TMPRSS3 (transmembrane serine protease 3) - Rat Genome Database

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Gene: TMPRSS3 (transmembrane serine protease 3) Pan paniscus
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Symbol: TMPRSS3
Name: transmembrane serine protease 3
RGD ID: 11756995
Description: ENCODES a protein that exhibits serine-type endopeptidase activity (inferred); serine-type peptidase activity (inferred); sodium channel regulator activity (inferred); INVOLVED IN intracellular sodium ion homeostasis (ortholog); ASSOCIATED WITH autosomal recessive nonsyndromic deafness (ortholog); autosomal recessive nonsyndromic deafness 8 (ortholog); cataract 9 multiple types (ortholog); FOUND IN endomembrane system (inferred); endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transmembrane protease serine 3; transmembrane protease, serine 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22238,424,833 - 38,451,937 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12133,280,075 - 33,304,405 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02128,679,488 - 28,703,313 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12141,997,642 - 42,022,740 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2141,997,642 - 42,022,740 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
TMPRSS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22238,424,833 - 38,451,937 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12133,280,075 - 33,304,405 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02128,679,488 - 28,703,313 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12141,997,642 - 42,022,740 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2141,997,642 - 42,022,740 (-)Ensemblpanpan1.1panPan2
TMPRSS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382142,371,890 - 42,396,052 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2142,371,887 - 42,396,091 (-)EnsemblGRCh38hg38GRCh38
GRCh372143,791,999 - 43,816,161 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362142,665,068 - 42,689,269 (-)NCBINCBI36Build 36hg18NCBI36
Build 342142,675,054 - 42,689,269NCBI
Celera2128,940,972 - 28,965,175 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2129,209,266 - 29,234,349 (-)NCBIHuRef
CHM1_12143,352,168 - 43,377,125 (-)NCBICHM1_1
T2T-CHM13v2.02140,761,358 - 40,785,622 (-)NCBIT2T-CHM13v2.0
Tmprss3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391731,398,237 - 31,419,478 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1731,398,239 - 31,417,951 (-)EnsemblGRCm39 Ensembl
GRCm381731,179,263 - 31,200,504 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1731,179,265 - 31,198,977 (-)EnsemblGRCm38mm10GRCm38
MGSCv371731,316,210 - 31,335,919 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361730,906,277 - 30,924,761 (-)NCBIMGSCv36mm8
Celera1732,096,501 - 32,116,151 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.8NCBI
Tmprss3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8209,253,497 - 9,275,167 (-)NCBIGRCr8
mRatBN7.2209,254,102 - 9,273,808 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,254,109 - 9,274,363 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx209,948,938 - 9,968,144 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0209,310,108 - 9,329,314 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0209,785,246 - 9,804,454 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0209,910,522 - 9,929,705 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl209,910,522 - 9,929,705 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02012,090,226 - 12,109,848 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4209,545,077 - 9,564,261 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1209,546,507 - 9,565,698 (-)NCBI
Celera2010,778,412 - 10,797,597 (-)NCBICelera
Cytogenetic Map20p12NCBI
Tmprss3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540739,332,052 - 39,354,488 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540739,332,517 - 39,351,699 (+)NCBIChiLan1.0ChiLan1.0
TMPRSS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13136,706,229 - 36,730,444 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3136,707,723 - 36,730,520 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3135,857,157 - 35,881,007 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03136,222,870 - 36,246,768 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3136,224,343 - 36,245,196 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13136,115,692 - 36,139,512 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03136,095,952 - 36,119,868 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03136,591,047 - 36,614,888 (-)NCBIUU_Cfam_GSD_1.0
Tmprss3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497135,965,571 - 35,987,749 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365001,480,688 - 1,501,735 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365001,480,688 - 1,501,735 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMPRSS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13205,709,663 - 205,732,824 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113205,707,501 - 205,733,037 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213216,114,614 - 216,137,024 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMPRSS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1286,248,792 - 86,273,715 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl286,245,507 - 86,272,196 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605414,209,710 - 14,233,132 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmprss3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474528,064,539 - 28,083,566 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474528,064,414 - 28,087,319 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000037224   ⟹   ENSPPAP00000014538
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2141,997,642 - 42,022,740 (-)Ensembl
RefSeq Acc Id: XM_034947989   ⟹   XP_034803880
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22238,424,833 - 38,451,937 (-)NCBI
NHGRI_mPanPan12133,280,075 - 33,304,405 (-)NCBI
Mhudiblu_PPA_v02128,679,488 - 28,703,290 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034803880 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000014538.1
RefSeq Acc Id: XP_034803880   ⟸   XM_034947989
- UniProtKB: A0A2R9AG78 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000014538   ⟸   ENSPPAT00000037224
Protein Domains
Peptidase S1   SRCR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030425 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000037224.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  3.10.250.10 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
InterPro LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  SRCR UniProtKB/TrEMBL
  SRCR-like_dom UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
NCBI Gene TMPRSS3 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEASE SERINE 3-LIKE UniProtKB/TrEMBL
Pfam Ldl_recept_a UniProtKB/TrEMBL
  SRCR_2 UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  SRCR_1 UniProtKB/TrEMBL
  SRCR_2 UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART LDLa UniProtKB/TrEMBL
  SM00202 UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
  SSF56487 UniProtKB/TrEMBL
  SSF57424 UniProtKB/TrEMBL
UniProt A0A2R9AG78 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-23 TMPRSS3  transmembrane serine protease 3    transmembrane protease, serine 3  Symbol and/or name change 5135510 APPROVED