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Gene: HIBADH (3-hydroxyisobutyrate dehydrogenase) Pan paniscus

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Symbol:

HIBADH

Name:

3-hydroxyisobutyrate dehydrogenase

RGD ID:

11704981

Description:

ENCODES a protein that exhibits 3-hydroxyisobutyrate dehydrogenase activity (inferred); NAD binding (inferred); NADP binding (inferred); INVOLVED IN branched-chain amino acid catabolic process (inferred); valine catabolic process (inferred); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH pleomorphic xanthoastrocytoma (ortholog); FOUND IN mitochondrion (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

3-hydroxyisobutyrate dehydrogenase, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	32,350,862 - 32,487,161 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	80,675,588 - 80,811,869 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	28,166,127 - 28,299,845 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	27,763,021 - 27,896,598 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	27,763,021 - 27,896,598 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

pleomorphic xanthoastrocytoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

branched-chain amino acid catabolic process (IEA)

valine catabolic process (IEA)

Cellular Component

mitochondrion (IEA,ISO)

Molecular Function

3-hydroxyisobutyrate dehydrogenase activity (IEA)

NAD binding (IEA)

NADP binding (IEA)

oxidoreductase activity (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway (ISO)

3-hydroxyisobutyric aciduria pathway (ISO)

3-methylcrotonyl CoA carboxylase 1 deficiency pathway (ISO)

3-methylglutaconic aciduria type 1 pathway (ISO)

3-methylglutaconic aciduria type 3 pathway (ISO)

isobutyryl-CoA dehydrogenase deficiency pathway (ISO)

isovaleric acidemia pathway (ISO)

maple syrup urine disease pathway (ISO)

methylmalonate semialdehyde dehydrogenase deficiency pathway (ISO)

methylmalonic acidemia pathway (ISO)

propionic acidemia pathway (ISO)

valine, leucine and isoleucine degradation pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

HIBADH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	32,350,862 - 32,487,161 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	80,675,588 - 80,811,869 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	28,166,127 - 28,299,845 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	27,763,021 - 27,896,598 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	27,763,021 - 27,896,598 (-)	Ensembl	panpan1.1		panPan2

HIBADH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	27,525,442 - 27,662,883 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	27,525,442 - 27,662,883 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	27,565,061 - 27,702,502 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	27,531,586 - 27,669,127 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	27,338,302 - 27,475,842	NCBI
Celera	7	27,553,696 - 27,691,196 (-)	NCBI		Celera
Cytogenetic Map	7	p15.2	NCBI
HuRef	7	27,445,802 - 27,583,281 (-)	NCBI		HuRef
CHM1_1	7	27,565,079 - 27,702,664 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	27,661,820 - 27,799,261 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	27,616,251 - 27,753,745 (-)	NCBI

Hibadh
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	52,523,215 - 52,617,285 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	52,523,213 - 52,617,374 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	52,546,230 - 52,640,300 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	52,546,228 - 52,640,389 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	52,496,224 - 52,590,294 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	52,475,808 - 52,569,878 (-)	NCBI		MGSCv36	mm8
Celera	6	53,069,543 - 53,163,491 (-)	NCBI		Celera
Cytogenetic Map	6	B3	NCBI
cM Map	6	25.6	NCBI

Hibadh
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	82,979,759 - 83,077,819 (-)	NCBI		GRCr8
mRatBN7.2	4	81,649,180 - 81,747,244 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	81,649,175 - 81,780,617 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	86,863,552 - 86,961,661 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	82,638,929 - 82,737,036 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	81,065,988 - 81,164,230 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	82,604,369 - 82,702,429 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	82,604,373 - 82,702,429 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	147,270,733 - 147,368,793 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	80,850,300 - 80,948,361 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	81,134,949 - 81,232,983 (-)	NCBI
Celera	4	76,531,774 - 76,629,846 (-)	NCBI		Celera
Cytogenetic Map	4	q24	NCBI

Hibadh
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955410	29,180,184 - 29,294,315 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955410	29,180,411 - 29,294,273 (-)	NCBI	ChiLan1.0	ChiLan1.0

HIBADH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	40,672,294 - 40,780,608 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	40,673,008 - 40,780,516 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	40,103,065 - 40,211,269 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	40,612,124 - 40,720,480 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	14	40,724,156 - 40,832,851 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	40,410,011 - 40,517,904 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	40,768,329 - 40,876,417 (-)	NCBI		UU_Cfam_GSD_1.0

Hibadh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	84,907,096 - 85,008,177 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936478	4,118,752 - 4,219,908 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HIBADH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	44,985,425 - 45,208,347 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	44,985,410 - 45,102,171 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	49,444,226 - 49,485,380 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HIBADH
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	30,708,862 - 30,848,158 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	30,708,943 - 30,848,332 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	73,892,111 - 74,031,577 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hibadh
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624739	2,964,982 - 3,078,074 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624739	2,965,096 - 3,077,810 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003807898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000062654 ⟹ ENSPPAP00000039742

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	27,763,021 - 27,896,598 (-)	Ensembl

RefSeq Acc Id:

XM_003807898 ⟹ XP_003807946

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	32,350,862 - 32,487,161 (-)	NCBI
NHGRI_mPanPan1	7	80,675,588 - 80,811,869 (-)	NCBI
Mhudiblu_PPA_v0	7	28,166,127 - 28,299,845 (-)	NCBI
PanPan1.1	7	27,763,021 - 27,896,598 (-)	NCBI

Sequence:

show sequence

GGATTGACAGGCCCTGCCGCGTCAGGCCGCTCCTCTCGGCTCCGCACTCCTTCCCTCGCGCGTG
GGCACCCGCCCCCGAGCGGTGAGAGCGCGTGCGCGCGCGCCCTTCTCCGTGGGCGAGCCAGGCA
GTCCCGCTGCACACGCTCGCAGTCTGTGGGCCCTCCGGGAGGCGGCGGAGGTCACCGCGGGGAG
AGGGGCGGGGGCAGCATGGCAGCCTCCTTACGGCTCCTCGGAGCTGCCTCCGGTCTCCGGTACT
GGAGCCGGCGGCTGCGGCCGGCAGCCGGCAGCTTTGCAGCGGTGTGTTCTAGGTCAGTGGCTTC
AAAGACTCCAGTTGGATTCATTGGACTGGGCAACATGGGGAATCCAATGGCAAAAAATCTCATG
AAACATGGCTATCCACTTATTATTTATGATGTGTTCCCTGATGCCTGCAAAGAGTTTCAAGATG
CAGGTGAACAGGTAGTATCTTCCCCAGCAGATGTTGCTGAAAAAGCTGACAGAATTATTACAAT
GCTGCCCACCAGTATCAATGCAATAGAAGCTTATTCCGGAGCAAATGGGATTCTAAAGAAAGTG
AAGAAGGGCTCATTATTAATAGATTCCAGCACTATTGATCCTGCAGTTTCAAAAGAATTGGCCA
AAGAAGTTGAGAAAATGGGAGCAGTTTTCATGGATGCCCCTGTTTCTGGTGGTGTAGGAGCTGC
ACGATCTGGGAACCTCACGTTTATGGTGGGAGGAGTTGAAGATGAATTTGCTGCTGCCCAAGAG
TTGCTGGGGTGCATGGGCTCCAACGTGGTGTACTGTGGAGCTGTTGGGACTGGGCAGGCGGCAA
AGATCTGCAACAACATGCTGTTAGCTATTAGTATGATTGGAACTGCTGAAGCTATGAATCTTGG
AATCAGGTTAGGGCTTGACCCAAAACTACTGGCTAAAATCCTAAATATGAGCTCAGGACGGTGT
TGGTCAAGTGACACTTATAATCCTGTACCTGGAGTGATGGATGGCGTTCCCTCGGCTAATAACT
ATCAGGGTGGATTTGGAACAACACTCATGGCTAAGGATCTGGGATTGGCACAAGACTCTGCTAC
CAGCACAAAGAGCCCAATCCTTCTTGGCAGTCTGGCCCATCAGATCTACAGGATGATGTGTGCA
AAGGGCTACTCAAAGAAAGACTTCTCATCCGTGTTCCAGTTCCTACGAGAGGAGGAGACCTTCT
GAGTGTGCCCTTTGGCCATGGACACTGTTGGGAACCAAACTCTGTCTTGGAGCCTCCTTTTAGC
TCACTCCACAAGTAAATGGATTTAATCAAAGGTCACCTATCTGCTTTTGATTGTCTAGGTCACA
GTAATCCCTAGGATTTTTCACCCATTTTTAACCGCTTATTCTTTTTGTCTTTTTAACAAACATA
TTATCCGAATTTTTTTTCTGCAAGCCACTGATAGTCTCTGCTAACTAGCTTAATTGACCTTTTT
ACAAAGTTTGATCCCCAAGCATCCTCAACTAAATCATTGAATACTTCAATCAGGATATTATCTG
CTTTACTTTACAAATAAAACCAAATCTTTTGTCAACAGGATGAAACCCATCTTAAAGGAAAGAA
AAGGAATTGGTGTGAAGAGAGAAGTTAGAGAAGGGAAATGCAGTGAATTACTATCTGTGTCCAT
CAGGAAGTTTGTCCTGTTAACCAAATGGTTACTGCACTACCAGGGTTACTGGTTTATTTTCCAG
GGAGCAGATAAAGCAGGAGAACTGTTGCTGCATGTTTTCTATTTGGACTCCGTCACAATATGGT
AGGATATCCCTCACCAACTCCCGACACTCAGCAGACTTGTTTTTATATTTTTTTCTTTCTTGTA
CATTCTTACTACGTATTTTTTGACTTAAGAATGACATCTTTAGACGCATTTCAGAGCCAATGAT
GATATTTGCTTTAGATAATTATTATATTATTATAAATATAGCCATATTATTTTGAATTCAAATA
AATTTCTATACTGGTAATA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003807946	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000039742.1

RefSeq Acc Id:

XP_003807946 ⟸ XM_003807898

- UniProtKB:

A0A2R9CNE8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAASLRLLGAASGLRYWSRRLRPAAGSFAAVCSRSVASKTPVGFIGLGNMGNPMAKNLMKHGYP
LIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGILKKVKKGSL
LIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVEDEFAAAQELLGCM
GSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGLDPKLLAKILNMSSGRCWSSDT
YNPVPGVMDGVPSANNYQGGFGTTLMAKDLGLAQDSATSTKSPILLGSLAHQIYRMMCAKGYSK
KDFSSVFQFLREEETF

hide sequence

Ensembl Acc Id:

ENSPPAP00000039742 ⟸ ENSPPAT00000062654

Protein Domains

3-hydroxyisobutyrate dehydrogenase-like NAD-binding 6-phosphogluconate dehydrogenase NADP-binding

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000042554	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000062654.1	UniProtKB/TrEMBL
Gene3D-CATH	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2	UniProtKB/TrEMBL
	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	3-OH-isobutyrate_DH-rel_CS	UniProtKB/TrEMBL
	6-PGluconate_DH-like_C_sf	UniProtKB/TrEMBL
	6PGD_dom2	UniProtKB/TrEMBL
	6PGDH_NADP-bd	UniProtKB/TrEMBL
	HIBADH	UniProtKB/TrEMBL
	HIBADH-related	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	NADP-bd	UniProtKB/TrEMBL
KEGG Report	pps:100975479	UniProtKB/TrEMBL
NCBI Gene	HIBADH	ENTREZGENE
PANTHER	3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL	UniProtKB/TrEMBL
	3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED	UniProtKB/TrEMBL
Pfam	NAD_binding_11	UniProtKB/TrEMBL
	NAD_binding_2	UniProtKB/TrEMBL
PIRSF	HIBADH	UniProtKB/TrEMBL
PROSITE	3_HYDROXYISOBUT_DH	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48179	UniProtKB/TrEMBL
	SSF51735	UniProtKB/TrEMBL
UniProt	A0A2R9CNE8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB