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Gene: MYL12B (myosin light chain 12B) Pan paniscus

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Symbol:

MYL12B

Name:

myosin light chain 12B

RGD ID:

11734397

Description:

ENCODES a protein that exhibits GTPase binding (ortholog); myosin heavy chain binding (ortholog); INVOLVED IN regulation of cell shape (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); ovarian serous cystadenocarcinoma (ortholog); stomach cancer (ortholog); FOUND IN apical part of cell (ortholog); brush border (ortholog); cell cortex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC100977910; myosin regulatory light chain 12B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	35,162,868 - 35,179,082 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	20,855,526 - 20,871,861 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	10,999,849 - 11,016,059 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	13,308,356 - 13,324,754 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	13,308,356 - 13,324,754 (-)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hepatocellular carcinoma (ISO)

ovarian serous cystadenocarcinoma (ISO)

stomach cancer (ISO)

urinary bladder cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of cell shape (ISO)

Cellular Component

apical part of cell (ISO)

brush border (ISO)

cell cortex (ISO)

myosin II complex (ISO)

protein-containing complex (ISO)

stress fiber (ISO)

Z disc (ISO)

Molecular Function

calcium ion binding (IEA)

GTPase binding (ISO)

myosin heavy chain binding (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

MYL12B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	35,162,868 - 35,179,082 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	20,855,526 - 20,871,861 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	10,999,849 - 11,016,059 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	13,308,356 - 13,324,754 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	13,308,356 - 13,324,754 (-)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

MYL12B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	3,262,133 - 3,278,461 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	3,261,479 - 3,278,461 (+)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	18	3,262,131 - 3,278,459 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	3,252,135 - 3,268,179 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	18	3,141,594 - 3,157,815 (+)	NCBI		Celera
Cytogenetic Map	18	p11.31	NCBI
HuRef	18	3,226,523 - 3,243,194 (+)	NCBI		HuRef
CHM1_1	18	3,261,491 - 3,277,645 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	3,421,438 - 3,437,816 (+)	NCBI		T2T-CHM13v2.0

Myl12b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	71,280,958 - 71,297,511 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	71,280,119 - 71,297,959 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	70,973,963 - 70,990,516 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	70,973,133 - 70,990,890 (-)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	17	71,323,303 - 71,339,856 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	70,878,820 - 70,895,373 (-)	NCBI		MGSCv36	mm8
Celera	17	75,244,495 - 75,261,050 (-)	NCBI		Celera
Cytogenetic Map	17	E1.3	NCBI
cM Map	17	41.87	NCBI

Myl12b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	118,320,479 - 118,334,810 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	118,320,489 - 118,324,418 (-)	Ensembl				GRCr8
mRatBN7.2	9	110,873,855 - 110,888,187 (-)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	9	119,261,365 - 119,275,700 (-)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	124,390,953 - 124,405,288 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	122,727,332 - 122,741,665 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	9	121,908,708 - 121,923,054 (-)	NCBI
Lyon_Normotensive	9	117,757,364 - 117,771,705 (-)	NCBI
Lyon_Hypertensive	9	117,885,333 - 117,899,666 (-)	NCBI
F344_StmMcwi	9	119,862,815 - 119,877,148 (-)	NCBI
Rnor_6.0	9	119,307,168 - 119,321,500 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	119,307,176 - 119,321,500 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	9	118,761,452 - 118,775,834 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	110,171,418 - 110,186,248 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	108,004,122 - 108,018,394 (-)	NCBI		Celera
RGSC_v3.1	9	110,380,900 - 110,384,839 (-)	NCBI
Cytogenetic Map	9	q38	NCBI

MYL12B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	69,877,727 - 69,895,196 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	69,332,485 - 69,350,491 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	69,938,422 - 69,954,234 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	69,939,041 - 69,957,106 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	69,621,752 - 69,639,768 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	69,640,728 - 69,658,745 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	69,939,371 - 69,957,614 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

LOC101966654
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	13	51,255,712 - 51,273,974 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024404944	66,219,949 - 66,238,423 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936672	1,300,341 - 1,322,065 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936672	1,303,510 - 1,321,969 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC733637
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	103,409,717 - 103,420,286 (-)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	6	103,413,841 - 103,424,790 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	96,440,639 - 96,451,618 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103222701
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	18	64,943,836 - 64,961,143 (+)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666050	37,373,059 - 37,390,346 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	18	62,510,012 - 62,527,027 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	62,521,295 - 62,529,131 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

Myl12b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624770	13,378,668 - 13,408,633 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
HetGla_female_1.0 Ensembl	NW_004624770	13,393,106 - 13,409,139 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla_female_1.0 Ensembl	NW_004624770	13,386,194 - 13,392,928 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl	18	60,025,081 - 60,030,727 (+)	Ensembl
Naked mole-rat maternal Ensembl	18	60,006,176 - 60,011,788 (+)	Ensembl

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003817891	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034943651	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000018297 ⟹ ENSPPAP00000003949

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	18	13,308,356 - 13,324,754 (-)	Ensembl

RefSeq Acc Id:

XM_003817891 ⟹ XP_003817939

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	17	35,162,868 - 35,179,082 (-)	NCBI
NHGRI_mPanPan1	18	20,855,526 - 20,871,861 (-)	NCBI
Mhudiblu_PPA_v0	18	10,999,871 - 11,016,059 (-)	NCBI
PanPan1.1	18	13,308,356 - 13,324,754 (-)	NCBI

Sequence:

show sequence

GGTGGCGGAGCTACCAAAGGAGCGGGGGACGAGGGCCGGGCTGCGGGCGACCGCCGCAGCGCAG
GCCGCGATATCGCAGCGGATCGGAGCAGGCCGGAGGGGCAATTAAGACCCCGGCCGTGTGCGTC
CGGCCTCAGCAGCCCCGCCGCTCGGCGGACAAGCAGACCCCGCCGGCCCGGGCGCGAACACTCA
GCGCACCCCCGTTCCACTTGGTCCCGCCGAGCCTTCCGGTGCGCCTTCCGCTCCGCCCCTTCAG
GCAGGAAGTGTCGGCGCCGCCACTGTCCGGCCACAGCCTAACGCTCTTCGCCGTCGTTTGTGGT
CTCGCGCAGGGCGGCCCCGGTTCTGGTGTTTGGCGTTGGAATTAAACAACCACCATGTCGAGCA
AAAAGGCAAAGACCAAGACCACCAAGAAGCGCCCTCAGCGCGCAACATCCAATGTGTTTGCCAT
GTTTGACCAGTCACAGATTCAGGAGTTCAAAGAGGCCTTCAACATGATTGATCAGAACAGAGAT
GGCTTCATCGACAAGGAAGATTTGCATGATATGCTTGCTTCTCTAGGGAAGAATCCCACTGATG
CATACCTTGATGCCATGATGAATGAGGCCCCAGGGCCCATCAATTTCACCATGTTCCTGACCAT
GTTTGGTGAGAAGTTAAATGGCACAGATCCTGAAGATGTCATCAGAAACGCCTTTGCTTGCTTT
GATGAAGAAGCAACAGGCACCATTCAGGAAGATTACCTAAGAGAGCTGCTGACAACCATGGGGG
ATCGGTTTACAGATGAGGAAGTGGATGAGCTGTACAGAGAAGCACCTATTGACAAAAAGGGGAA
TTTCAATTACATCGAGTTCACACGCATCCTGAAACATGGAGCCAAAGACAAAGATGACTGAAAG
AACTTTAGCTAAAATCTTCCAGTTACATTGTCTTACTCTCTTTTATTTCTCAGACACTTCCCCC
ACCCTCATAGAACCTGTTGCATGCAACTTAGTTTCACAGCTTTGCCTCTTCTTTTTGATGTATT
TATTCCAGACCTTTCTGCCACTTAGCACTTGTATAATCAGACTGGAAATGGGGATGAGGGTGTA
AATTGTATTGAAAAAGAGATCGCGAATAAAAATCAACAAATGTGAAAGCCCAGAAAAATATATT
CGTATTTCTGGTTTTGCTGGATTTTTACATTTTTATATAATAAAAATGTTATTTTGAAATAAAG
ATTATGCTGACTCAAA

hide sequence

RefSeq Acc Id:

XM_034943651 ⟹ XP_034799542

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	17	35,162,868 - 35,178,567 (-)	NCBI
NHGRI_mPanPan1	18	20,855,526 - 20,871,199 (-)	NCBI
Mhudiblu_PPA_v0	18	10,999,849 - 11,015,540 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003817939	(Get FASTA)	NCBI Sequence Viewer
	XP_034799542	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000003949.1
	ENSPPAP00050014472

RefSeq Acc Id:	XP_003817939 ⟸ XM_003817891
- UniProtKB:	A0A2R8ZG22 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSSKKAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKN PTDAYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLT TMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD hide sequence

RefSeq Acc Id:	XP_034799542 ⟸ XM_034943651
- UniProtKB:	A0A2R8ZG22 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSPPAP00000003949 ⟸ ENSPPAT00000018297

Protein Domains

EF-hand

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000016699	Ensembl, UniProtKB/TrEMBL
	ENSPPAG00050011096	ENTREZGENE
Ensembl Transcript	ENSPPAT00000018297.1	UniProtKB/TrEMBL
	ENSPPAT00050023259	ENTREZGENE
Gene3D-CATH	EF-hand	UniProtKB/TrEMBL
InterPro	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/TrEMBL
	EF_hand_DJBP	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
	Myosin_RLC	UniProtKB/TrEMBL
KEGG Report	pps:100977910	UniProtKB/TrEMBL
NCBI Gene	MYL12B	ENTREZGENE
PANTHER	MYOSIN REGULATORY LIGHT CHAIN 2	UniProtKB/TrEMBL
Pfam	EF-hand_11	UniProtKB/TrEMBL
	EF-hand_7	UniProtKB/TrEMBL
PROSITE	EF_HAND_1	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
SMART	EFh	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47473	UniProtKB/TrEMBL
UniProt	A0A2R8ZG22	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-03-13	MYL12B	myosin light chain 12B	LOC100977910	myosin regulatory light chain 12B	Symbol and/or name change	5135510	APPROVED
2020-07-01	LOC100977910	myosin regulatory light chain 12B	MYL12B	myosin light chain 12B	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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