FSCN2 (fascin actin-bundling protein 2, retinal)

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Gene: FSCN2 (fascin actin-bundling protein 2, retinal) Pan paniscus

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Symbol:

FSCN2

Name:

fascin actin-bundling protein 2, retinal

RGD ID:

11744023

Description:

ENCODES a protein that exhibits actin binding (inferred); actin filament binding (inferred); protein-macromolecule adaptor activity (inferred); INVOLVED IN eye photoreceptor cell development (ortholog); ASSOCIATED WITH auditory system disease (ortholog); fundus dystrophy (ortholog); Leber congenital amaurosis (ortholog); FOUND IN actin cytoskeleton (inferred); cytoplasm (inferred); cytoskeleton (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

fascin homolog 2, actin-bundling protein, retinal; fascin-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	98,111,412 - 98,126,571 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	103,013,967 - 103,024,231 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	75,974,971 - 75,993,275 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	81,687,051 - 81,694,823 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	81,687,051 - 81,694,823 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

auditory system disease (ISO)

fundus dystrophy (ISO)

Leber congenital amaurosis (ISO)

macular degeneration (ISO)

Meniere's disease (ISO)

retinal degeneration (ISO)

retinitis pigmentosa (ISO)

retinitis pigmentosa 30 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament bundle assembly (IEA)

actin filament organization (IEA)

cell migration (IEA)

establishment or maintenance of cell polarity (IEA)

eye photoreceptor cell development (IEA,ISO)

Cellular Component

actin cytoskeleton (IEA)

cytoplasm (IEA)

cytoskeleton (IEA)

stereocilium (IEA)

Molecular Function

actin binding (IEA)

actin filament binding (IEA)

protein binding (ISO)

protein-macromolecule adaptor activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

FSCN2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	98,111,412 - 98,126,571 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	103,013,967 - 103,024,231 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	75,974,971 - 75,993,275 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	81,687,051 - 81,694,823 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	81,687,051 - 81,694,823 (+)	Ensembl	panpan1.1		panPan2

FSCN2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	81,515,062 - 81,537,130 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	81,528,377 - 81,537,130 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	79,495,403 - 79,504,156 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	77,110,012 - 77,114,632 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	77,110,016 - 77,114,631	NCBI
Celera	17	76,139,079 - 76,148,244 (+)	NCBI		Celera
Cytogenetic Map	17	q25.3	NCBI
HuRef	17	74,944,167 - 74,951,874 (+)	NCBI		HuRef
CHM1_1	17	79,581,654 - 79,590,360 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	82,430,273 - 82,454,442 (+)	NCBI		T2T-CHM13v2.0

Fscn2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	120,250,991 - 120,258,999 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	120,252,360 - 120,258,994 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	120,360,165 - 120,368,173 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	120,361,534 - 120,368,168 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	120,222,848 - 120,229,487 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	120,177,624 - 120,184,261 (+)	NCBI		MGSCv36	mm8
Celera	11	132,096,284 - 132,102,924 (+)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI
cM Map	11	84.08	NCBI

Fscn2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	106,121,038 - 106,139,683 (+)	NCBI		GRCr8
mRatBN7.2	10	105,634,783 - 105,641,322 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	105,634,783 - 105,641,322 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	110,739,192 - 110,745,719 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	110,202,211 - 110,208,738 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	105,555,265 - 105,561,804 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	109,528,307 - 109,540,675 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	109,533,487 - 109,540,026 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	109,128,055 - 109,134,594 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	109,789,092 - 109,795,631 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	109,803,763 - 109,810,072 (+)	NCBI
Celera	10	104,180,130 - 104,186,669 (+)	NCBI		Celera
Cytogenetic Map	10	q32.3	NCBI

Fscn2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955506	1,526,830 - 1,533,775 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955506	1,526,830 - 1,533,775 (-)	NCBI	ChiLan1.0	ChiLan1.0

FSCN2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	616,088 - 622,152 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	617,609 - 621,882 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	1,218,766 - 1,224,987 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	1,210,196 - 1,216,414 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	1,211,869 - 1,216,141 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	1,234,897 - 1,241,112 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	1,360,741 - 1,366,958 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	1,440,630 - 1,446,849 (-)	NCBI		UU_Cfam_GSD_1.0

Fscn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	1,216,619 - 1,227,828 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	5,184,628 - 5,191,985 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936594	5,184,133 - 5,195,340 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FSCN2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	1,300,055 - 1,309,778 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	1,300,286 - 1,311,562 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	1,143,345 - 1,156,961 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FSCN2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	73,472,582 - 73,482,440 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	73,474,519 - 73,481,967 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	44,854,818 - 44,864,455 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fscn2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	10,511,673 - 10,517,753 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624801	10,511,539 - 10,518,073 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003831122	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055101983	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000060935 ⟹ ENSPPAP00000038032

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	17	81,687,051 - 81,694,823 (+)	Ensembl

RefSeq Acc Id:

XM_003831122 ⟹ XP_003831170

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	98,111,412 - 98,126,571 (+)	NCBI
NHGRI_mPanPan1	17	103,013,967 - 103,024,231 (+)	NCBI
Mhudiblu_PPA_v0	17	75,974,971 - 75,993,275 (+)	NCBI
PanPan1.1	17	81,687,051 - 81,694,823 (+)	NCBI

Sequence:

show sequence

TGCCCGCAGGCCCTCTAAGAGCTGCCCAGGCTGCTGCCGCGGGTCAGAGGCGGGTCAGAGCAGG
CAGGGGGTTCATGACGCCGGCTGGGTCTGGGGGCTGTGGGCCAGCCGAGCCGACCCGGGCTTCT
GGGGGACCGCGGGGGCCGTGAGCACTCAGAGGGCGCATCCCAGGCCCCTCCGGGGACCCGGCCA
GCCTGAAGATGCCGACGAACGGCCTGCACCAGGTGCTGAAGATCCAGTTTGGCCTCGTCAACGA
CACTGACCGCTACCTGACAGCTGAGAGCTTCGGCTTCAAGGTCAATGCCTCGGCACCCAGCCTC
AAGAGGAAGCAGACCTGGGTGCTGGAACCCGACCCAGGACGAGGCACGGCTGTGCTGCTCCGCA
GCAGCCACCTGGGCCGCTACCTGTCGGCAGGAGAGGACGGGCGCGTGGCCTGCGAGGCAGAGCA
GCCGGGCCGTGACTGCCGCTTCCTGGTCCTGCCGCAGCCAGACGGGCGCTGGGTGCTGCGGTCC
GAGCCGCACGGCCGCTTCTTCGGAGGCACCGAGGACCAGCTGTCCTGCTTCGCCACAGCCGTTT
CCCCGGCCGAGCTGTGGACCGTGCACCTGGCCATCCACCCGCAGGCCCACCTGCTGAGCGTGAG
CCGGCGGCGCTACGTGCACCTGTGCCCGCGGGAGGACGAGATGGCCGCAGACGGAGACAAGCCC
TGGGGCGTGGACGCCCTCCTCACCCTCATCTTCCGGAGCCGACGGTACTGCCTCAAGTCCTGTG
ACAGCCGCTACCTGCGCAGCGACGGCCGCCTGGTCTGGGAGCCTGAGCCCCGCGCCTGCTACAC
GCTGGAGTTCAAGGCGGGCAGGCTGGCCTTCAAGGACTGCGACGGCCACTACCTGGCACCCGTG
GGGCCCGCAGGCACTCTCAAGGCCGGCCGAAACACGCGACCCGGCAAGGATGAGCTCTTTGATC
TGGAGGAGAGTCACCCACAGGTGGTGCTGGTGGCTGCCAACCACCGCTACGTCTCTGTGCGGCA
AGGGGTCAACGTCTCAGCCAATCAGGATGATGAACTAGACCACGAGACCTTCCTGATGCAAATT
GACCAGGAGACAAAGAAGTGCACCTTCTATTCCAGCACTGGGGGCTACTGGACACTGGTCACCC
ATGGGGGCATTCACGCCACAGCCACACAAGTTTCCGCCAACACCATGTTTGAGATGGAGTGGCG
TGGCCGGCGGGTAGCACTCAAAGCCAGCAATGGGCGCTACGTGTGCATGAAGAAGAATGGGCAG
CTGGCGGCTATCAGCGATTTTGTCGGCAAGGACGAAGAGTTCACCCTCAAGCTCATCAACCGGC
CCATCCTGGTGCTGCGCGGCCTGGACGGCTTCGTCTGCCACCACCGCGGCTCCAACCAGCTGGA
CACCAACCGCTCCGTCTACGACGTCTTCCACCTGAGCTTCAGCGACGGCGCCTACCACATCCGA
GGCCGCGACGGAGGGTTCTGGTACACGGGCAGCCACGGCAGCGTGTGCAGCGACGGCGAACGCG
CCGAGGACTTCGTCTTCGAGTTCCGCGAACGCGGCCGCCTGGCCATCCGCGCCCGGAGTGGCAA
GTACCTGCGCGGCGGCGCCTCGGGCCTGCTGCGGGCCGACGCCGACGCCCCGGCCGGGACCGCG
CTTTGGGAGTACTGAGGCCGCGCCCAGACCAGCCTGTCGCGCATTAAAACCGTGTCTCTCCCGC
A

hide sequence

RefSeq Acc Id:

XM_055101983 ⟹ XP_054957958

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	98,111,412 - 98,126,571 (+)	NCBI
NHGRI_mPanPan1	17	103,013,967 - 103,024,231 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003831170	(Get FASTA)	NCBI Sequence Viewer
	XP_054957958	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000038032.1

RefSeq Acc Id:

XP_003831170 ⟸ XM_003831122

- Peptide Label:

isoform X2

- Sequence:

show sequence

MPTNGLHQVLKIQFGLVNDTDRYLTAESFGFKVNASAPSLKRKQTWVLEPDPGRGTAVLLRSSH
LGRYLSAGEDGRVACEAEQPGRDCRFLVLPQPDGRWVLRSEPHGRFFGGTEDQLSCFATAVSPA
ELWTVHLAIHPQAHLLSVSRRRYVHLCPREDEMAADGDKPWGVDALLTLIFRSRRYCLKSCDSR
YLRSDGRLVWEPEPRACYTLEFKAGRLAFKDCDGHYLAPVGPAGTLKAGRNTRPGKDELFDLEE
SHPQVVLVAANHRYVSVRQGVNVSANQDDELDHETFLMQIDQETKKCTFYSSTGGYWTLVTHGG
IHATATQVSANTMFEMEWRGRRVALKASNGRYVCMKKNGQLAAISDFVGKDEEFTLKLINRPIL
VLRGLDGFVCHHRGSNQLDTNRSVYDVFHLSFSDGAYHIRGRDGGFWYTGSHGSVCSDGERAED
FVFEFRERGRLAIRARSGKYLRGGASGLLRADADAPAGTALWEY

hide sequence

Ensembl Acc Id:

ENSPPAP00000038032 ⟸ ENSPPAT00000060935

RefSeq Acc Id:	XP_054957958 ⟸ XM_055101983
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9CIL0 (UniProtKB/TrEMBL)

Protein Domains

Fascin

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000041749	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000060935.1	UniProtKB/TrEMBL
Gene3D-CATH	2.80.10.50	UniProtKB/TrEMBL
InterPro	Actin-crosslinking	UniProtKB/TrEMBL
	Fascin	UniProtKB/TrEMBL
	Fascin-domain	UniProtKB/TrEMBL
	Fascin_metazoans	UniProtKB/TrEMBL
NCBI Gene	FSCN2	ENTREZGENE
PANTHER	PTHR10551	UniProtKB/TrEMBL
	PTHR10551:SF24	UniProtKB/TrEMBL
Pfam	Fascin	UniProtKB/TrEMBL
PIRSF	Fascin	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50405	UniProtKB/TrEMBL
UniProt	A0A2R9CIL0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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