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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1605432
Species: Homo sapiens
RGD Object: Gene
Symbol: RAC1
Name: Rac family small GTPase 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RAC1increases activityISORac1 (Rattus norvegicus)6480464CTDStreptozocin results in increased activity of RAC1 proteinPMID:17589825
RAC1multiple interactionsISORac1 (Mus musculus)6480464CTDAtorvastatin inhibits the reaction [Streptozocin results in increased activity of and results in increased localization of RAC1 protein]; Streptozocin results in increased activity of and results in increased localization of RAC1 proteinPMID:17279352
RAC1multiple interactionsISORac1 (Rattus norvegicus)6480464CTDAtorvastatin inhibits the reaction [Streptozocin results in increased activity of RAC1 protein]PMID:17589825
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