GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | TFR2 | affects response to substance | EXP | | 6480464 | CTD | TFR2 protein affects the susceptibility to Iron | PMID:16893896 | TFR2 | multiple interactions | EXP | | 6480464 | CTD | [HFE protein binds to TFR2 protein] which affects the susceptibility to Iron | PMID:16893896 | TFR2 | affects metabolic processing | ISO | Tfr2 (Mus musculus) | 6480464 | CTD | TFR2 protein affects the metabolism of Iron | PMID:17194590 PMID:17241880 | TFR2 | decreases expression | ISO | Tfr2 (Rattus norvegicus) | 6480464 | CTD | Iron deficiency results in decreased expression of TFR2 protein | PMID:20164366 PMID:22457245 | TFR2 | increases uptake | ISO | Tfr2 (Mus musculus) | 6480464 | CTD | TFR2 protein mutant form results in increased uptake of Iron | PMID:16935854 | TFR2 | multiple interactions | ISO | Tfr2 (Mus musculus) | 6480464 | CTD | [HBB-B1 gene mutant form results in increased abundance of Iron] which results in decreased expression of TFR2 mRNA; [HBB-B2 gene mutant form results in increased abundance of Iron] which results in decreased expression of TFR2 mRNA; [HFE gene mutant form co-treated with TFR2 gene mutant form] results in increased abundance of Iron; Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of TFR2 protein] | PMID:17018382 PMID:19061943 PMID:22383097 | | ||||||||||||||||||||||
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