Zbtb7a (zinc finger and BTB domain containing 7a) - Rat Genome Database

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Gene: Zbtb7a (zinc finger and BTB domain containing 7a) Rattus norvegicus
Analyze
Symbol: Zbtb7a
Name: zinc finger and BTB domain containing 7a
RGD ID: 620946
Description: Enables DNA-binding transcription factor activity. Involved in regulation of DNA-templated transcription and regulation of osteoclast differentiation. Located in nucleus. Orthologous to human ZBTB7A (zinc finger and BTB domain containing 7A); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: leukemia/lymphoma related factor; leukemia/lymphoma-related factor; Lrf; OCZF; osteoclast-derived zinc finger; Zbtb7; zinc finger and BTB domain-containing protein 7A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,561,015 - 8,578,243 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,563,779 - 8,576,539 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,448,841 - 11,461,603 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0713,324,328 - 13,337,091 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0711,190,783 - 11,203,558 (-)NCBIRnor_WKY
Rnor_6.0711,429,266 - 11,446,119 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,432,049 - 11,444,786 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,596,630 - 11,613,467 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,047,586 - 10,060,456 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,047,608 - 10,052,982 (-)NCBI
Celera76,751,640 - 6,757,036 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
DNA-dependent protein kinase complex  (IEA,ISO,ISS)
nucleus  (IDA,ISO)
NuRD complex  (IEA,ISO,ISS)
site of double-strand break  (IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Osteoclast-derived zinc finger (OCZF) protein with POZ domain, a possible transcriptional repressor, is involved in osteoclastogenesis. Kukita A, etal., Blood 1999 Sep 15;94(6):1987-97.
3. Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis. Liu CJ, etal., J Biol Chem. 2004 Nov 5;279(45):47081-91. Epub 2004 Aug 26.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12004059   PMID:14701838   PMID:15662416   PMID:15917220   PMID:17495164   PMID:17595526   PMID:20812024   PMID:24514149   PMID:24772825   PMID:25514493   PMID:26446488   PMID:26455326  
PMID:26816381   PMID:29813070   PMID:35474350  


Genomics

Comparative Map Data
Zbtb7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.278,561,015 - 8,578,243 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,563,779 - 8,576,539 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,448,841 - 11,461,603 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0713,324,328 - 13,337,091 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0711,190,783 - 11,203,558 (-)NCBIRnor_WKY
Rnor_6.0711,429,266 - 11,446,119 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,432,049 - 11,444,786 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,596,630 - 11,613,467 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,047,586 - 10,060,456 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,047,608 - 10,052,982 (-)NCBI
Celera76,751,640 - 6,757,036 (-)NCBICelera
Cytogenetic Map7q11NCBI
ZBTB7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,043,303 - 4,066,899 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl194,043,303 - 4,066,899 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,043,301 - 4,066,897 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,996,216 - 4,017,816 (-)NCBINCBI36Build 36hg18NCBI36
Build 34193,996,216 - 4,017,816NCBI
Celera193,984,710 - 4,006,260 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef193,809,524 - 3,824,110 (-)NCBIHuRef
CHM1_1194,044,801 - 4,066,422 (-)NCBICHM1_1
T2T-CHM13v2.0194,026,415 - 4,050,025 (-)NCBIT2T-CHM13v2.0
Zbtb7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,970,416 - 80,988,056 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,971,054 - 80,988,829 (+)EnsemblGRCm39 Ensembl
GRCm381081,135,225 - 81,152,222 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,135,220 - 81,152,995 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,599,016 - 80,614,402 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,539,400 - 80,554,393 (+)NCBIMGSCv36mm8
Celera1082,156,627 - 82,172,013 (+)NCBICelera
Cytogenetic Map10C1NCBI
Zbtb7a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,740,901 - 4,753,992 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,747,905 - 4,754,066 (+)NCBIChiLan1.0ChiLan1.0
ZBTB7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1194,013,208 - 4,037,630 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0193,066,554 - 3,090,285 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ZBTB7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,517,531 - 55,527,071 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,505,916 - 55,523,736 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,233,807 - 55,252,980 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,169,484 - 56,187,224 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,166,283 - 56,182,676 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,224,406 - 55,243,571 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,705,817 - 55,724,966 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,904,666 - 55,923,869 (+)NCBIUU_Cfam_GSD_1.0
Zbtb7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,512,758 - 215,525,208 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,311,727 - 2,321,372 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365882,310,975 - 2,321,790 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZBTB7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,681,193 - 74,694,869 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,678,293 - 74,699,347 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2275,223,154 - 75,243,600 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZBTB7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,802,171 - 3,824,552 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl63,801,046 - 3,812,884 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660814,418,198 - 4,441,462 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zbtb7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,530,543 - 5,545,902 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,529,351 - 5,548,481 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zbtb7a
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:81
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000027323
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 47 31 19 31 1 3 61 33 32 11 1
Low 11 10 10 10 7 8 13 2 9 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027323   ⟹   ENSRNOP00000027323
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,563,799 - 8,576,539 (-)Ensembl
Rnor_6.0 Ensembl711,432,049 - 11,444,786 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082126   ⟹   ENSRNOP00000073998
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,563,779 - 8,575,536 (-)Ensembl
Rnor_6.0 Ensembl711,432,049 - 11,443,357 (-)Ensembl
RefSeq Acc Id: NM_054002   ⟹   NP_446454
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,563,776 - 8,576,539 (-)NCBI
Rnor_6.0711,432,026 - 11,444,786 (-)NCBI
Rnor_5.0711,596,630 - 11,613,467 (-)NCBI
RGSC_v3.4710,047,586 - 10,060,456 (-)RGD
Celera76,751,640 - 6,757,036 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240836   ⟹   XP_006240898
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,561,015 - 8,575,859 (-)NCBI
Rnor_6.0711,429,266 - 11,444,082 (-)NCBI
Rnor_5.0711,596,630 - 11,613,467 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240837   ⟹   XP_006240899
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,561,015 - 8,576,978 (-)NCBI
Rnor_6.0711,429,266 - 11,445,233 (-)NCBI
Rnor_5.0711,596,630 - 11,613,467 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240838   ⟹   XP_006240900
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,561,015 - 8,578,243 (-)NCBI
Rnor_6.0711,429,266 - 11,446,119 (-)NCBI
Rnor_5.0711,596,630 - 11,613,467 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078296   ⟹   XP_038934224
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.278,561,015 - 8,578,243 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_446454   ⟸   NM_054002
- UniProtKB: G3V8P6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240900   ⟸   XM_006240838
- Peptide Label: isoform X2
- UniProtKB: G3V8P6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240899   ⟸   XM_006240837
- Peptide Label: isoform X2
- UniProtKB: G3V8P6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240898   ⟸   XM_006240836
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6Z3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073998   ⟸   ENSRNOT00000082126
RefSeq Acc Id: ENSRNOP00000027323   ⟸   ENSRNOT00000027323
RefSeq Acc Id: XP_038934224   ⟸   XM_039078296
- Peptide Label: isoform X2
- UniProtKB: G3V8P6 (UniProtKB/TrEMBL)
Protein Domains
BTB   C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZ48-F1-model_v2 AlphaFold Q9QZ48 1-569 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694997
Promoter ID:EPDNEW_R5512
Type:single initiation site
Name:Zbtb7a_2
Description:zinc finger and BTB domain containing 7a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5513  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,443,373 - 11,443,433EPDNEW
RGD ID:13694988
Promoter ID:EPDNEW_R5513
Type:initiation region
Name:Zbtb7a_1
Description:zinc finger and BTB domain containing 7a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5512  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,444,798 - 11,444,858EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620946 AgrOrtholog
BioCyc Gene G2FUF-34997 BioCyc
Ensembl Genes ENSRNOG00000020161 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000027323 ENTREZGENE
  ENSRNOP00000027323.3 UniProtKB/TrEMBL
  ENSRNOP00000073998 ENTREZGENE
  ENSRNOP00000073998.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027323 ENTREZGENE
  ENSRNOT00000027323.6 UniProtKB/TrEMBL
  ENSRNOT00000082126 ENTREZGENE
  ENSRNOT00000082126.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.710.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117107 UniProtKB/Swiss-Prot
NCBI Gene 117107 ENTREZGENE
Pfam BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Zbtb7a PhenoGen
PROSITE BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K6Z3 ENTREZGENE, UniProtKB/TrEMBL
  G3V8P6 ENTREZGENE, UniProtKB/TrEMBL
  Q9QZ48 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Zbtb7a  zinc finger and BTB domain containing 7a      Symbol and Name updated 1299863 APPROVED
2004-09-10 Zbtb7  leukemia/lymphoma related factor  Lrf    Symbol and Name updated 1299863 APPROVED
2002-08-07 Lrf  leukemia/lymphoma related factor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains an N-terminal POZ domain and C-terminal Kruppel-like zinc fingers 633299
gene_expression expressed in osteoclasts and kidney cells 633299