PSME2 (proteasome activator subunit 2) - Rat Genome Database

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Gene: PSME2 (proteasome activator subunit 2) Canis lupus familiaris
Analyze
Symbol: PSME2
Name: proteasome activator subunit 2
RGD ID: 12133442
Description: ENCODES a protein that exhibits endopeptidase activator activity (ortholog); INVOLVED IN antigen processing and presentation of exogenous antigen (ortholog); ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); esophagus squamous cell carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); proteasome activator complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: proteasome (prosome, macropain) activator subunit 2 (PA28 beta); proteasome activator complex subunit 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,137,247 - 4,141,380 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,137,247 - 4,140,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,058,934 - 4,062,482 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,247,825 - 4,251,369 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,247,825 - 4,251,981 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,938,451 - 3,941,999 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,000,202 - 4,003,738 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,262,361 - 4,265,901 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PSME2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,137,247 - 4,141,380 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,137,247 - 4,140,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,058,934 - 4,062,482 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,247,825 - 4,251,369 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,247,825 - 4,251,981 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,938,451 - 3,941,999 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,000,202 - 4,003,738 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,262,361 - 4,265,901 (-)NCBIUU_Cfam_GSD_1.0
PSME2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,143,365 - 24,146,610 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,143,362 - 24,147,570 (-)EnsemblGRCh38hg38GRCh38
GRCh371424,612,574 - 24,615,819 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,682,414 - 23,685,695 (-)NCBINCBI36Build 36hg18NCBI36
Build 341423,682,413 - 23,685,695NCBI
Celera144,477,042 - 4,480,323 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,727,638 - 4,730,919 (-)NCBIHuRef
CHM1_11424,611,243 - 24,614,524 (-)NCBICHM1_1
T2T-CHM13v2.01418,341,674 - 18,344,919 (-)NCBIT2T-CHM13v2.0
Psme2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,824,897 - 55,828,558 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,824,898 - 55,828,570 (-)EnsemblGRCm39 Ensembl
GRCm381455,587,440 - 55,591,101 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,587,441 - 55,591,113 (-)EnsemblGRCm38mm10GRCm38
MGSCv371456,206,277 - 56,209,938 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,541,511 - 54,545,172 (-)NCBIMGSCv36mm8
Celera1453,392,500 - 53,396,161 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Psme2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,048,452 - 33,053,055 (-)NCBIGRCr8
mRatBN7.21529,078,495 - 29,082,794 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,078,500 - 29,082,946 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1530,924,197 - 30,928,500 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,071,403 - 32,075,706 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,313,749 - 30,318,048 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,265,552 - 34,269,851 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,265,557 - 34,269,851 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,155,747 - 38,160,046 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,722,370 - 33,726,669 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,738,074 - 33,742,369 (-)NCBI
Celera1528,654,415 - 28,658,714 (-)NCBICelera
Cytogenetic Map15p13NCBI
Psme2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540936,252,847 - 36,257,021 (+)NCBIChiLan1.0ChiLan1.0
PSME2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,497,735 - 25,501,589 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,714,227 - 24,718,201 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,919,628 - 4,922,952 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,043,807 - 23,047,296 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,043,807 - 23,047,296 (-)Ensemblpanpan1.1panPan2
Psme2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864035,987,005 - 35,991,113 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722397,876 - 402,167 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722398,406 - 401,987 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSME2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,153,965 - 75,157,870 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,154,570 - 75,157,871 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,425,857 - 80,429,167 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q12-q23NCBI
PSME2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,129,389 - 1,133,289 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,129,419 - 1,132,596 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603612,811,110 - 12,814,585 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psme2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,389,286 - 8,393,498 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248208,389,348 - 8,393,498 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PSME2
36 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000019003   ⟹   ENSCAFP00000017612
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,137,251 - 4,140,706 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000077216   ⟹   ENSCAFP00000049584
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,137,247 - 4,140,686 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000082724   ⟹   ENSCAFP00000059140
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,137,251 - 4,140,706 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845008360   ⟹   ENSCAFP00845006579
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl84,247,825 - 4,251,257 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845008367   ⟹   ENSCAFP00845006583
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl84,247,830 - 4,251,981 (-)Ensembl
RefSeq Acc Id: XM_038482874   ⟹   XP_038338802
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.183,938,451 - 3,941,999 (-)NCBI
RefSeq Acc Id: XM_038544306   ⟹   XP_038400234
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.084,262,361 - 4,265,901 (-)NCBI
RefSeq Acc Id: XM_038608425   ⟹   XP_038464353
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.084,000,202 - 4,003,738 (-)NCBI
RefSeq Acc Id: XM_038673234   ⟹   XP_038529162
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.084,247,825 - 4,251,369 (-)NCBI
RefSeq Acc Id: XM_537382   ⟹   XP_537382
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.184,137,247 - 4,141,380 (-)NCBI
Dog10K_Boxer_Tasha84,058,934 - 4,062,482 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_537382   ⟸   XM_537382
- UniProtKB: A0A8C0PYS9 (UniProtKB/TrEMBL),   A0A8I3RTP1 (UniProtKB/TrEMBL),   A0A8C0QE81 (UniProtKB/TrEMBL),   A0A8I3MUE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000049584   ⟸   ENSCAFT00000077216
RefSeq Acc Id: ENSCAFP00000017612   ⟸   ENSCAFT00000019003
RefSeq Acc Id: ENSCAFP00000059140   ⟸   ENSCAFT00000082724
RefSeq Acc Id: XP_038338802   ⟸   XM_038482874
RefSeq Acc Id: XP_038464353   ⟸   XM_038608425
RefSeq Acc Id: XP_038529162   ⟸   XM_038673234
- UniProtKB: A0A8C0PYS9 (UniProtKB/TrEMBL),   A0A8I3RTP1 (UniProtKB/TrEMBL),   A0A8C0QE81 (UniProtKB/TrEMBL),   A0A8I3MUE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038400234   ⟸   XM_038544306
- UniProtKB: A0A8C0PYS9 (UniProtKB/TrEMBL),   A0A8C0QE81 (UniProtKB/TrEMBL),   A0A8I3MUE2 (UniProtKB/TrEMBL),   A0A8I3RTP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845006579   ⟸   ENSCAFT00845008360
RefSeq Acc Id: ENSCAFP00845006583   ⟸   ENSCAFT00845008367
Protein Domains
Proteasome activator PA28 C-terminal   Proteasome activator PA28 N-terminal

Promoters
RGD ID:13684150
Promoter ID:EPDNEW_C2218
Type:initiation region
Name:PSME2_1
Description:proteasome activator subunit 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.184,140,714 - 4,140,774EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011966 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030012056 UniProtKB/TrEMBL
  ENSCAFG00040003558 UniProtKB/TrEMBL
  ENSCAFG00845004671 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000019003.5 UniProtKB/TrEMBL
  ENSCAFT00000077216.2 UniProtKB/TrEMBL
  ENSCAFT00030022381.1 UniProtKB/TrEMBL
  ENSCAFT00030022448.1 UniProtKB/TrEMBL
  ENSCAFT00040006803.1 UniProtKB/TrEMBL
  ENSCAFT00040006840.1 UniProtKB/TrEMBL
  ENSCAFT00040006864.1 UniProtKB/TrEMBL
  ENSCAFT00845008360.1 UniProtKB/TrEMBL
  ENSCAFT00845008367 ENTREZGENE
  ENSCAFT00845008367.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.180 UniProtKB/TrEMBL
  1.20.5.120 UniProtKB/TrEMBL
InterPro PA28_C UniProtKB/TrEMBL
  PA28_C_sf UniProtKB/TrEMBL
  PA28_N_sf UniProtKB/TrEMBL
  Proteasome_activ_PA28 UniProtKB/TrEMBL
  Proteasome_activ_PA28_N UniProtKB/TrEMBL
  Proteasome_activ_sf UniProtKB/TrEMBL
KEGG Report cfa:480258 UniProtKB/TrEMBL
NCBI Gene PSME2 ENTREZGENE
PANTHER PROTEASOME ACTIVATOR COMPLEX SUBUNIT 2 UniProtKB/TrEMBL
  PTHR10660 UniProtKB/TrEMBL
Pfam PA28_alpha UniProtKB/TrEMBL
  PA28_beta UniProtKB/TrEMBL
Superfamily-SCOP SSF47216 UniProtKB/TrEMBL
UniProt A0A8C0PY46_CANLF UniProtKB/TrEMBL
  A0A8C0PYS9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QE81 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MUE2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RTP1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45117 ENTREZGENE