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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735742
Species: Mus musculus
RGD Object: Gene
Symbol: Ccnb1
Name: cyclin B1
Acc ID: CHEBI:78492
Term: diallyl trisulfide
Definition: An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity
Chemical ID: MESH:C042577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnb1affects localizationISOCCNB1 (Homo sapiens)6480464CTDdiallyl trisulfide affects the localization of CCNB1 proteinPMID:20143254
Ccnb1decreases expressionISOCCNB1 (Homo sapiens)6480464CTDdiallyl trisulfide results in decreased expression of CCNB1 mRNA; diallyl trisulfide results in decreased expression of CCNB1 proteinPMID:34995734
Ccnb1increases expressionISOCCNB1 (Homo sapiens)6480464CTDdiallyl trisulfide results in increased expression of CCNB1 proteinPMID:19823037 PMID:24415872
Ccnb1multiple interactionsISOCCNB1 (Homo sapiens)6480464CTDdiallyl trisulfide promotes the reaction [CDK1 protein binds to CCNB1 protein]; diallyl trisulfide results in decreased activity of [CDK1 protein binds to CCNB1 protein]PMID:20143254
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