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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:9062
Term: scutellarein
Definition: Flavone substituted with hydroxy groups at C-4', -5, -6 and -7.
Chemical ID: MESH:C458179
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1affects metabolic processingISOCYP1A1 (Homo sapiens)6480464CTDCYP1A1 protein affects the metabolism of scutellareinPMID:19666078
Cyp1a1decreases activityISOCYP1A1 (Homo sapiens)6480464CTDscutellarein results in decreased activity of CYP1A1 proteinPMID:21482471
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[CYP1A1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolinPMID:19666078
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