TNRC6B (trinucleotide repeat containing adaptor 6B) - Rat Genome Database

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Gene: TNRC6B (trinucleotide repeat containing adaptor 6B) Pan paniscus
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Symbol: TNRC6B
Name: trinucleotide repeat containing adaptor 6B
RGD ID: 11712554
Description: ENCODES a protein that exhibits nucleic acid binding (inferred); RNA binding (inferred); INVOLVED IN miRNA-mediated gene silencing by inhibition of translation (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); autism spectrum disorder (ortholog); Developmental Disabilities (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred); P-body (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: trinucleotide repeat containing 6B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22349,891,090 - 50,181,077 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12252,577,475 - 52,875,556 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02221,149,646 - 21,240,006 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12238,969,663 - 39,058,432 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2238,850,107 - 39,045,914 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)
nucleoplasm  (IEA)
P-body  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TNRC6B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22349,891,090 - 50,181,077 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12252,577,475 - 52,875,556 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02221,149,646 - 21,240,006 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12238,969,663 - 39,058,432 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2238,850,107 - 39,045,914 (+)Ensemblpanpan1.1panPan2
TNRC6B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,044,834 - 40,335,808 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2240,044,817 - 40,335,808 (+)EnsemblGRCh38hg38GRCh38
GRCh372240,440,838 - 40,731,812 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,770,767 - 39,061,758 (+)NCBINCBI36Build 36hg18NCBI36
Build 342238,898,445 - 39,043,860NCBI
Celera2224,242,863 - 24,533,872 (+)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2223,404,077 - 23,694,839 (+)NCBIHuRef
CHM1_12240,400,124 - 40,690,692 (+)NCBICHM1_1
T2T-CHM13v2.02240,516,397 - 40,807,210 (+)NCBIT2T-CHM13v2.0
Tnrc6b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391580,595,514 - 80,825,287 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1580,595,514 - 80,825,286 (+)EnsemblGRCm39 Ensembl
GRCm381580,711,313 - 80,941,086 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1580,711,313 - 80,941,085 (+)EnsemblGRCm38mm10GRCm38
MGSCv371580,541,743 - 80,771,516 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361580,538,568 - 80,768,341 (+)NCBIMGSCv36mm8
Celera1582,831,358 - 83,061,497 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.91NCBI
Tnrc6b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87114,132,574 - 114,350,010 (+)NCBIGRCr8
mRatBN7.27112,252,351 - 112,469,829 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,252,359 - 112,461,790 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7114,007,948 - 114,225,403 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07116,231,483 - 116,448,945 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07116,200,854 - 116,418,318 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,930,610 - 122,147,934 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,930,615 - 122,147,934 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,922,421 - 122,139,717 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,993,653 - 119,212,958 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17119,193,462 - 119,235,531 (+)NCBI
Celera7108,576,591 - 108,793,423 (+)NCBICelera
Cytogenetic Map7q34NCBI
Tnrc6b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,886,077 - 26,048,546 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541325,820,428 - 26,060,681 (+)NCBIChiLan1.0ChiLan1.0
TNRC6B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11024,852,168 - 25,094,400 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1024,813,854 - 25,094,393 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1024,787,185 - 25,030,572 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01025,602,650 - 25,846,409 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1025,602,509 - 25,846,331 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11025,314,565 - 25,558,084 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01025,637,095 - 25,880,678 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01025,811,506 - 26,055,123 (-)NCBIUU_Cfam_GSD_1.0
Tnrc6b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049458,451,252 - 8,687,007 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364921,461,533 - 1,631,165 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364921,461,572 - 1,697,500 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNRC6B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl58,063,985 - 8,311,429 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.158,052,434 - 8,311,811 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.255,418,164 - 5,430,080 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNRC6B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11922,823,447 - 22,907,942 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1922,823,937 - 22,898,476 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045102,681,707 - 102,976,263 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnrc6b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247528,137,532 - 8,336,877 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247528,125,472 - 8,394,809 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000033310   ⟹   ENSPPAP00000010659
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2238,850,107 - 39,045,914 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000033318   ⟹   ENSPPAP00000010666
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2238,902,168 - 39,045,914 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000033320   ⟹   ENSPPAP00000010668
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2238,902,168 - 39,045,914 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000033325   ⟹   ENSPPAP00000010673
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2238,981,755 - 39,045,914 (+)Ensembl
RefSeq Acc Id: XM_008975121   ⟹   XP_008973369
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22350,021,117 - 50,181,077 (+)NCBI
NHGRI_mPanPan12252,714,948 - 52,875,556 (+)NCBI
Mhudiblu_PPA_v02221,149,647 - 21,240,006 (+)NCBI
PanPan1.12238,969,663 - 39,058,429 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008975122   ⟹   XP_008973370
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22350,021,118 - 50,181,077 (+)NCBI
NHGRI_mPanPan12252,714,943 - 52,875,556 (+)NCBI
Mhudiblu_PPA_v02221,150,364 - 21,239,696 (+)NCBI
PanPan1.12238,969,663 - 39,058,432 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008975123   ⟹   XP_008973371
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22350,021,115 - 50,181,077 (+)NCBI
NHGRI_mPanPan12252,714,943 - 52,875,556 (+)NCBI
Mhudiblu_PPA_v02221,150,364 - 21,240,006 (+)NCBI
PanPan1.12238,969,663 - 39,058,429 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055105367   ⟹   XP_054961342
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22349,891,090 - 50,181,077 (+)NCBI
NHGRI_mPanPan12252,577,475 - 52,875,556 (+)NCBI
RefSeq Acc Id: XM_055105370   ⟹   XP_054961345
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22349,953,745 - 50,181,077 (+)NCBI
NHGRI_mPanPan12252,645,407 - 52,875,556 (+)NCBI
RefSeq Acc Id: XM_055105372   ⟹   XP_054961347
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22349,891,090 - 50,181,077 (+)NCBI
NHGRI_mPanPan12252,577,475 - 52,875,556 (+)NCBI
RefSeq Acc Id: XM_055105374   ⟹   XP_054961349
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22349,891,090 - 50,181,077 (+)NCBI
NHGRI_mPanPan12252,577,475 - 52,875,556 (+)NCBI
RefSeq Acc Id: XM_055105375   ⟹   XP_054961350
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22349,891,523 - 50,181,077 (+)NCBI
NHGRI_mPanPan12252,582,845 - 52,875,556 (+)NCBI
RefSeq Acc Id: XM_055105376   ⟹   XP_054961351
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22349,891,495 - 50,181,077 (+)NCBI
NHGRI_mPanPan12252,582,817 - 52,875,556 (+)NCBI
RefSeq Acc Id: XM_055105377   ⟹   XP_054961352
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22349,891,470 - 50,181,077 (+)NCBI
NHGRI_mPanPan12252,582,792 - 52,875,556 (+)NCBI
RefSeq Acc Id: XM_063603313   ⟹   XP_063459383
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22350,021,116 - 50,181,077 (+)NCBI
RefSeq Acc Id: XM_063603314   ⟹   XP_063459384
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22349,891,090 - 50,181,077 (+)NCBI
RefSeq Acc Id: XP_008973371   ⟸   XM_008975123
- Peptide Label: isoform X3
- UniProtKB: A0A2R9A085 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008973369   ⟸   XM_008975121
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_008973370   ⟸   XM_008975122
- Peptide Label: isoform X8
- UniProtKB: A0A2R9A1E8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000010673   ⟸   ENSPPAT00000033325
Ensembl Acc Id: ENSPPAP00000010668   ⟸   ENSPPAT00000033320
Ensembl Acc Id: ENSPPAP00000010666   ⟸   ENSPPAT00000033318
Ensembl Acc Id: ENSPPAP00000010659   ⟸   ENSPPAT00000033310
RefSeq Acc Id: XP_054961347   ⟸   XM_055105372
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054961342   ⟸   XM_055105367
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054961349   ⟸   XM_055105374
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054961352   ⟸   XM_055105377
- Peptide Label: isoform X7
RefSeq Acc Id: XP_054961351   ⟸   XM_055105376
- Peptide Label: isoform X7
RefSeq Acc Id: XP_054961350   ⟸   XM_055105375
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054961345   ⟸   XM_055105370
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063459384   ⟸   XM_063603314
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063459383   ⟸   XM_063603313
- Peptide Label: isoform X5
Protein Domains
Argonaute hook   TNRC6 PABC binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028514 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000033310.1 UniProtKB/TrEMBL
  ENSPPAT00000033318.1 UniProtKB/TrEMBL
  ENSPPAT00000033320.1 UniProtKB/TrEMBL
  ENSPPAT00000033325.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
InterPro Argonaute_hook_dom UniProtKB/TrEMBL
  GW182_domain UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  TNRC6_PABC-bd UniProtKB/TrEMBL
  TNRC6B_RRM UniProtKB/TrEMBL
NCBI Gene TNRC6B ENTREZGENE
PANTHER PTHR13020:SF32 UniProtKB/TrEMBL
  TRINUCLEOTIDE REPEAT-CONTAINING GENE 6 UniProtKB/TrEMBL
Pfam Ago_hook UniProtKB/TrEMBL
  TNRC6-PABC_bdg UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A2R9A085 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A1E8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A1F8_PANPA UniProtKB/TrEMBL
  A0A2R9A4J5_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-15 TNRC6B  trinucleotide repeat containing adaptor 6B    trinucleotide repeat containing 6B  Symbol and/or name change 5135510 APPROVED