ZBTB7A (zinc finger and BTB domain containing 7A) - Rat Genome Database

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Gene: ZBTB7A (zinc finger and BTB domain containing 7A) Pan paniscus
Analyze
Symbol: ZBTB7A
Name: zinc finger and BTB domain containing 7A
RGD ID: 11852594
Description: ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor binding (ortholog); nuclear androgen receptor binding (ortholog); INVOLVED IN chromatin remodeling (ortholog); fat cell differentiation (ortholog); negative regulation of androgen receptor signaling pathway (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); amenorrhea (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); DNA-dependent protein kinase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: zinc finger and BTB domain-containing protein 7A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2208,440,492 - 8,466,499 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,670,621 - 7,694,593 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,066,554 - 3,090,285 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,013,208 - 4,037,630 (-)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ZBTB7ABonoboamenorrhea  ISOZBTB7A (Homo sapiens)8554872ClinVar Annotator: match by term: Primary amenorrheaClinVarPMID:21681106
ZBTB7ABonobogenetic disease  ISOZBTB7A (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
ZBTB7ABonoboMACROCEPHALY, NEURODEVELOPMENTAL DELAY, LYMPHOID HYPERPLASIA, AND PERSISTENT FETAL HEMOGLOBIN  ISOZBTB7A (Homo sapiens)8554872ClinVar Annotator: match by term: Macrocephaly more ...ClinVarPMID:25741868 more ...
ZBTB7ABonoboRASopathy  ISOZBTB7A (Homo sapiens)8554872ClinVar Annotator: match by term: RASopathyClinVarPMID:23379592 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ZBTB7ABonoboacute myeloid leukemia  ISOZBTB7A (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:27798625
ZBTB7ABonoboglioblastoma  ISOZBTB7A (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:25875864
ZBTB7ABonoboProstatic Neoplasms  ISOZBTB7A (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:23727861
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ZBTB7ABonoboMACROCEPHALY, NEURODEVELOPMENTAL DELAY, LYMPHOID HYPERPLASIA, AND PERSISTENT FETAL HEMOGLOBIN  ISOZBTB7A (Homo sapiens)7240710 OMIM 


Biological Process
1 to 20 of 23 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ZBTB7ABonoboB cell differentiation involved_inIEAUniProtKB:O88939 and ensembl:ENSMUSP00000047333150520179 EnsemblGO_REF:0000107
ZBTB7ABonobochromatin organization involved_inIEAUniProtKB:O88939 and ensembl:ENSMUSP00000047333150520179 EnsemblGO_REF:0000107
ZBTB7ABonobochromatin remodeling involved_inISOZBTB7A (Homo sapiens)9068941 PMID:26816381UniProtPMID:26816381
ZBTB7ABonoboDNA-templated transcription involved_inIEAUniProtKB:O88939 and ensembl:ENSMUSP00000047333150520179 EnsemblGO_REF:0000107
ZBTB7ABonobodouble-strand break repair via classical nonhomologous end joining involved_inIEAUniProtKB:O88939 and ensembl:ENSMUSP00000047333150520179 EnsemblGO_REF:0000107
ZBTB7ABonoboerythrocyte maturation involved_inIEAUniProtKB:O88939 and ensembl:ENSMUSP00000047333150520179 EnsemblGO_REF:0000107
ZBTB7ABonobofat cell differentiation involved_inISOZBTB7A (Homo sapiens)9068941 PMID:14701838UniProtPMID:14701838
ZBTB7ABonobonegative regulation of androgen receptor signaling pathway involved_inISOZBTB7A (Homo sapiens)9068941 PMID:20812024UniProtPMID:20812024
ZBTB7ABonobonegative regulation of DNA-templated transcription involved_inIEAUniProtKB:O88939 and ensembl:ENSMUSP00000047333150520179 EnsemblGO_REF:0000107
ZBTB7ABonobonegative regulation of Notch signaling pathway involved_inIEAUniProtKB:O88939 and ensembl:ENSMUSP00000047333150520179 EnsemblGO_REF:0000107
ZBTB7ABonobonegative regulation of transcription by RNA polymerase II involved_inISOZbtb7a (Mus musculus)9068941 PMID:15337766NTNU_SBPMID:15337766
ZBTB7ABonobonegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinIEAUniProtKB:O88939 and ensembl:ENSMUSP00000047333150520179 EnsemblGO_REF:0000107
ZBTB7ABonobonegative regulation of transcription by RNA polymerase II involved_inISOZBTB7A (Homo sapiens)9068941 PMID:20812024UniProtPMID:20812024
ZBTB7ABonobonegative regulation of transforming growth factor beta receptor signaling pathway involved_inISOZBTB7A (Homo sapiens)9068941 PMID:25514493UniProtPMID:25514493
ZBTB7ABonobopositive regulation of NF-kappaB transcription factor activity involved_inISOZBTB7A (Homo sapiens)9068941 PMID:15917220UniProtPMID:15917220
ZBTB7ABonoboprotein localization to nucleus involved_inISOZBTB7A (Homo sapiens)9068941 PMID:15917220UniProtPMID:15917220
ZBTB7ABonoboregulation of alternative mRNA splicing, via spliceosome involved_inISOZBTB7A (Homo sapiens)9068941 PMID:24514149UniProtPMID:24514149
ZBTB7ABonoboregulation of apoptotic process involved_inISOZBTB7A (Homo sapiens)9068941 PMID:24514149UniProtPMID:24514149
ZBTB7ABonoboregulation of DNA-binding transcription factor activity involved_inISOZbtb7a (Mus musculus)9068941 PMID:29813070UniProtPMID:29813070
ZBTB7ABonoboregulation of DNA-templated transcription  ISOZbtb7a (Rattus norvegicus)9068941 RGDPMID:10477728 and REF_RGD_ID:633299
1 to 20 of 23 rows

Cellular Component

  

Molecular Function
1 to 20 of 24 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
ZBTB7ABonoboDNA binding enablesIEAUniProtKB:O88939 and ensembl:ENSMUSP00000047333150520179 EnsemblGO_REF:0000107
ZBTB7ABonoboDNA-binding transcription factor activity  ISOZbtb7a (Rattus norvegicus)9068941 RGDPMID:10477728 and REF_RGD_ID:633299
ZBTB7ABonoboDNA-binding transcription factor activity enablesIEAUniProtKB:O88939 and ensembl:ENSMUSP00000047333150520179 EnsemblGO_REF:0000107
ZBTB7ABonoboDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAPANTHER:PTN008703918150520179 TreeGrafterGO_REF:0000118
ZBTB7ABonoboDNA-binding transcription factor binding enablesISOUniProtKB:P080479068941 PMID:12004059UniProtPMID:12004059
ZBTB7ABonoboDNA-binding transcription repressor activity, RNA polymerase II-specific enablesIEAUniProtKB:O88939 and ensembl:ENSMUSP00000047333150520179 EnsemblGO_REF:0000107
ZBTB7ABonobohistone acetyltransferase binding enablesIEAUniProtKB:O88939 and ensembl:ENSMUSP00000047333150520179 EnsemblGO_REF:0000107
ZBTB7ABonobonuclear androgen receptor binding enablesISOZBTB7A (Homo sapiens)9068941 PMID:20812024UniProtPMID:20812024
ZBTB7ABonobonuclear androgen receptor binding enablesISOUniProtKB:P102759068941 PMID:20812024UniProtPMID:20812024
ZBTB7ABonoboprotein binding enablesISOUniProtKB:Q042069068941 PMID:15917220UniProtPMID:15917220
ZBTB7ABonoboprotein binding enablesISOUniProtKB:O091069068941 PMID:15337766 and PMID:26816381IntActPMID:15337766 and PMID:26816381
ZBTB7ABonoboprotein binding enablesISOUniProtKB:Q12873 more ...9068941 PMID:26816381IntActPMID:26816381
ZBTB7ABonoboprotein binding enablesISOUniProtKB:Q07666 and UniProtKB:Q135479068941 PMID:24514149IntActPMID:24514149
ZBTB7ABonoboprotein binding enablesISOUniProtKB:Q042079068941 PMID:29813070UniProtPMID:29813070
ZBTB7ABonoboprotein binding enablesISOUniProtKB:Q8IX15-39068941 PMID:25416956IntActPMID:25416956
ZBTB7ABonoboRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIEAUniProtKB:O88939 and ensembl:ENSMUSP00000047333150520179 EnsemblGO_REF:0000107
ZBTB7ABonoboRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIEAPANTHER:PTN008703918150520179 TreeGrafterGO_REF:0000118
ZBTB7ABonobosequence-specific DNA binding enablesIEAUniProtKB:O88939 and ensembl:ENSMUSP00000047333150520179 EnsemblGO_REF:0000107
ZBTB7ABonobosequence-specific double-stranded DNA binding enablesISOZBTB7A (Homo sapiens)9068941 PMID:28473536ARUK-UCLPMID:28473536
ZBTB7ABonoboSMAD binding enablesISOZBTB7A (Homo sapiens)9068941 PMID:25514493UniProtPMID:25514493
1 to 20 of 24 rows

PMID:22301074   PMID:30032202  



ZBTB7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2208,440,492 - 8,466,499 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,670,621 - 7,694,593 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,066,554 - 3,090,285 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,013,208 - 4,037,630 (-)NCBIpanpan1.1PanPan1.1panPan2
ZBTB7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,043,303 - 4,066,899 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,043,303 - 4,066,899 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,043,301 - 4,066,897 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,996,216 - 4,017,816 (-)NCBINCBI36Build 36hg18NCBI36
Build 34193,996,216 - 4,017,816NCBI
Celera193,984,710 - 4,006,260 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef193,809,524 - 3,824,110 (-)NCBIHuRef
CHM1_1194,044,801 - 4,066,422 (-)NCBICHM1_1
T2T-CHM13v2.0194,026,415 - 4,050,025 (-)NCBIT2T-CHM13v2.0
Zbtb7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,971,113 - 80,988,056 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,971,054 - 80,988,829 (+)EnsemblGRCm39 Ensembl
GRCm381081,135,225 - 81,152,222 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,135,220 - 81,152,995 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,599,016 - 80,614,402 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,539,400 - 80,554,393 (+)NCBIMGSCv36mm8
Celera1082,156,627 - 82,172,013 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Zbtb7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,211,733 - 9,229,273 (-)NCBIGRCr8
mRatBN7.278,561,015 - 8,578,243 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,563,779 - 8,576,539 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,448,841 - 11,461,603 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,324,328 - 13,337,091 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,190,783 - 11,203,558 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,429,266 - 11,446,119 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,432,049 - 11,444,786 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,596,630 - 11,613,467 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,047,586 - 10,060,456 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,047,608 - 10,052,982 (-)NCBI
Celera76,751,640 - 6,757,036 (-)NCBICelera
Cytogenetic Map7q11NCBI
Zbtb7a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,740,901 - 4,753,992 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,747,905 - 4,754,066 (+)NCBIChiLan1.0ChiLan1.0
ZBTB7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,517,531 - 55,527,071 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,505,916 - 55,523,736 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,233,807 - 55,252,980 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,169,484 - 56,187,224 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,166,283 - 56,182,676 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,224,406 - 55,243,571 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,705,817 - 55,724,966 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,904,666 - 55,923,869 (+)NCBIUU_Cfam_GSD_1.0
Zbtb7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,512,758 - 215,525,208 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,311,727 - 2,321,372 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,310,975 - 2,321,790 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZBTB7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,681,193 - 74,694,869 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,678,293 - 74,699,347 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2275,223,154 - 75,243,600 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZBTB7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,802,171 - 3,824,552 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl63,801,046 - 3,812,884 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660814,418,198 - 4,441,462 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zbtb7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,530,543 - 5,545,902 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,529,351 - 5,548,481 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






RefSeq Acc Id: XM_034945762   ⟹   XP_034801653
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2208,440,492 - 8,466,499 (-)NCBI
NHGRI_mPanPan1197,670,621 - 7,694,593 (-)NCBI
Mhudiblu_PPA_v0193,066,554 - 3,090,285 (-)NCBI
RefSeq Acc Id: XM_034945763   ⟹   XP_034801654
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2208,440,492 - 8,462,758 (-)NCBI
NHGRI_mPanPan1197,670,621 - 7,692,875 (-)NCBI
Mhudiblu_PPA_v0193,066,554 - 3,088,783 (-)NCBI
RefSeq Acc Id: XM_034945764   ⟹   XP_034801655
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2208,440,492 - 8,462,212 (-)NCBI
NHGRI_mPanPan1197,673,905 - 7,692,325 (-)NCBI
Mhudiblu_PPA_v0193,066,554 - 3,088,250 (-)NCBI
RefSeq Acc Id: XM_034945765   ⟹   XP_034801656
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2208,440,492 - 8,453,898 (-)NCBI
NHGRI_mPanPan1197,673,905 - 7,684,028 (-)NCBI
Mhudiblu_PPA_v0193,066,554 - 3,079,860 (-)NCBI
Protein RefSeqs XP_034801653 (Get FASTA)   NCBI Sequence Viewer  
  XP_034801654 (Get FASTA)   NCBI Sequence Viewer  
  XP_034801655 (Get FASTA)   NCBI Sequence Viewer  
  XP_034801656 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000036534.1
RefSeq Acc Id: XP_034801653   ⟸   XM_034945762
- UniProtKB: A0A2R9C425 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034801654   ⟸   XM_034945763
- UniProtKB: A0A2R9C425 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034801655   ⟸   XM_034945764
- UniProtKB: A0A2R9C425 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034801656   ⟸   XM_034945765
- UniProtKB: A0A2R9C425 (UniProtKB/TrEMBL)
BTB   C2H2-type



1 to 22 of 22 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSPPAG00000041020 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000059426.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
  Potassium Channel Kv1.1, Chain A UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
  ZnFinger_BTB_dom_contain UniProtKB/TrEMBL
NCBI Gene ZBTB7A ENTREZGENE
PANTHER AGAP004733-PA UniProtKB/TrEMBL
  ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 7A UniProtKB/TrEMBL
Pfam BTB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART BTB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP beta-beta-alpha zinc fingers UniProtKB/TrEMBL
  POZ domain UniProtKB/TrEMBL
UniProt A0A2R9C425 ENTREZGENE, UniProtKB/TrEMBL
1 to 22 of 22 rows