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Gene: PSME2 (proteasome activator subunit 2) Pan paniscus

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Symbol:

PSME2

Name:

proteasome activator subunit 2

RGD ID:

11782446

Description:

ENCODES a protein that exhibits endopeptidase activator activity (ortholog); INVOLVED IN antigen processing and presentation of exogenous antigen (ortholog); ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); esophagus squamous cell carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); proteasome activator complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

proteasome (prosome, macropain) activator subunit 2 (PA28 beta); proteasome activator complex subunit 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	25,497,735 - 25,501,589 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	24,714,227 - 24,718,201 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	4,919,628 - 4,922,952 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	23,043,807 - 23,047,296 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	23,043,807 - 23,047,296 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PSME2	Bonobo	Brain-Lung-Thyroid Syndrome		ISO	PSME2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Brain-lung-thyroid syndrome	ClinVar	PMID:25741868
PSME2	Bonobo	lysinuric protein intolerance		ISO	PSME2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Lysinuric protein intolerance	ClinVar	PMID:28492532
PSME2	Bonobo	Specific Granule Deficiency		ISO	PSME2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Specific granule deficiency	ClinVar	PMID:28492532

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PSME2	Bonobo	esophagus squamous cell carcinoma		ISO	PSME2 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:21517111
PSME2	Bonobo	Experimental Liver Cirrhosis		ISO	PSME2 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:25380136
PSME2	Bonobo	human immunodeficiency virus infectious disease		ISO	PSME2 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:15308739

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PSME2	Bonobo	antigen processing and presentation of exogenous antigen	acts_upstream_of_or_within	ISO	MGI:2388601	9068941	PMID:15944286	MGI	PMID:15944286
PSME2	Bonobo	regulation of G1/S transition of mitotic cell cycle	involved_in	IEA	PANTHER:PTN001320178 more ...	150520179		TreeGrafter	GO_REF:0000118
PSME2	Bonobo	regulation of proteasomal protein catabolic process	involved_in	IEA	PANTHER:PTN001320178 more ...	150520179		TreeGrafter	GO_REF:0000118

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PSME2	Bonobo	cytoplasm	located_in	IEA	PANTHER:PTN001320178 more ...	150520179		TreeGrafter	GO_REF:0000118
PSME2	Bonobo	nucleoplasm	located_in	IEA	PANTHER:PTN001320178 more ...	150520179		TreeGrafter	GO_REF:0000118
PSME2	Bonobo	proteasome activator complex	part_of	IEA	InterPro:IPR003185 more ...	150520179		InterPro	GO_REF:0000002
PSME2	Bonobo	proteasome complex	part_of	IEA	UniProtKB-KW:KW-0647	150520179		UniProt	GO_REF:0000043

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PSME2	Bonobo	endopeptidase activator activity	enables	IEA	PANTHER:PTN001320178 more ...	150520179		TreeGrafter	GO_REF:0000118
PSME2	Bonobo	endopeptidase activator activity	contributes_to	ISO	Psme2 (Mus musculus)	9068941	PMID:15944286	MGI	PMID:15944286
PSME2	Bonobo	identical protein binding	enables	IEA	UniProtKB:Q9UL46 and ensembl:ENSP00000216802	150520179		Ensembl	GO_REF:0000107
PSME2	Bonobo	protein binding	enables	ISO	UniProtKB:Q06323	9068941	PMID:16189514 and PMID:35271311	IntAct	PMID:16189514 and PMID:35271311
PSME2	Bonobo	protein binding	enables	ISO	UniProtKB:O00560 and UniProtKB:Q06323	9068941	PMID:33961781	IntAct	PMID:33961781
PSME2	Bonobo	protein binding	enables	ISO	PR:P97371	9068941	PMID:15944286	MGI	PMID:15944286
PSME2	Bonobo	protein binding	enables	ISO	UniProtKB:O00560 more ...	9068941	PMID:32296183	IntAct	PMID:32296183

PMID:22301074	PMID:30032202

PSME2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	25,497,735 - 25,501,589 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	24,714,227 - 24,718,201 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	4,919,628 - 4,922,952 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	23,043,807 - 23,047,296 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	23,043,807 - 23,047,296 (-)	Ensembl	panpan1.1		panPan2

PSME2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	24,143,365 - 24,146,610 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	24,143,362 - 24,147,570 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	24,612,574 - 24,615,819 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	23,682,414 - 23,685,695 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	23,682,413 - 23,685,695	NCBI
Celera	14	4,477,042 - 4,480,323 (-)	NCBI		Celera
Cytogenetic Map	14	q12	NCBI
HuRef	14	4,727,638 - 4,730,919 (-)	NCBI		HuRef
CHM1_1	14	24,611,243 - 24,614,524 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	18,341,674 - 18,344,919 (-)	NCBI		T2T-CHM13v2.0

Psme2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	55,824,897 - 55,828,558 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	55,824,898 - 55,828,570 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	55,587,440 - 55,591,101 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	55,587,441 - 55,591,113 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	56,206,277 - 56,209,938 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	54,541,511 - 54,545,172 (-)	NCBI		MGSCv36	mm8
Celera	14	53,392,500 - 53,396,161 (-)	NCBI		Celera
Cytogenetic Map	14	C3	NCBI
cM Map	14	28.19	NCBI

Psme2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	33,048,452 - 33,053,055 (-)	NCBI		GRCr8
mRatBN7.2	15	29,078,495 - 29,082,794 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	29,078,500 - 29,082,946 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	30,924,197 - 30,928,500 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	32,071,403 - 32,075,706 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	30,313,749 - 30,318,048 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	34,265,552 - 34,269,851 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	34,265,557 - 34,269,851 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	38,155,747 - 38,160,046 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	33,722,370 - 33,726,669 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	33,738,074 - 33,742,369 (-)	NCBI
Celera	15	28,654,415 - 28,658,714 (-)	NCBI		Celera
Cytogenetic Map	15	p13	NCBI

Psme2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955409	36,252,847 - 36,257,021 (+)	NCBI	ChiLan1.0	ChiLan1.0

PSME2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	4,137,247 - 4,141,380 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	4,137,247 - 4,140,706 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	4,058,934 - 4,062,482 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	4,247,825 - 4,251,369 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	4,247,825 - 4,251,981 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	3,938,451 - 3,941,999 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	4,000,202 - 4,003,738 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	4,262,361 - 4,265,901 (-)	NCBI		UU_Cfam_GSD_1.0

Psme2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	35,987,005 - 35,991,113 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936722	397,876 - 402,167 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936722	398,406 - 401,987 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PSME2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	75,153,965 - 75,157,870 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	75,154,570 - 75,157,871 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	80,425,857 - 80,429,167 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	7	q12-q23	NCBI

PSME2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	1,129,389 - 1,133,289 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	1,129,419 - 1,132,596 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666036	12,811,110 - 12,814,585 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Psme2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624820	8,389,286 - 8,393,498 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624820	8,389,348 - 8,393,498 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_003809074	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000009286 ⟹ ENSPPAP00000001871

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	14	23,043,807 - 23,047,296 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000009328 ⟹ ENSPPAP00000001881

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	14	23,043,851 - 23,047,029 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000009331 ⟹ ENSPPAP00000001884

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	14	23,046,306 - 23,047,029 (-)	Ensembl

RefSeq Acc Id:

XM_003809074 ⟹ XP_003809122

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	15	25,497,735 - 25,501,589 (-)	NCBI
NHGRI_mPanPan1	14	24,714,227 - 24,718,201 (-)	NCBI
Mhudiblu_PPA_v0	14	4,919,628 - 4,922,952 (-)	NCBI
PanPan1.1	14	23,043,807 - 23,047,296 (-)	NCBI

Sequence:

show sequence

CCCCGCTCCAGTCTCCGCGGTCCCACTTACCCTAGCCCCTCCCTCGGGCAGCCCCTGGGCTGTGACCCAGCCAGCACCGCCTCTCCTAGTGGCAACTGGCTGGGAATGGCTGAGGGGCTACCTACTGC
TTGCGGCCTGCCAGGGGGAGGAGGGGGGGCGGAAAGAAGAAAGGGGGCGGGGTTGAGGGGGGCGGGCCTGGACCTGGGGAGTGAAAGCGAAAGCCCGGGCGACTAGCCGGGAGACCAGAGATCTAGCG
ACTGAAGCAGCATGGCCAAGCCGTGTGGGGTGCGCCTGAGCGGGGAAGCCCGCAAACAGGTGGAGGTCTTCAGGCAGAATCTTTTCCAGGAGGCTGAGGAATTCCTCTACAGATTCTTGCCACAGAAA
ATCATATACCTGAATCAGCTCTTGCAAGAGGACTCCCTCAATGTGGCTGACTTGACTTCCCTCCGGGCCCCACTGGACATCCCCATCCCAGACCCTCCACCCAAGGATGATGAGATGGAAACAGATAA
GCAGGAGAAGAAAGAAGTCCCTAAGTGTGGATTTCTCCCTGGGAATGAGAAAGTCCTGTCCCTGCTTGCCCTGGTTAAGCCAGAAGTCTGGACTCTCAAAGAGAAATGCATTCTGGTGATTACATGGA
TCCAACACCTGATCCCCAAGATTGAAGATGGAAATGATTTTGGGGTAGCAATCCAGGAGAAGGTGCTGGAGAGGGTGAATGCCGTCAAGACCAAAGTGGAAGCTTTCCAGACAACCATTTCCAAGTAC
TTCTCAGAACGTGGGGATGCTGTGGCCAAGGCCTCCAAGGAGACTCATGTAATGGATTACCGGGCCTTGGTGCATGAGCGAGATGAGGCAGCCTATGGGGAGCTCAGGGCCATGGTGCTGGACCTGAG
GGCCTTCTATGCTGAGCTTTATCATATCATCAGCAGCAACCTGGAGAAAATTGTCAACCCAAAGGGTGAAGAAAAGCCATCTATGTACTGAACCCAGGACTAGAAGGAAAATAAATGATCTATATGTT
GTGTGGA

hide sequence


Protein RefSeqs	XP_003809122	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000001149.1
	ENSPPAP00000001871.1
	ENSPPAP00000001881.1
	ENSPPAP00000001884.1

RefSeq Acc Id:

XP_003809122 ⟸ XM_003809074

- UniProtKB:

A0A2R8ZA22 (UniProtKB/TrEMBL), A0A2R8Z8I2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSLRAPLDIPIPDPPPKDDEMETDKQEKKEVPKCGFLPGNEKVLSLLALVKPEVWTLKEKCILVITWIQHL
IPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY

hide sequence

Ensembl Acc Id:

ENSPPAP00000001871 ⟸ ENSPPAT00000009286

Ensembl Acc Id:

ENSPPAP00000001881 ⟸ ENSPPAT00000009328

Ensembl Acc Id:

ENSPPAP00000001884 ⟸ ENSPPAT00000009331

Protein Domains

Proteasome activator PA28 C-terminal Proteasome activator PA28 N-terminal

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000004814	UniProtKB/TrEMBL
	ENSPPAG00000008454	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000005403.1	UniProtKB/TrEMBL
	ENSPPAT00000009286.1	UniProtKB/TrEMBL
	ENSPPAT00000009328.1	UniProtKB/TrEMBL
	ENSPPAT00000009331.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.120.180	UniProtKB/TrEMBL
	1.20.5.120	UniProtKB/TrEMBL
InterPro	PA28_C	UniProtKB/TrEMBL
	PA28_C_sf	UniProtKB/TrEMBL
	PA28_N_sf	UniProtKB/TrEMBL
	Proteasome_activ_PA28	UniProtKB/TrEMBL
	Proteasome_activ_PA28_N	UniProtKB/TrEMBL
	Proteasome_activ_sf	UniProtKB/TrEMBL
KEGG Report	pps:100973933	UniProtKB/TrEMBL
NCBI Gene	PSME2	ENTREZGENE
PANTHER	PROTEASOME ACTIVATOR COMPLEX SUBUNIT 2	UniProtKB/TrEMBL
	PTHR10660	UniProtKB/TrEMBL
Pfam	PA28_alpha	UniProtKB/TrEMBL
	PA28_beta	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47216	UniProtKB/TrEMBL
UniProt	A0A2R8Z8I2	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R8ZA22	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R8ZA30_PANPA	UniProtKB/TrEMBL
	A0A2R8ZGW1_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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