSOCIATED WITH autosomal dominant dyskeratosis congenita 6 (ortholog); Chromosome 16q12 Duplication Syndrome (ortholog); long QT syndrome (ortholog); FOUND IN extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

chymotrypsin-like protease CTRL-1; chymotrypsin-like protease CTRL-1-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CTRL (chymotrypsin like)	NCBI	Ortholog
Mus musculus (house mouse):	Ctrl (chymotrypsin-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ctrl (chymotrypsin-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ctrl (chymotrypsin like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CTRL (chymotrypsin like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ctrl (chymotrypsin like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CTRL (chymotrypsin like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CTRL (chymotrypsin like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ctrl (chymotrypsin like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	77,456,564 - 77,460,908 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	83,367,990 - 83,370,113 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	48,270,961 - 48,274,248 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	67,658,148 - 67,661,410 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	67,658,451 - 67,660,582 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant dyskeratosis congenita 6 (ISO)

Chromosome 16q12 Duplication Syndrome (ISO)

long QT syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteolysis (IEA,ISO)

Cellular Component

extracellular space (IEA)

Molecular Function

peptidase activity (IEA)

protein binding (ISO)

serine-type endopeptidase activity (IEA)

serine-type peptidase activity (IEA,ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

CTRL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	77,456,564 - 77,460,908 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	83,367,990 - 83,370,113 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	48,270,961 - 48,274,248 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	67,658,148 - 67,661,410 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	67,658,451 - 67,660,582 (-)	Ensembl	panpan1.1		panPan2

CTRL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	67,929,574 - 67,931,862 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	67,927,640 - 67,932,365 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	67,963,477 - 67,965,765 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	66,520,974 - 66,523,266 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	66,520,974 - 66,523,266	NCBI
Celera	16	52,471,930 - 52,474,222 (-)	NCBI		Celera
Cytogenetic Map	16	q22.1	NCBI
HuRef	16	53,837,043 - 53,839,348 (-)	NCBI		HuRef
CHM1_1	16	69,371,652 - 69,373,957 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	73,725,348 - 73,727,636 (-)	NCBI		T2T-CHM13v2.0

Ctrl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	106,658,626 - 106,660,494 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	106,658,635 - 106,660,494 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	105,931,994 - 105,933,862 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	105,932,003 - 105,933,862 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	108,455,894 - 108,457,762 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	108,820,789 - 108,822,991 (-)	NCBI		MGSCv36	mm8
Celera	8	110,160,042 - 110,161,910 (-)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI
cM Map	8	53.06	NCBI

Ctrl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	50,737,078 - 50,740,659 (-)	NCBI		GRCr8
mRatBN7.2	19	33,827,279 - 33,829,129 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	33,827,229 - 33,833,626 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	40,642,815 - 40,644,665 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	41,296,130 - 41,297,980 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	43,594,680 - 43,596,530 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	37,905,864 - 37,907,714 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	37,905,864 - 37,907,714 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	48,772,599 - 48,775,409 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	35,774,031 - 35,775,881 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	35,778,911 - 35,780,759 (-)	NCBI
Celera	19	33,254,828 - 33,256,678 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

Ctrl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955484	8,781,928 - 8,783,929 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955484	8,781,928 - 8,783,929 (+)	NCBI	ChiLan1.0	ChiLan1.0

CTRL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	81,565,155 - 81,567,472 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	81,565,418 - 81,567,472 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	81,554,912 - 81,557,457 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	82,000,253 - 82,002,798 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	82,000,740 - 82,003,005 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	81,826,462 - 81,829,007 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	81,508,592 - 81,511,137 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	82,150,811 - 82,153,356 (+)	NCBI		UU_Cfam_GSD_1.0

Ctrl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	41,299,179 - 41,302,980 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	18,286,133 - 18,288,091 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	18,284,495 - 18,288,938 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CTRL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	28,540,808 - 28,542,773 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	28,540,187 - 28,542,820 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CTRL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	59,508,058 - 59,510,392 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	59,508,380 - 59,510,330 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	22,234,344 - 22,235,738 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ctrl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	18,447,574 - 18,449,964 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	18,447,042 - 18,449,888 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003812169	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063597667	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000050251 ⟹ ENSPPAP00000027411

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	16	67,658,451 - 67,660,582 (-)	Ensembl

RefSeq Acc Id:

XM_003812169 ⟹ XP_003812217

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	77,456,564 - 77,458,690 (-)	NCBI
NHGRI_mPanPan1	16	83,367,990 - 83,370,113 (-)	NCBI
Mhudiblu_PPA_v0	16	48,270,961 - 48,274,248 (-)	NCBI
PanPan1.1	16	67,658,148 - 67,660,582 (-)	NCBI

Sequence:

show sequence

TCAGGGGACCTTGGCCTAAAGGGCCTGTCTTGCCTGGAGCGTGGGAGGGGGCTGAGTCTACACA
GCTGGCCTGGCCTCAGGCCTGGAGCTTTAGCTCAAGGACGAGAAGACCCATAAAGCCAGACCCA
GCTCCCAACCTCACATCTGCCACGATGTTGCTGCTCAGCCTGACCCTAAGCCTGGTTCTCCTCG
GCTCCTCCTGGGGCTGCGGCATTCCTGCCATCAAACCGGCACTGAGCTTCAGCCAGAGGATTGT
CAACGGGGAGAATGCAGTGTCGGGCTCCTGGCCCTGGCAGGTGTCCCTGCAGGACAGCAGCGGC
TTCCACTTCTGCGGTGGTTCTCTCATCAGCCAGTCCTGGGTGGTCACTGCTGCCCACTGCAATG
TCAGCCCTGGCCGCCATTTTGTTGTCCTGGGCGAGTATGACCGATCATCAAACGCAGAGCCCTT
GCAGGTTCTGTCCATCTCTCGGGCCATTACACACCCTAGCTGGAACTCTACCACCATGAACAAT
GACGTGACGCTGCTGAAGGTCGCCTCGCCAGCCCAGTACACAACACGCATCTCGCCAATTTGCC
TGGCATCCTCAAACGAGGCTCTGACTGAAGGCCTCACGTGTGTCACCACCGGCTGGGGTCGCCT
CAGTGGCGTGGGCAATGTGACACCAGCACGTCTGCAGCAGGTGGCTTTGCCCCTGGTCACTGTG
AATCAGTGCCGGCAGTACTGGGGCTCAAGTATCACTGACTCCATGATCTGTGCAGGTGGCGCAG
GTGCCTCCTCGTGCCAGGGTGACTCCGGAGGCCCTCTTGTCTGCCAGAAGGGAAACACATGGGT
GCTTATTGGTATTGTCTCCTGGGGCACCAAAAACTGCAATGTGCGCGCACCTGCTGTCTATACT
CGAGTTAGCAAGTTCAGCACCTGGATCAACCAGGTCATAGCCTACAACTGAGCTCACCACAGGC
CCCTCCCCAGCTCAACCCATTAAAGACCCAGGCCCTGTCCCATCATGCATTCATGTCTGTCTTC
CTGGCTCAGGAGAAAGAAGAGGCTGTTGAGGGTCCGACTCCCTACTTGGACTTCTGGCACAGAA
GGGGCTGAGTGACTCCTTGAGTAGCAGTGGCTCTTCCTAGAGTAGCCATGCCCAGGCCGGGGCC
CCCACCCCTCCTCCAGGGCAACCCCTTGGTCCTACAGCAAGAAGCCAGAACTGTTGGAATGAAT
GGCAGCCCTCCCTGGAGAGGCAGCCTGTTTACTGAATACAGAGGATACGTTTACAAACTGAATA
CGCATAATAAATAACTGCACATTCTCCATCCA

hide sequence

RefSeq Acc Id:

XM_063597667 ⟹ XP_063453737

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	77,456,564 - 77,460,908 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003812217	(Get FASTA)	NCBI Sequence Viewer
	XP_063453737	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000027411
	ENSPPAP00000027411.1

RefSeq Acc Id:	XP_003812217 ⟸ XM_003812169
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9BGK5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLLLSLTLSLVLLGSSWGCGIPAIKPALSFSQRIVNGENAVSGSWPWQVSLQDSSGFHFCGGSL ISQSWVVTAAHCNVSPGRHFVVLGEYDRSSNAEPLQVLSISRAITHPSWNSTTMNNDVTLLKVA SPAQYTTRISPICLASSNEALTEGLTCVTTGWGRLSGVGNVTPARLQQVALPLVTVNQCRQYWG SSITDSMICAGGAGASSCQGDSGGPLVCQKGNTWVLIGIVSWGTKNCNVRAPAVYTRVSKFSTW INQVIAYN hide sequence

Ensembl Acc Id:

ENSPPAP00000027411 ⟸ ENSPPAT00000050251

RefSeq Acc Id:	XP_063453737 ⟸ XM_063597667
- Peptide Label:	isoform X1

Protein Domains

Peptidase S1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000036784	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000050251.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
InterPro	Peptidase_S1_PA	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
KEGG Report	pps:100975743	UniProtKB/TrEMBL
NCBI Gene	CTRL	ENTREZGENE
PANTHER	CHYMOTRYPSIN-LIKE PROTEASE CTRL-1	UniProtKB/TrEMBL
	CHYMOTRYPSIN-RELATED	UniProtKB/TrEMBL
Pfam	Trypsin	UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
SMART	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50494	UniProtKB/TrEMBL
UniProt	A0A2R9BGK5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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