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Gene: LOC100976978 (E3 ubiquitin-protein ligase HERC2) Pan paniscus

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Symbol:

LOC100976978 (Ensembl: HERC2)

Name:

E3 ubiquitin-protein ligase HERC2 (Ensembl:HECT and RLD domain containing E3 ubiquitin protein ligase 2)

RGD ID:

11826136

Description:

ENCODES a protein that exhibits metal ion binding (inferred); SUMO binding (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN negative regulation of Notch signaling pathway (ortholog); neuron differentiation (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH Angelman syndrome (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

HECT and RLD domain containing E3 ubiquitin protein ligase 2; HERC2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	6,961,516 - 7,171,075 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	10,603,053 - 10,812,747 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	1,590,558 - 1,800,023 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	25,535,760 - 25,746,444 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	25,536,483 - 25,746,074 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LOC100976978	Bonobo	Angelman syndrome		ISO	HERC2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Angelman syndrome	ClinVar	PMID:24088041 more ...
LOC100976978	Bonobo	autism spectrum disorder		ISO	HERC2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Autism spectrum disorder	ClinVar	PMID:21844811 more ...
LOC100976978	Bonobo	autistic disorder		ISO	HERC2 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:21681106 more ...
LOC100976978	Bonobo	autosomal recessive intellectual developmental disorder 38		ISO	HERC2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Intellectual developmental disorder and autosomal recessive 38	ClinVar	PMID:23065719 more ...
LOC100976978	Bonobo	Childhood Absence Epilepsy 1		ISO	HERC2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Epilepsy more ...	ClinVar	PMID:26068938 and PMID:28492532
LOC100976978	Bonobo	chromosome 15q11.2 deletion syndrome		ISO	HERC2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Chromosome 15q11-q13 duplication syndrome	ClinVar	PMID:25741868 and PMID:31690835
LOC100976978	Bonobo	Developmental Disabilities		ISO	HERC2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Global developmental delay	ClinVar	PMID:25741868 and PMID:30755392
LOC100976978	Bonobo	Dyskinesias		ISO	HERC2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Involuntary movements	ClinVar	PMID:25741868 and PMID:30755392
LOC100976978	Bonobo	dystonia		ISO	HERC2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Dystonic disorder	ClinVar	PMID:25741868 and PMID:30755392
LOC100976978	Bonobo	exotropia		ISO	HERC2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: concomitant exotropia	ClinVar
LOC100976978	Bonobo	genetic disease		ISO	HERC2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:18442486 more ...
LOC100976978	Bonobo	intellectual disability		ISO	HERC2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Intellectual disability and severe	ClinVar	PMID:25741868
LOC100976978	Bonobo	isolated elevated serum creatine phosphokinase levels		ISO	HERC2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: HYPERCKEMIA and IDIOPATHIC	ClinVar	PMID:25741868 and PMID:30755392
LOC100976978	Bonobo	Muscle Hypotonia		ISO	HERC2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Neonatal hypotonia	ClinVar	PMID:25741868
LOC100976978	Bonobo	Neurodevelopmental Disorders		ISO	HERC2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868
LOC100976978	Bonobo	Paraparesis		ISO	HERC2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Paraparesis	ClinVar	PMID:25741868
LOC100976978	Bonobo	Prader-Willi syndrome		ISO	HERC2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Prader-Willi syndrome	ClinVar	PMID:25741868 more ...
LOC100976978	Bonobo	Rhabdomyolysis		ISO	HERC2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Rhabdomyolysis	ClinVar	PMID:25741868 and PMID:30755392
LOC100976978	Bonobo	schizophrenia		ISO	HERC2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Schizophrenia	ClinVar	PMID:21681106 and PMID:30208311
LOC100976978	Bonobo	Skin/Hair/Eye Pigmentation, Variation In, 1		ISO	HERC2 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:17236130 more ...

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LOC100976978	Bonobo	occupational asthma		ISO	HERC2 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:25918132
LOC100976978	Bonobo	ulcerative colitis		ISO	HERC2 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:18438405

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LOC100976978	Bonobo	autosomal recessive intellectual developmental disorder 38		ISO	HERC2 (Homo sapiens)	7240710		OMIM
LOC100976978	Bonobo	Skin/Hair/Eye Pigmentation, Variation In, 1		ISO	HERC2 (Homo sapiens)	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LOC100976978	Bonobo	DNA damage response	involved_in	IEA	UniProtKB:O95714 and ensembl:ENSP00000261609	150520179		Ensembl	GO_REF:0000107
LOC100976978	Bonobo	negative regulation of Notch signaling pathway	acts_upstream_of_or_within	ISO	Herc2 (Mus musculus)	9068941	PMID:26355680	MGI	PMID:26355680
LOC100976978	Bonobo	neuron differentiation	acts_upstream_of_or_within	ISO	Herc2 (Mus musculus)	9068941	PMID:26355680	MGI	PMID:26355680
LOC100976978	Bonobo	proteasome-mediated ubiquitin-dependent protein catabolic process	involved_in	ISO	Herc2 (Mus musculus)	9068941	PMID:26692333	UniProt	PMID:26692333
LOC100976978	Bonobo	protein ubiquitination	involved_in	IEA	UniProtKB:O95714 and ensembl:ENSP00000261609	150520179		Ensembl	GO_REF:0000107
LOC100976978	Bonobo	protein ubiquitination	involved_in	IEA	InterPro:IPR010606	150520179		InterPro	GO_REF:0000002
LOC100976978	Bonobo	protein ubiquitination	involved_in	IEA	UniPathway:UPA00143	150520179		UniProt	GO_REF:0000041
LOC100976978	Bonobo	spermatogenesis	acts_upstream_of_or_within	ISO	MGI:1857705 and MGI:1857706	9068941	PMID:5565073	MGI	MGI:60224 and PMID:5565073

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LOC100976978	Bonobo	cytoplasm	located_in	IEA	UniProtKB-KW:KW-0963	150520179		UniProt	GO_REF:0000043
LOC100976978	Bonobo	cytoplasm	located_in	IEA	UniProtKB-SubCell:SL-0086	150520179		UniProt	GO_REF:0000044
LOC100976978	Bonobo	cytoplasm	located_in	IEA	UniProtKB:O95714 and ensembl:ENSP00000261609	150520179		Ensembl	GO_REF:0000107
LOC100976978	Bonobo	cytosol	located_in	IEA	UniProtKB:O95714 and ensembl:ENSP00000261609	150520179		Ensembl	GO_REF:0000107
LOC100976978	Bonobo	nucleus	located_in	IEA	UniProtKB:O95714 and ensembl:ENSP00000261609	150520179		Ensembl	GO_REF:0000107
LOC100976978	Bonobo	plasma membrane	located_in	IEA	UniProtKB:O95714 and ensembl:ENSP00000261609	150520179		Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
LOC100976978	Bonobo	metal ion binding	enables	IEA	InterPro:IPR010606 and InterPro:IPR037252	150520179		InterPro	GO_REF:0000002
LOC100976978	Bonobo	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	150520179		UniProt	GO_REF:0000043
LOC100976978	Bonobo	protein binding	enables	ISO	UniProtKB:Q9BXG8	9068941	PMID:35140242	IntAct	PMID:35140242
LOC100976978	Bonobo	protein binding	enables	ISO	PR:Q5NCX5	9068941	PMID:26355680	MGI	PMID:26355680
LOC100976978	Bonobo	protein binding	enables	ISO	UniProtKB:O76064	9068941	PMID:20023648	UniProt	PMID:20023648
LOC100976978	Bonobo	protein binding	enables	ISO	UniProtKB:Q05086-2	9068941	PMID:29426014	IntAct	PMID:29426014
LOC100976978	Bonobo	protein binding	enables	ISO	UniProtKB:Q9NRI5	9068941	PMID:31413325	IntAct	PMID:31413325
LOC100976978	Bonobo	protein binding	enables	ISO	UniProtKB:P23025	9068941	PMID:20304803	IntAct	PMID:20304803
LOC100976978	Bonobo	protein binding	enables	ISO	UniProtKB:Q9BXG8 and UniProtKB:Q9UKA1	9068941	PMID:28514442	IntAct	PMID:28514442
LOC100976978	Bonobo	protein binding	enables	ISO	UniProtKB:P23025 more ...	9068941	PMID:33961781	IntAct	PMID:33961781
LOC100976978	Bonobo	SUMO binding	enables	IEA	UniProtKB:O95714 and ensembl:ENSP00000261609	150520179		Ensembl	GO_REF:0000107
LOC100976978	Bonobo	ubiquitin protein ligase activity	enables	IEA	UniProtKB:O95714 and ensembl:ENSP00000261609	150520179		Ensembl	GO_REF:0000107
LOC100976978	Bonobo	ubiquitin protein ligase binding	enables	IEA	UniProtKB:O95714 and ensembl:ENSP00000261609	150520179		Ensembl	GO_REF:0000107
LOC100976978	Bonobo	ubiquitin-protein transferase activity	enables	IEA	InterPro:IPR000569 more ...	150520179		InterPro	GO_REF:0000002
LOC100976978	Bonobo	zinc ion binding	enables	IEA	UniProtKB-KW:KW-0863	150520179		UniProt	GO_REF:0000043
LOC100976978	Bonobo	zinc ion binding	enables	IEA	InterPro:IPR000433	150520179		InterPro	GO_REF:0000002

PMID:22301074

LOC100976978
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	6,961,516 - 7,171,075 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	10,603,053 - 10,812,747 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	1,590,558 - 1,800,023 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	25,535,760 - 25,746,444 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	25,536,483 - 25,746,074 (-)	Ensembl	panpan1.1		panPan2

HERC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	28,111,040 - 28,322,179 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	28,111,040 - 28,322,179 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	28,356,186 - 28,567,325 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	26,029,781 - 26,240,890 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	26,029,782 - 26,240,845	NCBI
Celera	15	6,513,422 - 6,701,708 (-)	NCBI		Celera
Cytogenetic Map	15	q13.1	NCBI
HuRef	15	6,482,549 - 6,693,549 (-)	NCBI		HuRef
CHM1_1	15	28,305,169 - 28,516,258 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	25,853,561 - 26,064,943 (-)	NCBI		T2T-CHM13v2.0

Herc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	55,699,872 - 55,884,373 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	55,699,944 - 55,881,548 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	56,050,124 - 56,231,800 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	56,050,196 - 56,231,800 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	63,305,525 - 63,487,170 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	55,918,272 - 56,099,815 (+)	NCBI		MGSCv36	mm8
Celera	7	53,391,067 - 53,570,966 (+)	NCBI		Celera
Cytogenetic Map	7	B5	NCBI
cM Map	7	33.42	NCBI

Herc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	116,009,681 - 116,243,888 (+)	NCBI		GRCr8
mRatBN7.2	1	106,904,789 - 107,110,997 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	106,880,084 - 107,108,134 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	112,296,244 - 112,499,217 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	120,768,113 - 120,971,079 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	114,017,071 - 114,220,047 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	114,453,033 - 114,653,787 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	114,453,054 - 114,653,793 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	115,459,325 - 115,658,977 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	107,440,126 - 107,645,117 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	107,518,956 - 107,722,801 (+)	NCBI
Celera	1	101,115,534 - 101,316,349 (+)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

Herc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955533	1,304,675 - 1,489,041 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955533	1,304,675 - 1,489,041 (+)	NCBI	ChiLan1.0	ChiLan1.0

HERC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	31,723,113 - 31,966,061 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	31,723,500 - 31,966,199 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	34,716,991 - 34,960,078 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	32,370,920 - 32,613,992 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	3	31,904,221 - 32,147,887 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	32,153,608 - 32,396,909 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	32,265,346 - 32,508,054 (+)	NCBI		UU_Cfam_GSD_1.0

Herc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	120,571,057 - 120,758,254 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	38,419,129 - 38,606,323 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	38,419,147 - 38,606,312 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HERC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	56,438,148 - 56,649,792 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	56,438,117 - 56,649,805 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	63,528,991 - 63,584,752 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HERC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	53,760,172 - 54,007,356 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	53,792,593 - 54,007,489 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	36,527,151 - 36,805,768 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_034938387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034938388	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034938389	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034938390	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034938391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034938392	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034938393	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034938394	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000040672 ⟹ ENSPPAP00000017951

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	15	25,536,483 - 25,746,074 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000040679 ⟹ ENSPPAP00000017958

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	15	25,724,825 - 25,746,074 (-)	Ensembl

RefSeq Acc Id:

XM_034938387 ⟹ XP_034794278

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	16	6,961,516 - 7,171,075 (+)	NCBI
NHGRI_mPanPan1	15	10,603,059 - 10,812,747 (+)	NCBI
Mhudiblu_PPA_v0	15	1,590,562 - 1,800,023 (+)	NCBI

RefSeq Acc Id:

XM_034938388 ⟹ XP_034794279

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	16	6,961,516 - 7,171,075 (+)	NCBI
NHGRI_mPanPan1	15	10,603,059 - 10,812,747 (+)	NCBI
Mhudiblu_PPA_v0	15	1,590,564 - 1,800,023 (+)	NCBI

RefSeq Acc Id:

XM_034938393 ⟹ XP_034794284

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	16	6,961,516 - 7,171,075 (+)	NCBI
NHGRI_mPanPan1	15	10,603,053 - 10,812,747 (+)	NCBI
Mhudiblu_PPA_v0	15	1,590,558 - 1,800,023 (+)	NCBI


Protein RefSeqs	XP_034794278	(Get FASTA)	NCBI Sequence Viewer
	XP_034794279	(Get FASTA)	NCBI Sequence Viewer
	XP_034794284	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000017951.1
	ENSPPAP00000017958.1

RefSeq Acc Id:	XP_034794284 ⟸ XM_034938393
- Peptide Label:	isoform X3
- UniProtKB:	A0A2R9AKQ7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_034794278 ⟸ XM_034938387
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9AKQ7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_034794279 ⟸ XM_034938388
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9AKQ7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSPPAP00000017951 ⟸ ENSPPAT00000040672

Ensembl Acc Id:

ENSPPAP00000017958 ⟸ ENSPPAT00000040679

Protein Domains

Cytochrome b5 heme-binding DOC HECT MIB/HERC2 ZZ-type

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000031770	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000040672.1	UniProtKB/TrEMBL
	ENSPPAT00000040679.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.30	UniProtKB/TrEMBL
	2.30.30.30	UniProtKB/TrEMBL
	3.10.120.10	UniProtKB/TrEMBL
	3.30.60.90	UniProtKB/TrEMBL
	Galactose-binding domain-like	UniProtKB/TrEMBL
	Hect, E3 ligase catalytic domain	UniProtKB/TrEMBL
	Hect, E3 ligase catalytic domain	UniProtKB/TrEMBL
	Hect, E3 ligase catalytic domains	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
InterPro	APC_su10/DOC_dom	UniProtKB/TrEMBL
	Beta-propeller_rpt_TECPR	UniProtKB/TrEMBL
	CPH_domain	UniProtKB/TrEMBL
	Cyt_B5-like_heme/steroid-bd	UniProtKB/TrEMBL
	Cyt_B5-like_heme/steroid_sf	UniProtKB/TrEMBL
	Galactose-bd-like_sf	UniProtKB/TrEMBL
	HECT_dom	UniProtKB/TrEMBL
	Hect_E3_ubiquitin_ligase	UniProtKB/TrEMBL
	HERC2_APC10	UniProtKB/TrEMBL
	Mib_Herc2	UniProtKB/TrEMBL
	Mib_Herc2_sf	UniProtKB/TrEMBL
	RCC1/BLIP-II	UniProtKB/TrEMBL
	Reg_chr_condens	UniProtKB/TrEMBL
	Rib_L2_dom2	UniProtKB/TrEMBL
	Signaling_Regulatory_Domain	UniProtKB/TrEMBL
	Znf_ZZ	UniProtKB/TrEMBL
	Znf_ZZ_sf	UniProtKB/TrEMBL
	ZZ_HERC2	UniProtKB/TrEMBL
NCBI Gene	HERC2	ENTREZGENE
PANTHER	BTK-BINDING PROTEIN-RELATED	UniProtKB/TrEMBL
	INHIBITOR OF BRUTON TYROSINE KINASE	UniProtKB/TrEMBL
Pfam	ANAPC10	UniProtKB/TrEMBL
	Cul7	UniProtKB/TrEMBL
	Cyt-b5	UniProtKB/TrEMBL
	HECT	UniProtKB/TrEMBL
	MIB_HERC2	UniProtKB/TrEMBL
	PF00569	UniProtKB/TrEMBL
	RCC1	UniProtKB/TrEMBL
PRINTS	RCCNDNSATION	UniProtKB/TrEMBL
PROSITE	CYTOCHROME_B5_2	UniProtKB/TrEMBL
	DOC	UniProtKB/TrEMBL
	HECT	UniProtKB/TrEMBL
	MIB_HERC2	UniProtKB/TrEMBL
	RCC1_2	UniProtKB/TrEMBL
	RCC1_3	UniProtKB/TrEMBL
	ZF_ZZ_1	UniProtKB/TrEMBL
	ZF_ZZ_2	UniProtKB/TrEMBL
SMART	APC10	UniProtKB/TrEMBL
	Cyt-b5	UniProtKB/TrEMBL
	HECTc	UniProtKB/TrEMBL
	TECPR	UniProtKB/TrEMBL
	ZnF_ZZ	UniProtKB/TrEMBL
Superfamily-SCOP	SSF159034	UniProtKB/TrEMBL
	SSF49785	UniProtKB/TrEMBL
	SSF50985	UniProtKB/TrEMBL
	SSF55856	UniProtKB/TrEMBL
	SSF56204	UniProtKB/TrEMBL
	Tudor/PWWP/MBT	UniProtKB/TrEMBL
UniProt	A0A2R9AKQ7	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9ALF0_PANPA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-03-13	LOC100976978	E3 ubiquitin-protein ligase HERC2	HERC2	HECT and RLD domain containing E3 ubiquitin protein ligase 2	Symbol and/or name change	5135510	APPROVED
2023-06-21	HERC2	HECT and RLD domain containing E3 ubiquitin protein ligase 2	LOC100976978	E3 ubiquitin-protein ligase HERC2	Symbol and/or name change	5135510	APPROVED
2020-07-01	LOC100976978	E3 ubiquitin-protein ligase HERC2	HERC2	HECT and RLD domain containing E3 ubiquitin protein ligase 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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