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Gene: TMPRSS3 (transmembrane serine protease 3) Homo sapiens
Symbol: TMPRSS3
Name: transmembrane serine protease 3
Description: Exhibits sodium channel regulator activity. Involved in cellular sodium ion homeostasis. Localizes to endoplasmic reticulum membrane. Implicated in autosomal recessive nonsyndromic deafness 8 and sensorineural hearing loss. Biomarker of pancreatic ductal carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DFNB10; DFNB8; ECHOS1; serine protease TADG-12; serine protease TADG12; TADG12; transmembrane protease serine 3; transmembrane protease, serine 3; tumor-associated differentially-expressed gene 12 protein
Mus musculus (house mouse) : Tmprss3 (transmembrane protease, serine 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tmprss3 (transmembrane serine protease 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tmprss3 (transmembrane serine protease 3)
Pan paniscus (bonobo/pygmy chimpanzee) : TMPRSS3 (transmembrane serine protease 3)
Canis lupus familiaris (dog) : TMPRSS3 (transmembrane serine protease 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tmprss3 (transmembrane serine protease 3)
Sus scrofa (pig) : TMPRSS3 (transmembrane serine protease 3)
Chlorocebus sabaeus (African green monkey) : TMPRSS3 (transmembrane serine protease 3)
Heterocephalus glaber (naked mole-rat) : Tmprss3 (transmembrane serine protease 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2142,371,837 - 42,396,091 (-)EnsemblGRCh38hg38GRCh38
GRCh382142,371,837 - 42,396,052 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372143,791,996 - 43,816,955 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362142,665,068 - 42,689,269 (-)NCBINCBI36hg18NCBI36
Build 342142,675,054 - 42,689,269NCBI
Celera2128,940,972 - 28,965,175 (-)NCBI
Cytogenetic Map21q22.3NCBI
HuRef2129,209,266 - 29,234,349 (-)NCBIHuRef
CHM1_12143,352,168 - 43,377,125 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TMPRSS3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320861
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.