LOC100976978 (E3 ubiquitin-protein ligase HERC2) - Rat Genome Database

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Gene: LOC100976978 (E3 ubiquitin-protein ligase HERC2) Pan paniscus
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Symbol: LOC100976978 (Ensembl: HERC2)
Name: E3 ubiquitin-protein ligase HERC2 (Ensembl:HECT and RLD domain containing E3 ubiquitin protein ligase 2)
RGD ID: 11826136
Description: ENCODES a protein that exhibits metal ion binding (inferred); SUMO binding (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN negative regulation of Notch signaling pathway (ortholog); neuron differentiation (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH Angelman syndrome (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: HECT and RLD domain containing E3 ubiquitin protein ligase 2; HERC2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2166,961,516 - 7,171,075 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11510,603,053 - 10,812,747 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0151,590,558 - 1,800,023 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11525,535,760 - 25,746,444 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1525,536,483 - 25,746,074 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleus  (IEA)
plasma membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
LOC100976978
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2166,961,516 - 7,171,075 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11510,603,053 - 10,812,747 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0151,590,558 - 1,800,023 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11525,535,760 - 25,746,444 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1525,536,483 - 25,746,074 (-)Ensemblpanpan1.1panPan2
HERC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381528,111,040 - 28,322,179 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1528,111,040 - 28,322,179 (-)EnsemblGRCh38hg38GRCh38
GRCh371528,356,186 - 28,567,325 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361526,029,781 - 26,240,890 (-)NCBINCBI36Build 36hg18NCBI36
Build 341526,029,782 - 26,240,845NCBI
Celera156,513,422 - 6,701,708 (-)NCBICelera
Cytogenetic Map15q13.1NCBI
HuRef156,482,549 - 6,693,549 (-)NCBIHuRef
CHM1_11528,305,169 - 28,516,258 (-)NCBICHM1_1
T2T-CHM13v2.01525,853,561 - 26,064,943 (-)NCBIT2T-CHM13v2.0
Herc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39755,699,872 - 55,884,373 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl755,699,944 - 55,881,548 (+)EnsemblGRCm39 Ensembl
GRCm38756,050,124 - 56,231,800 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl756,050,196 - 56,231,800 (+)EnsemblGRCm38mm10GRCm38
MGSCv37763,305,525 - 63,487,170 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36755,918,272 - 56,099,815 (+)NCBIMGSCv36mm8
Celera753,391,067 - 53,570,966 (+)NCBICelera
Cytogenetic Map7B5NCBI
cM Map733.42NCBI
Herc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81116,009,681 - 116,243,888 (+)NCBIGRCr8
mRatBN7.21106,904,789 - 107,110,997 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1106,880,084 - 107,108,134 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1112,296,244 - 112,499,217 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01120,768,113 - 120,971,079 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01114,017,071 - 114,220,047 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01114,453,033 - 114,653,787 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1114,453,054 - 114,653,793 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01115,459,325 - 115,658,977 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41107,440,126 - 107,645,117 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11107,518,956 - 107,722,801 (+)NCBI
Celera1101,115,534 - 101,316,349 (+)NCBICelera
Cytogenetic Map1q22NCBI
Herc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555331,304,675 - 1,489,041 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555331,304,675 - 1,489,041 (+)NCBIChiLan1.0ChiLan1.0
HERC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1331,723,113 - 31,966,061 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl331,723,500 - 31,966,199 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha334,716,991 - 34,960,078 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0332,370,920 - 32,613,992 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1331,904,221 - 32,147,887 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0332,153,608 - 32,396,909 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0332,265,346 - 32,508,054 (+)NCBIUU_Cfam_GSD_1.0
Herc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640120,571,057 - 120,758,254 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647138,419,129 - 38,606,323 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647138,419,147 - 38,606,312 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HERC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1556,438,148 - 56,649,792 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11556,438,117 - 56,649,805 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21563,528,991 - 63,584,752 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HERC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12653,760,172 - 54,007,356 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2653,792,593 - 54,007,489 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605436,527,151 - 36,805,768 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000040672   ⟹   ENSPPAP00000017951
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1525,536,483 - 25,746,074 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000040679   ⟹   ENSPPAP00000017958
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1525,724,825 - 25,746,074 (-)Ensembl
RefSeq Acc Id: XM_034938387   ⟹   XP_034794278
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2166,961,516 - 7,171,075 (+)NCBI
NHGRI_mPanPan11510,603,059 - 10,812,747 (+)NCBI
Mhudiblu_PPA_v0151,590,562 - 1,800,023 (+)NCBI
RefSeq Acc Id: XM_034938388   ⟹   XP_034794279
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2166,961,516 - 7,171,075 (+)NCBI
NHGRI_mPanPan11510,603,059 - 10,812,747 (+)NCBI
Mhudiblu_PPA_v0151,590,564 - 1,800,023 (+)NCBI
RefSeq Acc Id: XM_034938393   ⟹   XP_034794284
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2166,961,516 - 7,171,075 (+)NCBI
NHGRI_mPanPan11510,603,053 - 10,812,747 (+)NCBI
Mhudiblu_PPA_v0151,590,558 - 1,800,023 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034794278 (Get FASTA)   NCBI Sequence Viewer  
  XP_034794279 (Get FASTA)   NCBI Sequence Viewer  
  XP_034794284 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000017951.1
  ENSPPAP00000017958.1
RefSeq Acc Id: XP_034794284   ⟸   XM_034938393
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AKQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034794278   ⟸   XM_034938387
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AKQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034794279   ⟸   XM_034938388
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AKQ7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000017951   ⟸   ENSPPAT00000040672
Ensembl Acc Id: ENSPPAP00000017958   ⟸   ENSPPAT00000040679
Protein Domains
Cytochrome b5 heme-binding   DOC   HECT   MIB/HERC2   ZZ-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031770 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000040672.1 UniProtKB/TrEMBL
  ENSPPAT00000040679.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.30 UniProtKB/TrEMBL
  2.30.30.30 UniProtKB/TrEMBL
  3.10.120.10 UniProtKB/TrEMBL
  3.30.60.90 UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro APC_su10/DOC_dom UniProtKB/TrEMBL
  Beta-propeller_rpt_TECPR UniProtKB/TrEMBL
  CPH_domain UniProtKB/TrEMBL
  Cyt_B5-like_heme/steroid-bd UniProtKB/TrEMBL
  Cyt_B5-like_heme/steroid_sf UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  HECT_dom UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  HERC2_APC10 UniProtKB/TrEMBL
  Mib_Herc2 UniProtKB/TrEMBL
  Mib_Herc2_sf UniProtKB/TrEMBL
  RCC1/BLIP-II UniProtKB/TrEMBL
  Reg_chr_condens UniProtKB/TrEMBL
  Rib_L2_dom2 UniProtKB/TrEMBL
  Ub_ligase/GEF_domain UniProtKB/TrEMBL
  Znf_ZZ UniProtKB/TrEMBL
  Znf_ZZ_sf UniProtKB/TrEMBL
  ZZ_HERC2 UniProtKB/TrEMBL
NCBI Gene HERC2 ENTREZGENE
PANTHER REGULATOR OF CHROMOSOME CONDENSATION UniProtKB/TrEMBL
  X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR-RELATED UniProtKB/TrEMBL
Pfam ANAPC10 UniProtKB/TrEMBL
  Cul7 UniProtKB/TrEMBL
  Cyt-b5 UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  MIB_HERC2 UniProtKB/TrEMBL
  PF00569 UniProtKB/TrEMBL
  RCC1 UniProtKB/TrEMBL
PRINTS RCCNDNSATION UniProtKB/TrEMBL
PROSITE CYTOCHROME_B5_2 UniProtKB/TrEMBL
  DOC UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  MIB_HERC2 UniProtKB/TrEMBL
  RCC1_2 UniProtKB/TrEMBL
  RCC1_3 UniProtKB/TrEMBL
  ZF_ZZ_1 UniProtKB/TrEMBL
  ZF_ZZ_2 UniProtKB/TrEMBL
SMART APC10 UniProtKB/TrEMBL
  Cyt-b5 UniProtKB/TrEMBL
  HECTc UniProtKB/TrEMBL
  TECPR UniProtKB/TrEMBL
  ZnF_ZZ UniProtKB/TrEMBL
Superfamily-SCOP SSF159034 UniProtKB/TrEMBL
  SSF49785 UniProtKB/TrEMBL
  SSF50985 UniProtKB/TrEMBL
  SSF55856 UniProtKB/TrEMBL
  SSF56204 UniProtKB/TrEMBL
  Tudor/PWWP/MBT UniProtKB/TrEMBL
UniProt A0A2R9AKQ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ALF0_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-03-13 LOC100976978  E3 ubiquitin-protein ligase HERC2  HERC2  HECT and RLD domain containing E3 ubiquitin protein ligase 2  Symbol and/or name change 5135510 APPROVED
2023-06-21 HERC2  HECT and RLD domain containing E3 ubiquitin protein ligase 2  LOC100976978  E3 ubiquitin-protein ligase HERC2  Symbol and/or name change 5135510 APPROVED
2020-07-01 LOC100976978  E3 ubiquitin-protein ligase HERC2  HERC2  HECT and RLD domain containing E3 ubiquitin protein ligase 2  Symbol and/or name change 5135510 APPROVED