AUP1 (AUP1 lipid droplet regulating VLDL assembly factor) - Rat Genome Database

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Gene: AUP1 (AUP1 lipid droplet regulating VLDL assembly factor) Pan paniscus
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Symbol: AUP1
Name: AUP1 lipid droplet regulating VLDL assembly factor
RGD ID: 11775691
Description: ENCODES a protein that exhibits ubiquitin binding (inferred); ubiquitin conjugating enzyme binding (inferred); ubiquitin protein ligase binding (inferred); INVOLVED IN ERAD pathway (inferred); lipid droplet formation (inferred); lipid droplet organization (inferred); ASSOCIATED WITH congenital disorder of glycosylation type IIb (ortholog); dystonia (ortholog); Methylmalonyl-CoA Epimerase Deficiency (ortholog); FOUND IN autophagosome (inferred); endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ancient ubiquitous protein 1; AUP1, lipid droplet regulating VLDL assembly factor; lipid droplet-regulating VLDL assembly factor AUP1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21251,859,528 - 51,862,602 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A51,862,282 - 51,865,356 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A74,593,260 - 74,596,372 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A76,099,483 - 76,102,774 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,099,634 - 76,102,464 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AUP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21251,859,528 - 51,862,602 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A51,862,282 - 51,865,356 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A74,593,260 - 74,596,372 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A76,099,483 - 76,102,774 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,099,634 - 76,102,464 (-)Ensemblpanpan1.1panPan2
AUP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,526,652 - 74,529,706 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,526,645 - 74,529,760 (-)EnsemblGRCh38hg38GRCh38
GRCh37274,753,779 - 74,756,833 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,607,283 - 74,610,482 (-)NCBINCBI36Build 36hg18NCBI36
Celera274,584,883 - 74,588,082 (-)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef274,490,036 - 74,493,235 (-)NCBIHuRef
CHM1_1274,683,171 - 74,686,370 (-)NCBICHM1_1
T2T-CHM13v2.0274,535,217 - 74,538,272 (-)NCBIT2T-CHM13v2.0
Aup1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,031,483 - 83,034,663 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,031,502 - 83,034,789 (+)EnsemblGRCm39 Ensembl
GRCm38683,054,495 - 83,057,682 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,054,521 - 83,057,808 (+)EnsemblGRCm38mm10GRCm38
MGSCv37683,004,647 - 83,007,676 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36683,020,386 - 83,023,340 (+)NCBIMGSCv36mm8
Celera685,037,242 - 85,040,271 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Aup1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,118,035 - 117,121,063 (+)NCBIGRCr8
mRatBN7.24115,560,274 - 115,563,346 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,560,261 - 115,563,346 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,036,941 - 121,039,931 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,812,138 - 116,815,128 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,426,702 - 115,429,698 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04113,887,030 - 113,890,103 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,887,115 - 113,890,101 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04178,572,215 - 178,575,203 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,265,650 - 117,268,638 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4104,555,036 - 104,558,024 (+)NCBICelera
Cytogenetic Map4q34NCBI
Aup1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,259,432 - 11,262,269 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,259,288 - 11,262,413 (+)NCBIChiLan1.0ChiLan1.0
AUP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,613,648 - 48,617,091 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,613,725 - 48,616,728 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,255,441 - 48,258,987 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,472,997 - 49,476,542 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,473,160 - 49,476,542 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,490,146 - 48,493,692 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,556,890 - 48,560,436 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,114,568 - 49,118,113 (+)NCBIUU_Cfam_GSD_1.0
Aup1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244062929,995,869 - 9,998,950 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936556739,094 - 742,034 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936556738,946 - 742,049 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AUP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,519,969 - 68,523,073 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,520,048 - 68,523,076 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,690,861 - 71,850,888 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AUP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,748,737 - 32,751,924 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,748,909 - 32,751,776 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604579,419,360 - 79,422,463 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aup1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474928,983,802 - 28,986,643 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474928,983,753 - 28,986,785 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000035774   ⟹   ENSPPAP00000013106
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A76,099,634 - 76,102,464 (-)Ensembl
RefSeq Acc Id: XM_003810329   ⟹   XP_003810377
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21251,859,537 - 51,862,602 (+)NCBI
NHGRI_mPanPan12A51,862,291 - 51,865,356 (+)NCBI
Mhudiblu_PPA_v02A74,593,260 - 74,596,330 (-)NCBI
PanPan1.12A76,099,483 - 76,102,774 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008962677   ⟹   XP_008960925
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21251,859,528 - 51,862,602 (+)NCBI
NHGRI_mPanPan12A51,862,282 - 51,865,356 (+)NCBI
Mhudiblu_PPA_v02A74,593,260 - 74,596,372 (-)NCBI
PanPan1.12A76,099,483 - 76,102,726 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034953431   ⟹   XP_034809322
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21251,859,537 - 51,862,309 (+)NCBI
NHGRI_mPanPan12A51,862,291 - 51,864,946 (+)NCBI
Mhudiblu_PPA_v02A74,593,672 - 74,596,330 (-)NCBI
RefSeq Acc Id: XM_055107765   ⟹   XP_054963740
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21251,859,537 - 51,862,309 (+)NCBI
NHGRI_mPanPan12A51,862,291 - 51,865,025 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003810377 (Get FASTA)   NCBI Sequence Viewer  
  XP_008960925 (Get FASTA)   NCBI Sequence Viewer  
  XP_034809322 (Get FASTA)   NCBI Sequence Viewer  
  XP_054963740 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000013106
  ENSPPAP00000013106.1
RefSeq Acc Id: XP_003810377   ⟸   XM_003810329
- Peptide Label: isoform X1
- UniProtKB: A0A2R9ABX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008960925   ⟸   XM_008962677
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_034809322   ⟸   XM_034953431
- Peptide Label: isoform X3
- UniProtKB: A0A2R9ABX0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000013106   ⟸   ENSPPAT00000035774
RefSeq Acc Id: XP_054963740   ⟸   XM_055107765
- Peptide Label: isoform X4
Protein Domains
CUE


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029713 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000035774.1 UniProtKB/TrEMBL
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro AUP1_CUE UniProtKB/TrEMBL
  CUE UniProtKB/TrEMBL
NCBI Gene AUP1 ENTREZGENE
PANTHER ANCIENT UBIQUITOUS PROTEIN UniProtKB/TrEMBL
  LIPID DROPLET-REGULATING VLDL ASSEMBLY FACTOR AUP1 UniProtKB/TrEMBL
Pfam CUE UniProtKB/TrEMBL
PROSITE CUE UniProtKB/TrEMBL
SMART CUE UniProtKB/TrEMBL
UniProt A0A2R9ABX0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 AUP1  AUP1 lipid droplet regulating VLDL assembly factor    AUP1, lipid droplet regulating VLDL assembly factor  Symbol and/or name change 5135510 APPROVED
2017-10-10 AUP1  AUP1, lipid droplet regulating VLDL assembly factor    ancient ubiquitous protein 1  Symbol and/or name change 5135510 APPROVED