SAMSN1 (SAM domain, SH3 domain and nuclear localization signals 1) - Rat Genome Database

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Gene: SAMSN1 (SAM domain, SH3 domain and nuclear localization signals 1) Pan paniscus
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Symbol: SAMSN1
Name: SAM domain, SH3 domain and nuclear localization signals 1
RGD ID: 11765942
Description: ENCODES a protein that exhibits phosphotyrosine residue binding (inferred); INVOLVED IN negative regulation of peptidyl-tyrosine phosphorylation (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); COVID-19 (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100986888; putative uncharacterized protein ENSP00000383407; SAM domain-containing protein SAMSN-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22210,979,161 - 11,149,950 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1215,812,917 - 5,983,746 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0211,228,632 - 1,399,331 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12114,595,688 - 14,703,600 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2114,595,688 - 14,711,613 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SAMSN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22210,979,161 - 11,149,950 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1215,812,917 - 5,983,746 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0211,228,632 - 1,399,331 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12114,595,688 - 14,703,600 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2114,595,688 - 14,711,613 (-)Ensemblpanpan1.1panPan2
SAMSN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382114,485,228 - 14,659,417 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2114,485,228 - 14,658,821 (-)EnsemblGRCh38hg38GRCh38
GRCh372115,857,549 - 16,031,738 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362114,779,420 - 14,840,535 (-)NCBINCBI36Build 36hg18NCBI36
Build 342114,779,419 - 14,840,535NCBI
Celera211,027,395 - 1,088,492 (-)NCBICelera
Cytogenetic Map21q11.2NCBI
HuRef211,240,511 - 1,338,520 (-)NCBIHuRef
CHM1_12115,418,089 - 15,516,274 (-)NCBICHM1_1
T2T-CHM13v2.02112,840,563 - 13,014,732 (-)NCBIT2T-CHM13v2.0
Samsn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391675,655,682 - 75,706,154 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1675,655,681 - 75,819,169 (-)EnsemblGRCm39 Ensembl
GRCm381675,858,794 - 75,909,266 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1675,858,793 - 76,022,281 (-)EnsemblGRCm38mm10GRCm38
MGSCv371675,859,039 - 75,909,511 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361675,741,474 - 75,791,946 (-)NCBIMGSCv36mm8
Celera1676,082,014 - 76,131,797 (-)NCBICelera
Cytogenetic Map16C3.1NCBI
cM Map1643.36NCBI
Samsn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81127,971,565 - 28,021,944 (-)NCBIGRCr8
mRatBN7.21114,484,523 - 14,534,900 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1114,483,893 - 14,534,900 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1123,110,271 - 23,160,500 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01115,836,651 - 15,886,876 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01115,004,507 - 15,054,732 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01114,252,088 - 14,405,825 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1114,253,848 - 14,304,725 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01117,910,040 - 17,960,596 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41114,633,494 - 14,683,788 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11114,633,493 - 14,683,788 (-)NCBI
Celera1114,497,563 - 14,547,805 (-)NCBICelera
Cytogenetic Map11p11NCBI
Samsn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540716,329,288 - 16,378,062 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540716,329,838 - 16,377,763 (-)NCBIChiLan1.0ChiLan1.0
SAMSN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13111,485,964 - 11,756,275 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3111,486,649 - 11,754,607 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3111,497,136 - 11,766,896 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03111,510,963 - 11,781,247 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3111,510,981 - 11,781,296 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13111,484,017 - 11,753,288 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03111,521,549 - 11,791,326 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03111,917,912 - 12,187,664 (-)NCBIUU_Cfam_GSD_1.0
Samsn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497112,580,579 - 12,671,795 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365057,499,719 - 7,550,679 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365057,499,801 - 7,591,566 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SAMSN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13179,428,779 - 179,556,447 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113179,431,494 - 179,509,359 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213189,668,581 - 189,798,767 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103218266
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1277,870,604 - 78,038,215 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl277,937,984 - 78,038,199 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605075,882,004 - 76,050,679 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Samsn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247452,977,395 - 3,022,694 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247452,977,401 - 3,022,606 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000050575   ⟹   ENSPPAP00000027732
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2114,595,688 - 14,711,613 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000050580   ⟹   ENSPPAP00000027737
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2114,595,688 - 14,657,077 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000050585   ⟹   ENSPPAP00000027742
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2114,596,372 - 14,656,701 (-)Ensembl
RefSeq Acc Id: XM_003819190   ⟹   XP_003819238
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22210,979,161 - 11,040,303 (-)NCBI
NHGRI_mPanPan1215,812,917 - 5,874,046 (-)NCBI
Mhudiblu_PPA_v0211,228,632 - 1,289,780 (-)NCBI
PanPan1.12114,595,688 - 14,656,800 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024927031   ⟹   XP_024782799
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22210,979,161 - 11,149,950 (-)NCBI
NHGRI_mPanPan1215,812,917 - 5,983,746 (-)NCBI
Mhudiblu_PPA_v0211,228,632 - 1,399,331 (-)NCBI
PanPan1.12114,595,688 - 14,703,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055105188   ⟹   XP_054961163
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22210,979,161 - 11,109,082 (-)NCBI
NHGRI_mPanPan1215,812,917 - 5,942,839 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003819238 (Get FASTA)   NCBI Sequence Viewer  
  XP_024782799 (Get FASTA)   NCBI Sequence Viewer  
  XP_054961163 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000027732.1
  ENSPPAP00000027737.1
  ENSPPAP00000027742.1
RefSeq Acc Id: XP_003819238   ⟸   XM_003819190
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BEX3 (UniProtKB/TrEMBL),   A0A2R9BEW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024782799   ⟸   XM_024927031
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSPPAP00000027732   ⟸   ENSPPAT00000050575
Ensembl Acc Id: ENSPPAP00000027737   ⟸   ENSPPAT00000050580
Ensembl Acc Id: ENSPPAP00000027742   ⟸   ENSPPAT00000050585
RefSeq Acc Id: XP_054961163   ⟸   XM_055105188
- Peptide Label: isoform X2
Protein Domains
SAM   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036931 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000050575.1 UniProtKB/TrEMBL
  ENSPPAT00000050580.1 UniProtKB/TrEMBL
  ENSPPAT00000050585.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro rSAM/SH3_domain-containing UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM-SH3_domain_protein UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  SAMSN1_SAM UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report pps:100986338 UniProtKB/TrEMBL
NCBI Gene SAMSN1 ENTREZGENE
PANTHER SAM DOMAIN-CONTAINING PROTEIN SAMSN-1 UniProtKB/TrEMBL
  SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED UniProtKB/TrEMBL
Pfam SAM_2 UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
  SLY UniProtKB/TrEMBL
PROSITE SAM_DOMAIN UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SAM UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A2R9BEW5 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BEX3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BEY0_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-11 SAMSN1  SAM domain, SH3 domain and nuclear localization signals 1  LOC100986888  putative uncharacterized protein ENSP00000383407  Data merged from RGD:11793750 737654 PROVISIONAL