SLC7A9 (solute carrier family 7 member 9)

Gene: SLC7A9 (solute carrier family 7 member 9) Pan paniscus

Analyze

Symbol:

SLC7A9

Name:

solute carrier family 7 member 9

RGD ID:

11743218

Description:

ENCODES a protein that exhibits amino acid transmembrane transporter activity (ortholog); INVOLVED IN amino acid transport (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH cystinuria (ortholog); genetic disease (ortholog); hereditary spastic paraplegia 75 (ortholog); FOUND IN plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

B(0,+)-type amino acid transporter 1; solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	38,803,634 - 38,841,120 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	40,802,790 - 40,840,197 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	29,753,265 - 29,793,871 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	38,499,106 - 38,538,750 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	38,499,106 - 38,538,750 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cystinuria (ISO)

genetic disease (ISO)

hereditary spastic paraplegia 75 (ISO)

kidney disease (ISO)

polycystic kidney disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amino acid transmembrane transport (IEA)

amino acid transport (ISO)

basic amino acid transmembrane transport (IEA)

L-alpha-amino acid transmembrane transport (IEA)

L-cystine transport (IEA)

neutral amino acid transport (IEA)

transmembrane transport (IEA)

Cellular Component

apical plasma membrane (IEA)

brush border membrane (IEA)

membrane (IEA)

plasma membrane (ISO)

Molecular Function

amino acid transmembrane transporter activity (ISO)

antiporter activity (IEA)

broad specificity neutral L-amino acid:basic L-amino acid antiporter activity (IEA)

L-cystine transmembrane transporter activity (IEA)

neutral L-amino acid transmembrane transporter activity (IEA)

protein binding (ISO)

protein heterodimerization activity (IEA)

transmembrane transporter activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

amiloride pharmacodynamics pathway (ISO)

bendroflumethiazide pharmacodynamics pathway (ISO)

bumetanide pharmacodynamics pathway (ISO)

chlorothiazide pharmacodynamics pathway (ISO)

chlorthalidone pharmacodynamics pathway (ISO)

cystinuria pathway (ISO)

eplerenone pharmacodynamics pathway (ISO)

etacrynic acid pharmacodynamics pathway (ISO)

furosemide pharmacodynamics pathway (ISO)

Hartnup disease pathway (ISO)

hydrochlorothiazide pharmacodynamics pathway (ISO)

hydroflumethiazide pharmacodynamics pathway (ISO)

iminoglycinuria pathway (ISO)

lysinuric protein intolerance pathway (ISO)

metolazone pharmacodynamics pathway (ISO)

spironolactone pharmacodynamics pathway (ISO)

torasemide pharmacodynamics pathway (ISO)

triamterene pharmacodynamics pathway (ISO)

trichlormethiazide pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SLC7A9
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	38,803,634 - 38,841,120 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	40,802,790 - 40,840,197 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	29,753,265 - 29,793,871 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	38,499,106 - 38,538,750 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	38,499,106 - 38,538,750 (-)	Ensembl	panpan1.1		panPan2

SLC7A9
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	32,830,511 - 32,869,767 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	32,830,509 - 32,869,767 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	33,321,417 - 33,360,673 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	38,013,262 - 38,052,512 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	38,013,261 - 38,052,512	NCBI
Celera	19	30,015,026 - 30,054,305 (-)	NCBI		Celera
Cytogenetic Map	19	q13.11	NCBI
HuRef	19	29,823,977 - 29,863,313 (-)	NCBI		HuRef
CHM1_1	19	33,322,523 - 33,361,817 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	35,349,240 - 35,388,495 (-)	NCBI		T2T-CHM13v2.0

Slc7a9
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	35,148,152 - 35,165,459 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	35,148,221 - 35,165,461 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	35,448,727 - 35,466,034 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	35,448,796 - 35,466,036 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	36,234,198 - 36,251,018 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	35,157,939 - 35,174,759 (+)	NCBI		MGSCv36	mm8
Celera	7	30,576,815 - 30,593,617 (+)	NCBI		Celera
Cytogenetic Map	7	B2	NCBI
cM Map	7	21.37	NCBI

Slc7a9
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	97,246,253 - 97,269,546 (+)	NCBI		GRCr8
mRatBN7.2	1	88,109,517 - 88,132,653 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	88,110,644 - 88,132,641 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	93,515,663 - 93,538,236 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	101,981,616 - 102,004,191 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	95,273,953 - 95,296,526 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	91,709,034 - 91,738,492 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	91,716,383 - 91,738,494 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	92,836,837 - 92,865,759 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	87,976,440 - 87,999,102 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	88,054,550 - 88,077,212 (+)	NCBI
Celera	1	82,459,876 - 82,482,526 (+)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

Slc7a9
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	5,112,161 - 5,200,266 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955468	5,112,057 - 5,201,272 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC7A9
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	119,205,833 - 119,229,054 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	119,205,833 - 119,229,054 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	118,605,982 - 118,629,205 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	119,806,922 - 119,830,085 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	119,806,922 - 119,830,085 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	119,370,036 - 119,393,192 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	118,990,490 - 119,013,672 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	120,050,385 - 120,073,608 (+)	NCBI		UU_Cfam_GSD_1.0

Slc7a9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	8,701,341 - 8,730,010 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936570	2,917,709 - 2,944,158 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936570	2,917,389 - 2,944,452 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC7A9
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	42,669,093 - 42,714,267 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	42,664,795 - 42,706,113 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	38,108,038 - 38,212,965 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC7A9
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	27,877,089 - 27,919,268 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	27,876,364 - 27,908,098 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	5,462,017 - 5,493,104 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc7a9
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624794	7,761,511 - 7,792,473 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003816204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_024926748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063599541	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000057866 ⟹ ENSPPAP00000034980

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	38,499,106 - 38,538,750 (-)	Ensembl

RefSeq Acc Id:

XM_003816204 ⟹ XP_003816252

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	38,803,634 - 38,841,068 (-)	NCBI
NHGRI_mPanPan1	19	40,802,790 - 40,840,197 (-)	NCBI
Mhudiblu_PPA_v0	19	29,753,265 - 29,793,871 (-)	NCBI
PanPan1.1	19	38,499,106 - 38,538,750 (-)	NCBI

Sequence:

show sequence

CATGGCCATTTCTAGGGTTGCACCGTGCAGGCACGGGCGGTCAGCTGGGCCGCAGCTCCTCCGG
CTCTGCAGGGTCACGGAGGAAGCCAGCTCCCCTAGTCCAGGCCGAGCTTGCACTTGCGTCTTGT
CTGCTGCTGCTGAACCAAGATTTAGCTGTGCGGCCTCCTTGCAGTCTCCTGGAACCAGCAGGAG
GAAACATGGGGGATACTGGCCCGAGAAAGCGGAGAGAGGATGAGAAGTCGATCCAGAGCCAAGA
GCCTAAGACCACCAGTCTCCAAAAGGAGCTGGGCCTCATCAGTGGCATCTCCATCATCGTGGGC
ACCATCATTGGCTCTGGGATCTTCATTTCCCCCAAGTCTGTGCTCAGCAACACGGAAGCTGTGG
GGCCCTGCCTCATCATATGGGCGGCTTGCGGGGTCCTCGCGACACTGGGTGCCCTGTGCTTTGC
AGAGCTTGGCACAATGATCACCAAGTCAGGGGGAGAGTATCCCTACCTGATGGAGGCCTACGGG
CCCATCCCCGCCTACCTCTTCTCCTGGGCCAGCCTGATCGTCATCAAGCCCTCGTCCTTCGCCA
TCATCTGCCTCAGCTTCTCCGAGTATGTGTGCGCGCCCTTCTATGCGGGCTGCAAGCCTCCTCA
AATCGTTGTGAAATGCCTGGCCGCCGCCGCCATCTTGTTCATCTCGACAGTGAACTCACTGAGC
GTGCGGCTGGGAAGCTACGTCCAGAACATCTTCACTGCGGCCAAGCTGGTGATCGTGGCCATCA
TCATCATCAGCGGGCTCGTGCTCCTGGCCCAAGGAAACACAAAGAATTTTGATAATTCTTTCGA
GGGCGCCCAGCTGTCTGTGGGAGCCATCAGTCTGGCGTTTTACAATGGACTCTGGGCCTATGAT
GGATGGAATCAACTCAATTACATCACAGAAGAACTTAGAAACCCTTACAGAAACCTGCCTTTGG
CCATTATCATCGGGATCCCCCTGGTGACGGCGTGCTACATCCTCATGAACGTGTCCTACTTCAC
CGTGATGACTGCCACCGAACTCCTGCAGTCCCAGGCCGTGGCTGTGACATTTGGTGACCGTGTT
CTCTATCCTGCTTCTTGGATCGTTCCACTTTTTGTGGCATTTTCAACCATCGGTGCTGCTAACG
GGACCTGCTTCACAGCGGGCAGACTCATTTACGTGGCGGGCCGGGAGGGCCACATGCTCAAAGT
GCTTTCTTACATCAGCGTCAGGCGCCTCACTCCAGCCCCCGCCATCATCTTTTATGGTATCATA
GCAACGATTTATATCATCCCTGGTGACATAAACTCGTTAGTCAATTATTTCAGCTTTGCCGCAT
GGCTGTTTTATGGCCTGACGATTCTAGGACTCATCGTGATGAGATTTACAAGGAAAGAGCTGGA
AAGGCCTATCAAGGTGCCCATAGTCATTCCCGTCTTGGTGACACTCATCTCTGTGTTTTTGGTT
CTGGCTCCAATCATCAGCAAGCCCGCATGGGAGTACCTCTACTGTGTGCTGTTTATATTAAGCG
GCCTTTTATTTTACTTCCTGTTTGTCCACTACAAGTTTGGATGGGCTCAGAAAATCTCAAAGCC
GATTACCATGCACCTTCAGATGCTAATGGAAGTGGTCCCACCGGAGGAAGACCCTGAGTAACAA
GCTCTGCCTCTTGTAGCCAAGTCAGCTGAATTTATTTTCTTAAGCAATATTTGTGGTTATTTCT
TCCTTTTTTTCTTATGAATAAAATATACTCAGATGTTTAAAA

hide sequence

RefSeq Acc Id:

XM_063599541 ⟹ XP_063455611

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	38,803,634 - 38,841,120 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003816252	(Get FASTA)	NCBI Sequence Viewer
	XP_063455611	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000034980
	ENSPPAP00000034980.1

RefSeq Acc Id:	XP_003816252 ⟸ XM_003816204
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9C2F7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGDTGPRKRREDEKSIQSQEPKTTSLQKELGLISGISIIVGTIIGSGIFISPKSVLSNTEAVGP CLIIWAACGVLATLGALCFAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLIVIKPSSFAII CLSFSEYVCAPFYAGCKPPQIVVKCLAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAIII ISGLVLLAQGNTKNFDNSFEGAQLSVGAISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPLAI IIGIPLVTACYILMNVSYFTVMTATELLQSQAVAVTFGDRVLYPASWIVPLFVAFSTIGAANGT CFTAGRLIYVAGREGHMLKVLSYISVRRLTPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWL FYGLTILGLIVMRFTRKELERPIKVPIVIPVLVTLISVFLVLAPIISKPAWEYLYCVLFILSGL LFYFLFVHYKFGWAQKISKPITMHLQMLMEVVPPEEDPE hide sequence

RefSeq Acc Id:

ENSPPAP00000034980 ⟸ ENSPPAT00000057866

RefSeq Acc Id:	XP_063455611 ⟸ XM_063599541
- Peptide Label:	isoform X1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000040321	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000057866.1	UniProtKB/TrEMBL
Gene3D-CATH	Amino acid/polyamine transporter I	UniProtKB/TrEMBL
InterPro	AA/rel_permease1	UniProtKB/TrEMBL
KEGG Report	pps:100992410	UniProtKB/TrEMBL
NCBI Gene	SLC7A9	ENTREZGENE
PANTHER	AMINO ACID TRANSPORTER	UniProtKB/TrEMBL
	B(0,+)-TYPE AMINO ACID TRANSPORTER 1	UniProtKB/TrEMBL
Pfam	AA_permease_2	UniProtKB/TrEMBL
PIRSF	AA_transporter	UniProtKB/TrEMBL
UniProt	A0A2R9C2F7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB