TAS2R38 (taste 2 receptor member 38)

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Gene: TAS2R38 (taste 2 receptor member 38) Pan paniscus

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Symbol:

TAS2R38

Name:

taste 2 receptor member 38

RGD ID:

11701175

Description:

ENCODES a protein that exhibits bitter taste receptor activity (inferred); G protein-coupled receptor activity (inferred); INVOLVED IN detection of chemical stimulus involved in sensory perception of bitter taste (inferred); G protein-coupled receptor signaling pathway (inferred); sensory perception of taste (inferred); ASSOCIATED WITH alcohol use disorder (ortholog); Hereditary Pancreatitis (ortholog); RASopathy (ortholog); FOUND IN plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

bitter taste receptor TAS2R38; TAS2R; taste receptor T2R38; taste receptor type 2 member 38

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	178,753,452 - 178,754,594 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	30,763,707 - 30,764,849 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	133,896,405 - 133,897,535 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	146,365,476 - 146,366,606 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	146,365,527 - 146,366,528 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcohol use disorder (ISO)

Hereditary Pancreatitis (ISO)

RASopathy (ISO)

Sengers syndrome (ISO)

Thiourea Tasting (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

detection of chemical stimulus involved in sensory perception of bitter taste (IEA)

G protein-coupled receptor signaling pathway (IEA)

sensory perception of taste (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IEA,ISO)

Molecular Function

bitter taste receptor activity (IEA)

G protein-coupled receptor activity (IEA)

References

Additional References at PubMed

PMID:15466715	PMID:15496549	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

TAS2R38
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	178,753,452 - 178,754,594 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	30,763,707 - 30,764,849 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	133,896,405 - 133,897,535 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	146,365,476 - 146,366,606 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	146,365,527 - 146,366,528 (-)	Ensembl	panpan1.1		panPan2

TAS2R38
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	141,972,631 - 141,973,773 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	141,972,631 - 141,973,773 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	141,672,431 - 141,673,573 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	141,318,900 - 141,320,042 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	141,125,671 - 141,126,673	NCBI
Celera	7	136,393,776 - 136,394,918 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI
HuRef	7	135,968,803 - 135,969,945 (-)	NCBI		HuRef
CHM1_1	7	141,606,660 - 141,607,802 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	143,288,364 - 143,289,506 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	141,010,626 - 141,011,768 (-)	NCBI

Tas2r138
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	40,589,249 - 40,590,244 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	40,589,249 - 40,590,244 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	40,612,315 - 40,613,310 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	40,612,315 - 40,613,310 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	40,562,314 - 40,563,309 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	40,541,922 - 40,542,917 (-)	NCBI		MGSCv36	mm8
Celera	6	40,599,002 - 40,599,998 (-)	NCBI		Celera
Cytogenetic Map	6	B1	NCBI
cM Map	6	18.82	NCBI

Tas2r138
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	70,395,042 - 70,396,037 (-)	NCBI		GRCr8
mRatBN7.2	4	69,428,344 - 69,429,339 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	69,428,344 - 69,429,339 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	74,356,622 - 74,357,617 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	70,277,771 - 70,278,766 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	68,685,381 - 68,686,376 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	68,831,221 - 68,832,216 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	68,831,221 - 68,832,216 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	133,618,347 - 133,619,342 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	68,196,172 - 68,197,167 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	64,418,515 - 64,419,480 (-)	NCBI		Celera
Cytogenetic Map	4	q23	NCBI

Tas2r38
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955494	1,659,692 - 1,662,712 (+)	NCBI	ChiLan1.0	ChiLan1.0

TAS2R38
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	7,224,077 - 7,225,027 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	7,224,023 - 7,225,027 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	8,083,355 - 8,084,305 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	7,145,620 - 7,146,570 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	7,145,566 - 7,146,570 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	7,099,027 - 7,099,976 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	6,941,424 - 6,942,374 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	7,009,125 - 7,010,075 (+)	NCBI		UU_Cfam_GSD_1.0

Tas2r38
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	13,460,239 - 13,462,689 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936592	5,757,282 - 5,758,182 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TAS2R38
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	18	7,982,188 - 7,983,921 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	8,357,518 - 8,358,525 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TAS2R38
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	110,671,289 - 110,674,330 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	110,672,521 - 110,673,519 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666072	7,359,669 - 7,360,843 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tas2r38
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624765	21,906,697 - 21,907,716 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003813370	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY566401	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY677143	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY724867	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JARIFH020000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JQ272200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000021403 ⟹ ENSPPAP00000004675

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	146,365,527 - 146,366,528 (-)	Ensembl

RefSeq Acc Id:

XM_003813370 ⟹ XP_003813418

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	178,753,452 - 178,754,594 (-)	NCBI
NHGRI_mPanPan1	7	30,763,707 - 30,764,849 (-)	NCBI
Mhudiblu_PPA_v0	7	133,896,405 - 133,897,535 (-)	NCBI
PanPan1.1	7	146,365,476 - 146,366,606 (-)	NCBI

Sequence:

show sequence

TGCACTGGGTGGCAACTAGGTCTTTAGATTAGCCAACTAGAGAAGAGAAGTAGAATAGCCAATT
AGAGAAGTGACATCATGTTGACTCTAACTCGCATCCACACTGTGTCCTATGAAGTCAGGAGTAC
ATTTCTGTTCATTTCAGTCCTGGAGTTCGCAGTGGGGTTTCTGACCAATGCCTTCGTTTTCTTG
GTGAATTTTTGGGATGTAGTGAAGAGGCAGCCACTGAGCAACAGTGATTGTGTGCTGCTGTGTC
TCAGCATCAGCCGGCTTTTCCTGCATGGACTGCTGTTCCTGAGTGCTATCCAGCTTACCCACTT
CCAGAAGTTGAGTGAACCACTGAACCACAGCTACCAAGCCATCAACATGCTATGGATGATTGCA
AACCAAGCCAACCTCTGGCTTGCGGCCTGCCTCAGCCTGCTTTACTGCTCCAAGCTCATCCGTT
TCTCTCACACCTTCCTGATCTGCTTGGCAAGCTGGGTCTCCAGGAAGATCTCCCAGATGCTCCT
GGGTATTATTCTTTGCTCCTGCATCTGCACTGTCCTCTGTGTTTGGTGCTTTTTTAGCAGACCT
CACTTCACAGTCACAACTGTGCTATTCATGAATAACAATACAAGGCTCAACTGGCAGATTAAAG
ATCTCAACTTATTTTATTCCTTTCTCTTCTGCTATCTGTGGTCTGTGCCTCCTTTCCTATTGTT
TCTGGTTTCTTCTGGGATGCTGACTGTCTCCCTGGGAAGGCACATGAGGACAATGAAGGTCTAT
ACCAGAGACTCTCGTGACCCCAGCCTGGAGGCCCACATTAAGGCCCTCAAGTCTCTTGTCTCCT
TTTTCTGCTTCTTTGTGATATCATCCTGTGCTGCCTTCATCTCTGTGCCCCTACTGATTCTGTG
GCGTGACAAAATAGGGGTGATGGTTTGTGTTGGGATAATGGCAGCTTGTCCCTCTGGGCATGCA
GCTGTCCTGATCTCAGGCAATGCCAAGTTGAGGAGAGCTGTGACGACCATTCTGCTCTGGGCTC
AGAGCAGCCTGAAGGTAAGAGCCGACCACAAGGCAGATTCCCGGACACTGTGCTGAGAATGGAC
ATGAAATGAGCTCTTCATTAATACGCCTGTGAGTCTTCATAAA

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Protein Sequences


Protein RefSeqs	XP_003813418	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAS67621	(Get FASTA)	NCBI Sequence Viewer
	AAU21090	(Get FASTA)	NCBI Sequence Viewer
	AAV28571	(Get FASTA)	NCBI Sequence Viewer
	AFH77564	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000004675
	ENSPPAP00000004675.1
GenBank Protein	Q697L6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_003813418 ⟸ XM_003813370

- UniProtKB:

Q646C9 (UniProtKB/Swiss-Prot), Q697L6 (UniProtKB/Swiss-Prot), I0CKB7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLTLTRIHTVSYEVRSTFLFISVLEFAVGFLTNAFVFLVNFWDVVKRQPLSNSDCVLLCLSISR
LFLHGLLFLSAIQLTHFQKLSEPLNHSYQAINMLWMIANQANLWLAACLSLLYCSKLIRFSHTF
LICLASWVSRKISQMLLGIILCSCICTVLCVWCFFSRPHFTVTTVLFMNNNTRLNWQIKDLNLF
YSFLFCYLWSVPPFLLFLVSSGMLTVSLGRHMRTMKVYTRDSRDPSLEAHIKALKSLVSFFCFF
VISSCAAFISVPLLILWRDKIGVMVCVGIMAACPSGHAAVLISGNAKLRRAVTTILLWAQSSLK
VRADHKADSRTLC

hide sequence

Ensembl Acc Id:

ENSPPAP00000004675 ⟸ ENSPPAT00000021403

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000019525	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSPPAT00000021403.1	UniProtKB/Swiss-Prot
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	TAS2R	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TAS2R38	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	pps:100992496	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	TAS2R38	ENTREZGENE
PANTHER	PTHR11394:SF52	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TASTE RECEPTOR TYPE 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	TAS2R	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	I0CKB7	ENTREZGENE, UniProtKB/TrEMBL
	Q646C9	ENTREZGENE
	Q697L6	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q646C9	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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