FRMD5 (FERM domain containing 5) - Rat Genome Database

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Gene: FRMD5 (FERM domain containing 5) Pan paniscus
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Symbol: FRMD5
Name: FERM domain containing 5
RGD ID: 11695622
Description: ENCODES a protein that exhibits cytoskeletal protein binding (inferred); integrin binding (inferred); protein kinase binding (inferred); INVOLVED IN actomyosin structure organization (inferred); negative regulation of cell motility (inferred); positive regulation of cell adhesion (inferred); ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal recessive nonsyndromic deafness 16 (ortholog); Bloom syndrome (ortholog); FOUND IN adherens junction (inferred); cytoskeleton (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: FERM domain-containing protein 5; LOC129393948; uncharacterized LOC129393948
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21633,122,498 - 33,539,936 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11537,284,225 - 37,614,938 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01522,830,850 - 23,161,693 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11540,920,868 - 41,251,759 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1540,919,053 - 41,250,981 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
FRMD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21633,122,498 - 33,539,936 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11537,284,225 - 37,614,938 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01522,830,850 - 23,161,693 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11540,920,868 - 41,251,759 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1540,919,053 - 41,250,981 (-)Ensemblpanpan1.1panPan2
FRMD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381543,870,764 - 44,199,473 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1543,870,761 - 44,195,271 (-)EnsemblGRCh38hg38GRCh38
GRCh371544,162,962 - 44,487,469 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361541,953,022 - 42,274,721 (-)NCBINCBI36Build 36hg18NCBI36
Celera1521,055,188 - 21,376,921 (-)NCBICelera
Cytogenetic Map15q15.3NCBI
HuRef1520,988,457 - 21,310,775 (-)NCBIHuRef
CHM1_11544,283,981 - 44,605,691 (-)NCBICHM1_1
T2T-CHM13v2.01541,678,124 - 42,006,910 (-)NCBIT2T-CHM13v2.0
Frmd5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392121,376,010 - 121,637,580 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2121,376,010 - 121,637,568 (-)EnsemblGRCm39 Ensembl
GRCm382121,545,529 - 121,807,087 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2121,545,529 - 121,807,087 (-)EnsemblGRCm38mm10GRCm38
MGSCv372121,371,265 - 121,632,793 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362121,236,970 - 121,498,455 (-)NCBIMGSCv36mm8
Celera2122,692,965 - 122,957,219 (-)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.42NCBI
Frmd5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83128,945,812 - 129,217,134 (-)NCBIGRCr8
mRatBN7.23108,492,099 - 108,763,715 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3108,474,562 - 108,763,498 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.03113,480,780 - 113,755,286 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3113,483,269 - 113,525,864 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03120,021,152 - 120,295,167 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43108,323,041 - 108,591,163 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3107,393,126 - 107,664,345 (-)NCBICelera
Cytogenetic Map3q35NCBI
Frmd5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541610,338,061 - 10,682,810 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541610,338,061 - 10,683,069 (-)NCBIChiLan1.0ChiLan1.0
FRMD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13010,611,986 - 10,923,444 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3010,614,406 - 10,923,261 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3010,670,228 - 10,980,961 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03010,748,561 - 11,060,094 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3010,748,564 - 11,060,055 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13010,657,550 - 10,967,594 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03010,779,973 - 11,091,358 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03010,899,408 - 11,210,322 (-)NCBIUU_Cfam_GSD_1.0
Frmd5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864089,077,981 - 89,385,165 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364716,928,398 - 7,232,765 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364716,926,044 - 7,233,006 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FRMD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1127,317,701 - 127,650,665 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11127,317,660 - 127,653,112 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21142,444,648 - 142,478,602 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FRMD5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12638,847,310 - 39,179,487 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2639,119,525 - 39,170,954 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048101,819,536 - 102,191,869 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Frmd5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480410,906,958 - 11,239,995 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480410,906,085 - 11,240,249 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000043672   ⟹   ENSPPAP00000020874
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1540,919,053 - 40,969,725 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000043714   ⟹   ENSPPAP00000020915
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1540,923,247 - 41,250,981 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000043734   ⟹   ENSPPAP00000020935
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1540,923,985 - 41,250,981 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000043744   ⟹   ENSPPAP00000020945
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1540,923,985 - 40,978,825 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000043748   ⟹   ENSPPAP00000020949
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1540,923,985 - 40,952,426 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000043755   ⟹   ENSPPAP00000020956
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1540,923,985 - 40,943,500 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000043760   ⟹   ENSPPAP00000020961
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1540,923,985 - 40,929,738 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000043766   ⟹   ENSPPAP00000020967
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1540,923,992 - 40,969,725 (-)Ensembl
RefSeq Acc Id: XM_003814960   ⟹   XP_003815008
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21633,122,498 - 33,453,429 (-)NCBI
NHGRI_mPanPan11537,284,225 - 37,614,938 (-)NCBI
Mhudiblu_PPA_v01522,830,850 - 23,161,693 (-)NCBI
PanPan1.11540,920,868 - 41,251,759 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008967835   ⟹   XP_008966083
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21633,122,498 - 33,453,411 (-)NCBI
NHGRI_mPanPan11537,284,225 - 37,614,920 (-)NCBI
Mhudiblu_PPA_v01522,830,850 - 23,161,664 (-)NCBI
PanPan1.11540,920,868 - 41,251,759 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008967836   ⟹   XP_008966084
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21633,122,498 - 33,453,413 (-)NCBI
NHGRI_mPanPan11537,284,225 - 37,614,922 (-)NCBI
Mhudiblu_PPA_v01522,830,850 - 23,161,693 (-)NCBI
PanPan1.11540,920,868 - 41,251,759 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008967837   ⟹   XP_008966085
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21633,122,498 - 33,453,417 (-)NCBI
NHGRI_mPanPan11537,284,225 - 37,614,926 (-)NCBI
Mhudiblu_PPA_v01522,830,850 - 23,161,693 (-)NCBI
PanPan1.11540,920,868 - 41,251,759 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034938667   ⟹   XP_034794558
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21633,122,498 - 33,453,406 (-)NCBI
NHGRI_mPanPan11537,284,225 - 37,614,917 (-)NCBI
Mhudiblu_PPA_v01522,830,850 - 23,161,664 (-)NCBI
RefSeq Acc Id: XM_034938668   ⟹   XP_034794559
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21633,122,498 - 33,453,409 (-)NCBI
NHGRI_mPanPan11537,284,225 - 37,614,919 (-)NCBI
Mhudiblu_PPA_v01522,830,850 - 23,161,667 (-)NCBI
RefSeq Acc Id: XM_034938669   ⟹   XP_034794560
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21633,122,498 - 33,453,409 (-)NCBI
NHGRI_mPanPan11537,284,225 - 37,614,919 (-)NCBI
Mhudiblu_PPA_v01522,830,850 - 23,161,667 (-)NCBI
RefSeq Acc Id: XM_034938670   ⟹   XP_034794561
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21633,122,498 - 33,453,408 (-)NCBI
NHGRI_mPanPan11537,284,225 - 37,614,918 (-)NCBI
Mhudiblu_PPA_v01522,830,850 - 23,161,666 (-)NCBI
RefSeq Acc Id: XM_063596611   ⟹   XP_063452681
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21633,122,498 - 33,539,936 (-)NCBI
RefSeq Acc Id: XM_063596612   ⟹   XP_063452682
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21633,122,498 - 33,157,513 (-)NCBI
RefSeq Acc Id: XP_008966084   ⟸   XM_008967836
- Peptide Label: isoform X7
- UniProtKB: A0A2R9AYM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008966083   ⟸   XM_008967835
- Peptide Label: isoform X6
- UniProtKB: A0A2R9AYJ8 (UniProtKB/TrEMBL),   A0A2R9AYM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008966085   ⟸   XM_008967837
- Peptide Label: isoform X9
- UniProtKB: A0A2R9AYM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003815008   ⟸   XM_003814960
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AYL7 (UniProtKB/TrEMBL),   A0A2R9AYM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034794560   ⟸   XM_034938669
- Peptide Label: isoform X4
- UniProtKB: A0A2R9AYM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034794559   ⟸   XM_034938668
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AYM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034794561   ⟸   XM_034938670
- Peptide Label: isoform X5
- UniProtKB: A0A2R9AYM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034794558   ⟸   XM_034938667
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AYM9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000020874   ⟸   ENSPPAT00000043672
Ensembl Acc Id: ENSPPAP00000020915   ⟸   ENSPPAT00000043714
Ensembl Acc Id: ENSPPAP00000020935   ⟸   ENSPPAT00000043734
Ensembl Acc Id: ENSPPAP00000020945   ⟸   ENSPPAT00000043744
Ensembl Acc Id: ENSPPAP00000020949   ⟸   ENSPPAT00000043748
Ensembl Acc Id: ENSPPAP00000020956   ⟸   ENSPPAT00000043755
Ensembl Acc Id: ENSPPAP00000020967   ⟸   ENSPPAT00000043766
Ensembl Acc Id: ENSPPAP00000020961   ⟸   ENSPPAT00000043760
RefSeq Acc Id: XP_063452681   ⟸   XM_063596611
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063452682   ⟸   XM_063596612
- Peptide Label: isoform X10
Protein Domains
FERM   FERM adjacent   FERM C-terminal PH-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000033588 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000043672.1 UniProtKB/TrEMBL
  ENSPPAT00000043714.1 UniProtKB/TrEMBL
  ENSPPAT00000043734.1 UniProtKB/TrEMBL
  ENSPPAT00000043744.1 UniProtKB/TrEMBL
  ENSPPAT00000043748.1 UniProtKB/TrEMBL
  ENSPPAT00000043755.1 UniProtKB/TrEMBL
  ENSPPAT00000043760.1 UniProtKB/TrEMBL
  ENSPPAT00000043766.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  Ez/rad/moesin-like UniProtKB/TrEMBL
  FERM-adjacent UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_CS UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
KEGG Report pps:100990252 UniProtKB/TrEMBL
NCBI Gene FRMD5 ENTREZGENE
PANTHER 4.1 G PROTEIN UniProtKB/TrEMBL
  FERM DOMAIN-CONTAINING PROTEIN 5 UniProtKB/TrEMBL
Pfam FERM_C UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  PF08736 UniProtKB/TrEMBL
PRINTS BAND41 UniProtKB/TrEMBL
  ERMFAMILY UniProtKB/TrEMBL
PROSITE FERM_1 UniProtKB/TrEMBL
  FERM_3 UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
  SM01195 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47031 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A2R9AUG6_PANPA UniProtKB/TrEMBL
  A0A2R9AUH2_PANPA UniProtKB/TrEMBL
  A0A2R9AUI0_PANPA UniProtKB/TrEMBL
  A0A2R9AYJ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AYL7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AYM9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B0G0_PANPA UniProtKB/TrEMBL
  A0A2R9B0N2_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-03-14 FRMD5  FERM domain containing 5  LOC129393948  uncharacterized LOC129393948  Data Merged 737654 PROVISIONAL