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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352582
Species: Homo sapiens
RGD Object: Gene
Symbol: IL6
Name: interleukin 6
Acc ID: CHEBI:78510
Term: dorsomorphin
Definition: A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.
Chemical ID: MESH:C516138
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL6multiple interactionsEXP 6480464CTD[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL6 mRNA; [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL6 mRNA; dorsomorphin inhibits the reaction [gastrodin inhibits the reaction [Oleic Acid results in increased expression of IL6 mRNA]]; dorsomorphin inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]PMID:25633564 PMID:26634892 PMID:27188386
IL6multiple interactionsISOIl6 (Mus musculus)6480464CTDdorsomorphin inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; dorsomorphin inhibits the reaction [AICA ribonucleotide results in decreased expression of IL6 mRNA]; dorsomorphin inhibits the reaction [MAF1 protein inhibits the reaction [Sevoflurane results in increased secretion of IL6 protein]]; dorsomorphin inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]; dorsomorphin inhibits the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL6 protein]]PMID:24465016 PMID:24756886 PMID:29859833 PMID:35430185
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