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Accession:CHEBI:78510 term browser browse the term
Definition:A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC and a selective inhibitor of bone morphogenetic protein (BMP) signaling.
Synonyms:exact_synonym: 6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
 related_synonym: Formula=C24H25N5O;   InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2;   InChIKey=XHBVYDAKJHETMP-UHFFFAOYSA-N;   SMILES=C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1;   compound C
 alt_id: MESH:C516138
 xref: CAS:866405-64-3 "ChemIDplus";   DrugBank:DB08597;   LINCS:LSM-3207
 xref_mesh: MESH:C516138
 xref: PDBeChem:TAK;   PMID:18026094 "Europe PMC";   PMID:18682835 "Europe PMC";   PMID:19996563 "Europe PMC";   PMID:20691279 "Europe PMC";   PMID:21384475 "Europe PMC";   PMID:21543851 "Europe PMC";   PMID:21988724 "Europe PMC";   PMID:23526253 "Europe PMC";   PMID:23936500 "Europe PMC";   PMID:24280125 "Europe PMC";   PMID:24396733 "Europe PMC";   Reaxys:11725482 "Reaxys"

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  CHEBI ontology 23680
    role 23568
      biological role 23529
        pharmacological role 20776
          antagonist 16595
            bone morphogenetic protein receptor antagonist 6081
              dorsomorphin 6081
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  CHEBI ontology 23680
    subatomic particle 23627
      composite particle 23627
        hadron 23627
          baryon 23627
            nucleon 23627
              atomic nucleus 23627
                atom 23627
                  main group element atom 23444
                    p-block element atom 23444
                      carbon group element atom 23143
                        carbon atom 23119
                          organic molecular entity 23119
                            organic molecule 22975
                              organic cyclic compound 21941
                                organic heterocyclic compound 20577
                                  organic heteropolycyclic compound 19648
                                    organic heterobicyclic compound 16686
                                      pyrazolopyrimidine 6118
                                        dorsomorphin 6081
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.