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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dorsomorphin
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Accession:CHEBI:78510 term browser browse the term
Definition:A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.
Synonyms:exact_synonym: 6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
 related_synonym: Formula=C24H25N5O;   InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2;   InChIKey=XHBVYDAKJHETMP-UHFFFAOYSA-N;   SMILES=C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1;   compound C
 alt_id: MESH:C516138
 xref: CAS:866405-64-3;   DrugBank:DB08597;   LINCS:LSM-3207
 xref_mesh: MESH:C516138
 xref: PDBeChem:TAK;   PMID:18026094;   PMID:18682835;   PMID:19996563;   PMID:20691279;   PMID:21384475;   PMID:21543851;   PMID:21988724;   PMID:23526253;   PMID:23936500;   PMID:24280125;   PMID:24396733;   Reaxys:11725482


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Path 1
Term Annotations click to browse term
  CHEBI ontology 24386
    role 24296
      biological role 24263
        pharmacological role 21140
          antagonist 17307
            bone morphogenetic protein receptor antagonist 6087
              dorsomorphin 6087
Path 2
Term Annotations click to browse term
  CHEBI ontology 24386
    subatomic particle 24343
      composite particle 24343
        hadron 24343
          baryon 24343
            nucleon 24343
              atomic nucleus 24343
                atom 24343
                  main group element atom 24190
                    p-block element atom 24190
                      carbon group element atom 23972
                        carbon atom 23933
                          organic molecular entity 23933
                            organic molecule 23815
                              organic cyclic compound 23100
                                organic heterocyclic compound 21235
                                  organic heteropolycyclic compound 20275
                                    organic heterobicyclic compound 17841
                                      pyrazolopyrimidine 6126
                                        dorsomorphin 6087
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