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Gene: PIGL (phosphatidylinositol glycan anchor biosynthesis class L) Pan paniscus

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Symbol:

PIGL

Name:

phosphatidylinositol glycan anchor biosynthesis class L

RGD ID:

11753271

Description:

ENCODES a protein that exhibits hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (inferred); N-acetylglucosaminylphosphatidylinositol deacetylase activity (inferred); INVOLVED IN GPI anchor biosynthetic process (ortholog); ASSOCIATED WITH CHIME syndrome (ortholog); genetic disease (ortholog); hyperphosphatasia with impaired intellectual development syndrome (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	56,283,682 - 56,417,860 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	61,097,246 - 61,229,497 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	35,122,347 - 35,252,800 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	110,417,772 - 110,523,985 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	110,417,770 - 110,546,387 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PIGL	Bonobo	CHIME syndrome		ISO	RGD:1342664	8554872	ClinVar Annotator: match by term: CHIME syndrome \| ClinVar Annotator: match by term: Coloboma, Congenital more ...	ClinVar	PMID:11438011\|PMID:16199547\|PMID:18414213\|PMID:22444671\|PMID:23561846\|PMID:24784135\|PMID:25250048\|PMID:25741868\|PMID:28327575\|PMID:28371479\|PMID:28492532\|PMID:29473937\|PMID:30023290\|PMID:3041916\|PMID:31535386\|PMID:35904974\|PMID:7666399\|PMID:8893234
PIGL	Bonobo	genetic disease		ISO	RGD:1342664	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:18414213\|PMID:22444671\|PMID:23561846\|PMID:24784135\|PMID:25250048\|PMID:25741868\|PMID:28371479\|PMID:28492532\|PMID:29473937\|PMID:3041916\|PMID:31535386\|PMID:35904974\|PMID:7666399\|PMID:8893234
PIGL	Bonobo	hyperphosphatasia with impaired intellectual development syndrome		ISO	RGD:1342664	8554872	ClinVar Annotator: match by term: MABRY SYNDROME	ClinVar
PIGL	Bonobo	hyperphosphatasia with impaired intellectual development syndrome 1		ISO	RGD:1342664	8554872	ClinVar Annotator: match by term: GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 2	ClinVar
PIGL	Bonobo	Hypertelorism		ISO	RGD:1342664	8554872	ClinVar Annotator: match by term: Hypertelorism	ClinVar	PMID:18414213\|PMID:22444671\|PMID:23561846\|PMID:24784135\|PMID:25250048\|PMID:25741868\|PMID:28371479\|PMID:28492532\|PMID:29473937\|PMID:3041916\|PMID:31535386\|PMID:35904974\|PMID:7666399\|PMID:8893234
PIGL	Bonobo	Premature Birth		ISO	RGD:1342664	8554872	ClinVar Annotator: match by term: Premature birth	ClinVar	PMID:18414213\|PMID:22444671\|PMID:23561846\|PMID:24784135\|PMID:25250048\|PMID:25741868\|PMID:28371479\|PMID:28492532\|PMID:29473937\|PMID:3041916\|PMID:31535386\|PMID:35904974\|PMID:7666399\|PMID:8893234

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PIGL	Bonobo	CHIME syndrome		ISO	RGD:1342664	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PIGL	Bonobo	GPI anchor biosynthetic process		ISO	RGD:620437	9068941		RGD	PMID:9188481\|REF_RGD_ID:729509
PIGL	Bonobo	GPI anchor biosynthetic process	involved_in	IEA	UniPathway:UPA00196	150520179		UniProt	GO_REF:0000041
PIGL	Bonobo	GPI anchor biosynthetic process	involved_in	IEA	UniProtKB:Q9Y2B2\|ensembl:ENSP00000225609	150520179		Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PIGL	Bonobo	endoplasmic reticulum	located_in	IEA	PANTHER:PTN000313019\|PANTHER:PTN002659438	150520179		TreeGrafter	GO_REF:0000118
PIGL	Bonobo	endoplasmic reticulum membrane	located_in	IEA	UniProtKB:Q9Y2B2\|ensembl:ENSP00000225609	150520179		Ensembl	GO_REF:0000107
PIGL	Bonobo	membrane	located_in	IEA	GO:0006506	150520179		GOC	GO_REF:0000108

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PIGL	Bonobo	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	enables	IEA	PANTHER:PTN000313019\|PANTHER:PTN002659438	150520179		TreeGrafter	GO_REF:0000118
PIGL	Bonobo	N-acetylglucosaminylphosphatidylinositol deacetylase activity	enables	IEA	EC:3.5.1.89	150520179		UniProt	GO_REF:0000003
PIGL	Bonobo	N-acetylglucosaminylphosphatidylinositol deacetylase activity	enables	IEA	PANTHER:PTN000313019\|PANTHER:PTN002659438	150520179		TreeGrafter	GO_REF:0000118

PMID:30032202

PIGL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	56,283,682 - 56,417,860 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	61,097,246 - 61,229,497 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	35,122,347 - 35,252,800 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	110,417,772 - 110,523,985 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	110,417,770 - 110,546,387 (+)	Ensembl	panpan1.1		panPan2

PIGL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	16,217,210 - 16,326,411 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	16,217,191 - 16,351,797 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	16,120,524 - 16,229,725 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	16,061,234 - 16,170,298 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	16,061,260 - 16,170,296	NCBI
Celera	17	16,023,433 - 16,132,500 (+)	NCBI		Celera
Cytogenetic Map	17	p11.2	NCBI
HuRef	17	15,987,546 - 16,096,166 (+)	NCBI		HuRef
CHM1_1	17	16,130,315 - 16,239,332 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	16,119,521 - 16,254,125 (+)	NCBI		T2T-CHM13v2.0

Pigl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	62,349,267 - 62,406,863 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	62,349,286 - 62,405,243 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	62,458,441 - 62,516,037 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	62,458,460 - 62,514,417 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	62,271,962 - 62,327,402 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	62,274,655 - 62,330,095 (+)	NCBI		MGSCv36	mm8
Celera	11	69,377,657 - 69,433,527 (+)	NCBI		Celera
Cytogenetic Map	11	B2	NCBI
cM Map	11	38.34	NCBI

Pigl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	47,641,478 - 47,699,200 (+)	NCBI		GRCr8
mRatBN7.2	10	47,142,160 - 47,199,892 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	47,141,780 - 47,200,145 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	51,845,763 - 51,903,705 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	51,336,320 - 51,394,255 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	46,839,726 - 46,897,666 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	48,774,018 - 48,831,848 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	48,773,828 - 48,831,855 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	48,560,437 - 48,618,267 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	48,629,666 - 48,689,128 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	48,642,908 - 48,703,004 (+)	NCBI
Celera	10	46,389,721 - 46,447,273 (+)	NCBI		Celera
Cytogenetic Map	10	q23	NCBI

Pigl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955467	1,566,494 - 1,645,158 (+)	NCBI	ChiLan1.0	ChiLan1.0

PIGL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	39,601,288 - 39,687,125 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	39,601,291 - 39,686,908 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	39,747,720 - 39,833,502 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	39,711,630 - 39,797,577 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	39,711,924 - 39,797,068 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	39,683,300 - 39,769,219 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	39,628,568 - 39,714,511 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	39,820,769 - 39,906,365 (-)	NCBI		UU_Cfam_GSD_1.0

Pigl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	59,431,040 - 59,523,768 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936821	288,026 - 381,172 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936821	290,240 - 381,126 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PIGL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	59,201,556 - 59,256,829 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	59,217,267 - 59,256,896 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	62,342,368 - 62,382,439 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PIGL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	15,340,548 - 15,351,677 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666059	5,518,598 - 5,629,387 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pigl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624877	4,117,075 - 4,202,616 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624877	4,078,752 - 4,202,024 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_003831159	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055101254	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055101255	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010110672	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010110673	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010110674	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010110675	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010110676	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010110677	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000062300 ⟹ ENSPPAP00000039389

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	2A	110,417,770 - 110,523,985 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000062303 ⟹ ENSPPAP00000039392

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	2A	110,418,208 - 110,546,387 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000062308 ⟹ ENSPPAP00000039397

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	2A	110,418,208 - 110,523,632 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000062312 ⟹ ENSPPAP00000039401

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	2A	110,418,208 - 110,478,875 (+)	Ensembl

RefSeq Acc Id:

XM_055101254 ⟹ XP_054957229

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	56,299,451 - 56,417,860 (-)	NCBI
NHGRI_mPanPan1	17	61,104,476 - 61,229,497 (-)	NCBI

RefSeq Acc Id:

XM_055101255 ⟹ XP_054957230

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	56,299,451 - 56,417,860 (-)	NCBI
NHGRI_mPanPan1	17	61,104,476 - 61,229,497 (-)	NCBI

RefSeq Acc Id:

XR_010110672

Type:

NON-CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	56,283,682 - 56,417,860 (-)	NCBI

RefSeq Acc Id:

XR_010110673

Type:

NON-CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	56,283,682 - 56,417,860 (-)	NCBI

RefSeq Acc Id:

XR_010110674

Type:

NON-CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	56,283,682 - 56,417,860 (-)	NCBI

RefSeq Acc Id:

XR_010110675

Type:

NON-CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	56,283,682 - 56,417,860 (-)	NCBI

RefSeq Acc Id:

XR_010110676

Type:

NON-CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	56,292,772 - 56,417,860 (-)	NCBI

RefSeq Acc Id:

XR_010110677

Type:

NON-CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	56,318,614 - 56,417,860 (-)	NCBI


Protein RefSeqs	XP_054957229	(Get FASTA)	NCBI Sequence Viewer
	XP_054957230	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000039389.1
	ENSPPAP00000039392.1
	ENSPPAP00000039397.1
	ENSPPAP00000039401.1

Ensembl Acc Id:

ENSPPAP00000039397 ⟸ ENSPPAT00000062308

Ensembl Acc Id:

ENSPPAP00000039401 ⟸ ENSPPAT00000062312

Ensembl Acc Id:

ENSPPAP00000039392 ⟸ ENSPPAT00000062303

Ensembl Acc Id:

ENSPPAP00000039389 ⟸ ENSPPAT00000062300

RefSeq Acc Id:	XP_054957230 ⟸ XM_055101255
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9CBY2 (UniProtKB/TrEMBL)

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000042398	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000062300.1	UniProtKB/TrEMBL
	ENSPPAT00000062303.1	UniProtKB/TrEMBL
	ENSPPAT00000062308.1	UniProtKB/TrEMBL
	ENSPPAT00000062312.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.10320	UniProtKB/TrEMBL
InterPro	GlcNAc_PI_deacetylase-related	UniProtKB/TrEMBL
	LmbE-like_dom_sf	UniProtKB/TrEMBL
NCBI Gene	PIGL	ENTREZGENE
PANTHER	PTHR12993	UniProtKB/TrEMBL
	PTHR12993:SF11	UniProtKB/TrEMBL
Pfam	PIG-L	UniProtKB/TrEMBL
Superfamily-SCOP	SSF102588	UniProtKB/TrEMBL
UniProt	A0A2R9CBU3_PANPA	UniProtKB/TrEMBL
	A0A2R9CBY2	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9CMQ1_PANPA	UniProtKB/TrEMBL
	A0A2R9CMQ7_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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