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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10823
Species: Mus musculus
RGD Object: Gene
Symbol: Jak2
Name: Janus kinase 2
Acc ID: CHEBI:85078
Term: dapagliflozin
Definition: A C-glycosyl comprising beta-D-glucose in which the anomeric hydroxy group is replaced by a 4-chloro-3-(4-ethoxybenzyl)phenyl group. Used (in the form of its propanediol monohydrate) to improve glycemic control, along with diet and exercise, in adults with type 2 diabetes.
Chemical ID: MESH:C529054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jak2multiple interactionsISOJak2 (Rattus norvegicus)6480464CTDdapagliflozin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of JAK2 protein]PMID:34391751
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