PCK2 (phosphoenolpyruvate carboxykinase 2, mitochondrial) - Rat Genome Database

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Gene: PCK2 (phosphoenolpyruvate carboxykinase 2, mitochondrial) Pan paniscus
Analyze
Symbol: PCK2
Name: phosphoenolpyruvate carboxykinase 2, mitochondrial
RGD ID: 11807602
Description: ENCODES a protein that exhibits phosphoenolpyruvate carboxykinase (GTP) activity (ortholog); phosphoenolpyruvate carboxykinase activity (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); cellular response to tumor necrosis factor (ortholog); gluconeogenesis (ortholog); PARTICIPATES IN gluconeogenesis pathway; ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); COVID-19 (ortholog); Endotoxemia (ortholog); FOUND IN mitochondrial matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phosphoenolpyruvate carboxykinase [GTP], mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,450,239 - 25,460,233 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,666,731 - 24,676,725 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,872,276 - 4,882,118 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11422,996,813 - 23,006,775 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,996,813 - 23,006,775 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PCK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,450,239 - 25,460,233 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,666,731 - 24,676,725 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,872,276 - 4,882,118 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11422,996,813 - 23,006,775 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,996,813 - 23,006,775 (+)Ensemblpanpan1.1panPan2
PCK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,094,171 - 24,104,125 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,094,053 - 24,110,598 (+)EnsemblGRCh38hg38GRCh38
GRCh371424,563,520 - 24,573,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,633,323 - 23,643,179 (+)NCBINCBI36Build 36hg18NCBI36
Build 341423,633,388 - 23,643,173NCBI
Celera144,427,958 - 4,437,809 (+)NCBICelera
Cytogenetic Map14q11.2-q12NCBI
HuRef144,678,408 - 4,688,558 (+)NCBIHuRef
CHM1_11424,562,148 - 24,571,997 (+)NCBICHM1_1
T2T-CHM13v2.01418,292,333 - 18,302,437 (+)NCBIT2T-CHM13v2.0
Pck2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,777,721 - 55,787,477 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,777,723 - 55,788,699 (+)EnsemblGRCm39 Ensembl
GRCm381455,540,263 - 55,550,020 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,540,266 - 55,551,242 (+)EnsemblGRCm38mm10GRCm38
MGSCv371456,159,103 - 56,168,854 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,494,337 - 54,504,088 (+)NCBIMGSCv36mm8
Celera1453,345,110 - 53,354,861 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Pck2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,997,853 - 33,006,691 (+)NCBIGRCr8
mRatBN7.21529,027,891 - 29,036,729 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,027,894 - 29,037,283 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,873,592 - 30,882,430 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,020,798 - 32,029,636 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,263,142 - 30,271,980 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,216,735 - 34,224,357 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,216,833 - 34,224,193 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,106,930 - 38,114,552 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,671,834 - 33,680,613 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,677,328 - 33,696,192 (+)NCBI
Celera1528,603,811 - 28,612,649 (+)NCBICelera
Cytogenetic Map15p13NCBI
Pck2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540936,288,568 - 36,296,828 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540936,288,402 - 36,296,761 (-)NCBIChiLan1.0ChiLan1.0
PCK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,099,016 - 4,107,870 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,098,671 - 4,107,865 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,020,846 - 4,030,924 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,209,738 - 4,219,816 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,209,258 - 4,220,128 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,900,384 - 3,910,462 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,962,137 - 3,972,205 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,224,247 - 4,234,326 (+)NCBIUU_Cfam_GSD_1.0
Pck2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864035,951,769 - 35,960,519 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722428,307 - 437,328 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722428,473 - 450,452 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,187,197 - 75,197,733 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,187,195 - 75,197,613 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,458,494 - 80,468,914 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PCK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,077,206 - 1,087,306 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,077,447 - 1,087,607 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603612,759,325 - 12,769,341 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pck2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,426,606 - 8,436,284 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248208,426,456 - 8,436,484 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000044377   ⟹   ENSPPAP00000021574
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1422,996,813 - 23,006,775 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000044385   ⟹   ENSPPAP00000021582
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1423,000,983 - 23,006,611 (+)Ensembl
RefSeq Acc Id: XM_003809072   ⟹   XP_003809120
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21525,450,239 - 25,460,233 (+)NCBI
NHGRI_mPanPan11424,666,731 - 24,676,725 (+)NCBI
Mhudiblu_PPA_v0144,872,276 - 4,882,118 (+)NCBI
PanPan1.11422,996,813 - 23,006,775 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055097370   ⟹   XP_054953345
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21525,450,270 - 25,460,233 (+)NCBI
NHGRI_mPanPan11424,666,762 - 24,676,725 (+)NCBI
RefSeq Acc Id: XM_055097371   ⟹   XP_054953346
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21525,450,239 - 25,460,233 (+)NCBI
NHGRI_mPanPan11424,666,731 - 24,676,725 (+)NCBI
RefSeq Acc Id: XM_055097372   ⟹   XP_054953347
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21525,450,428 - 25,460,233 (+)NCBI
NHGRI_mPanPan11424,666,919 - 24,676,725 (+)NCBI
RefSeq Acc Id: XM_063596472   ⟹   XP_063452542
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21525,450,398 - 25,460,233 (+)NCBI
RefSeq Acc Id: XP_003809120   ⟸   XM_003809072
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AWJ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000021574   ⟸   ENSPPAT00000044377
Ensembl Acc Id: ENSPPAP00000021582   ⟸   ENSPPAT00000044385
RefSeq Acc Id: XP_054953346   ⟸   XM_055097371
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054953345   ⟸   XM_055097370
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054953347   ⟸   XM_055097372
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063452542   ⟸   XM_063596472
- Peptide Label: isoform X2

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000033979 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000044377.1 UniProtKB/TrEMBL
  ENSPPAT00000044385.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.449.10 UniProtKB/TrEMBL
  3.90.228.20 UniProtKB/TrEMBL
  Phosphoenolpyruvate Carboxykinase, domain 2 UniProtKB/TrEMBL
InterPro PEP_carboxykin_GTP_CS UniProtKB/TrEMBL
  PEP_carboxykinase_C UniProtKB/TrEMBL
  PEP_carboxykinase_GTP UniProtKB/TrEMBL
  PEP_carboxykinase_GTP_C UniProtKB/TrEMBL
  PEP_carboxykinase_GTP_N UniProtKB/TrEMBL
  PEP_carboxykinase_N UniProtKB/TrEMBL
KEGG Report pps:100973241 UniProtKB/TrEMBL
NCBI Gene PCK2 ENTREZGENE
PANTHER PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP], MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR11561 UniProtKB/TrEMBL
Pfam PEPCK_GTP UniProtKB/TrEMBL
  PEPCK_N UniProtKB/TrEMBL
PIRSF PEP_carboxykinase_GTP UniProtKB/TrEMBL
PROSITE PEPCK_GTP UniProtKB/TrEMBL
Superfamily-SCOP PEP carboxykinase-like UniProtKB/TrEMBL
  SSF68923 UniProtKB/TrEMBL
UniProt A0A2R9AWF3_PANPA UniProtKB/TrEMBL
  A0A2R9AWJ1 ENTREZGENE, UniProtKB/TrEMBL