TSFM (Ts translation elongation factor, mitochondrial) - Rat Genome Database

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Gene: TSFM (Ts translation elongation factor, mitochondrial) Pan paniscus
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Symbol: TSFM
Name: Ts translation elongation factor, mitochondrial
RGD ID: 11730513
Description: ENCODES a protein that exhibits protein-lysine N-methyltransferase activity (ortholog); INVOLVED IN peptidyl-lysine methylation (ortholog); ASSOCIATED WITH cataract 15 multiple types (ortholog); Charcot-Marie-Tooth disease axonal type 2U (ortholog); combined oxidative phosphorylation deficiency (ortholog); FOUND IN cytosol (inferred); mitochondrion (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: EEF1A lysine methyltransferase 3; EEF1AKMT3; elongation factor Ts, mitochondrial; methyltransferase like 21B; METTL21B; protein-lysine methyltransferase METTL21B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21036,536,392 - 36,558,355 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11236,534,418 - 36,565,211 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,123,500 - 31,154,310 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,404,044 - 31,414,606 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,404,783 - 31,415,595 (-)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl1231,379,302 - 31,404,578 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TSFM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21036,536,392 - 36,558,355 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11236,534,418 - 36,565,211 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,123,500 - 31,154,310 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,404,044 - 31,414,606 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,404,783 - 31,415,595 (-)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl1231,379,302 - 31,404,578 (-)Ensemblpanpan1.1panPan2
TSFM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,782,787 - 57,802,856 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1257,782,761 - 57,808,071 (+)EnsemblGRCh38hg38GRCh38
GRCh371258,176,570 - 58,196,639 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,462,826 - 56,476,784 (+)NCBINCBI36Build 36hg18NCBI36
Build 341256,462,825 - 56,476,784NCBI
Celera1257,834,139 - 57,854,561 (+)NCBICelera
Cytogenetic Map12q14.1NCBI
HuRef1255,213,385 - 55,233,606 (+)NCBIHuRef
CHM1_11258,144,334 - 58,164,430 (+)NCBICHM1_1
T2T-CHM13v2.01257,751,155 - 57,771,225 (+)NCBIT2T-CHM13v2.0
Eef1akmt3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910126,868,654 - 126,877,883 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10126,866,873 - 126,877,382 (-)EnsemblGRCm39 Ensembl
GRCm3810127,032,806 - 127,042,014 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,031,004 - 127,041,513 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710126,435,854 - 126,444,884 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,435,854 - 126,444,884 (-)NCBIMGSCv36mm8
Celera10129,424,819 - 129,433,834 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.5NCBI
Eef1akmt3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8764,738,726 - 64,749,904 (-)NCBIGRCr8
mRatBN7.2762,853,304 - 62,864,558 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl762,854,899 - 62,864,617 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0770,320,845 - 70,328,452 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,321,077 - 70,328,148 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,496,662 - 70,506,136 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera759,998,896 - 60,007,857 (-)NCBICelera
Cytogenetic Map7q22NCBI
Eef1akmt3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554585,482,548 - 5,487,615 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,482,524 - 5,488,040 (+)NCBIChiLan1.0ChiLan1.0
EEF1AKMT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,833,759 - 1,842,646 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,897,885 - 1,905,595 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0101,844,101 - 1,852,283 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1101,821,796 - 1,829,934 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0102,063,859 - 2,071,600 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0102,188,754 - 2,196,859 (+)NCBIUU_Cfam_GSD_1.0
Eef1akmt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494556,952,832 - 56,961,638 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,908,619 - 1,917,330 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366461,908,581 - 1,917,376 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EEF1AKMT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl523,063,109 - 23,072,849 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1523,063,114 - 23,087,009 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
EEF1AKMT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,685,432 - 53,695,666 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,686,085 - 53,693,779 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037192,265,808 - 192,276,043 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eef1akmt3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480210,164,844 - 10,171,639 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480210,163,086 - 10,171,665 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000028539   ⟹   ENSPPAP00000006812
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1231,404,783 - 31,414,606 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000028544   ⟹   ENSPPAP00000006813
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1231,407,047 - 31,415,595 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000028548   ⟹   ENSPPAP00000006816
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1231,407,047 - 31,414,446 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000064581   ⟹   ENSPPAP00000041655
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1231,379,302 - 31,404,522 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000064582   ⟹   ENSPPAP00000041656
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1231,384,598 - 31,404,522 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000064585   ⟹   ENSPPAP00000041659
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1231,384,644 - 31,404,522 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000064587   ⟹   ENSPPAP00000041661
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1231,389,647 - 31,404,578 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000064589   ⟹   ENSPPAP00000041663
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1231,390,640 - 31,404,522 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000064592   ⟹   ENSPPAP00000041666
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1231,391,026 - 31,404,522 (-)Ensembl
RefSeq Acc Id: XM_003824828   ⟹   XP_003824876
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21036,544,071 - 36,558,324 (-)NCBI
NHGRI_mPanPan11236,540,841 - 36,565,116 (-)NCBI
Mhudiblu_PPA_v01231,129,945 - 31,154,109 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008978468   ⟹   XP_008976716
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21036,536,392 - 36,558,355 (-)NCBI
NHGRI_mPanPan11236,534,418 - 36,565,116 (-)NCBI
Mhudiblu_PPA_v01231,123,500 - 31,154,109 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063593379   ⟹   XP_063449449
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21036,544,071 - 36,558,330 (-)NCBI
RefSeq Acc Id: XM_063593380   ⟹   XP_063449450
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21036,544,071 - 36,558,330 (-)NCBI
RefSeq Acc Id: XP_008976716   ⟸   XM_008978468
- Peptide Label: isoform X3
- UniProtKB: A0A2R9CI70 (UniProtKB/TrEMBL),   A0A2R9CI98 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003824876   ⟸   XM_003824828
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CI74 (UniProtKB/TrEMBL),   A0A2R9CKY0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000041666   ⟸   ENSPPAT00000064592
Ensembl Acc Id: ENSPPAP00000041659   ⟸   ENSPPAT00000064585
Ensembl Acc Id: ENSPPAP00000041656   ⟸   ENSPPAT00000064582
Ensembl Acc Id: ENSPPAP00000041655   ⟸   ENSPPAT00000064581
Ensembl Acc Id: ENSPPAP00000041663   ⟸   ENSPPAT00000064589
Ensembl Acc Id: ENSPPAP00000041661   ⟸   ENSPPAT00000064587
Ensembl Acc Id: ENSPPAP00000006813   ⟸   ENSPPAT00000028544
Ensembl Acc Id: ENSPPAP00000006816   ⟸   ENSPPAT00000028548
Ensembl Acc Id: ENSPPAP00000006812   ⟸   ENSPPAT00000028539
RefSeq Acc Id: XP_063449449   ⟸   XM_063593379
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063449450   ⟸   XM_063593380
- Peptide Label: isoform X2
Protein Domains
Translation elongation factor EFTs/EF1B


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000025733 Ensembl, UniProtKB/TrEMBL
  ENSPPAG00000043428 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000028544.1 UniProtKB/TrEMBL
  ENSPPAT00000028548.1 UniProtKB/TrEMBL
  ENSPPAT00000064581.1 UniProtKB/TrEMBL
  ENSPPAT00000064582.1 UniProtKB/TrEMBL
  ENSPPAT00000064585.1 UniProtKB/TrEMBL
  ENSPPAT00000064587.1 UniProtKB/TrEMBL
  ENSPPAT00000064589.1 UniProtKB/TrEMBL
  ENSPPAT00000064592.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.479.20 UniProtKB/TrEMBL
  3.40.50.150 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro EF-Ts_dimer_sf UniProtKB/TrEMBL
  Methyltransf_16 UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/TrEMBL
  Transl_elong_EFTs/EF1B UniProtKB/TrEMBL
  Transl_elong_EFTs/EF1B_dimer UniProtKB/TrEMBL
  Transl_elong_Ts_CS UniProtKB/TrEMBL
  UBA-like_sf UniProtKB/TrEMBL
KEGG Report pps:100973237 UniProtKB/TrEMBL
NCBI Gene METTL21B ENTREZGENE
PANTHER EEF1A LYSINE METHYLTRANSFERASE 3 UniProtKB/TrEMBL
  ELONGATION FACTOR TS, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR11741 UniProtKB/TrEMBL
  PTHR14614 UniProtKB/TrEMBL
Pfam EF_TS UniProtKB/TrEMBL
  Methyltransf_16 UniProtKB/TrEMBL
PROSITE EF_TS_1 UniProtKB/TrEMBL
  EF_TS_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF46934 UniProtKB/TrEMBL
  SSF53335 UniProtKB/TrEMBL
  SSF54713 UniProtKB/TrEMBL
UniProt A0A2R8ZPE6_PANPA UniProtKB/TrEMBL
  A0A2R8ZSG4_PANPA UniProtKB/TrEMBL
  A0A2R9CI70 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CI74 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CI79_PANPA UniProtKB/TrEMBL
  A0A2R9CI94_PANPA UniProtKB/TrEMBL
  A0A2R9CI98 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CKY0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-03-13 TSFM  Ts translation elongation factor, mitochondrial  EEF1AKMT3  EEF1A lysine methyltransferase 3  Symbol and/or name change 5135510 APPROVED
2020-06-11 EEF1AKMT3  EEF1A lysine methyltransferase 3  TSFM  Ts translation elongation factor, mitochondrial  Data merged from RGD:11734198 737654 PROVISIONAL
2017-02-21 EEF1AKMT3  EEF1A lysine methyltransferase 3  METTL21B  methyltransferase like 21B  Symbol and/or name change 5135510 APPROVED