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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733473
Species: Homo sapiens
RGD Object: Gene
Symbol: IRS1
Name: insulin receptor substrate 1
Acc ID: CHEBI:77156
Term: gypenoside LXXV
Definition: A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 20 has been converted to the corresponding beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.
Chemical ID: MESH:C000719168
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IRS1decreases phosphorylationISOIrs1 (Mus musculus)6480464CTDgypenoside LXXV results in decreased phosphorylation of IRS1 proteinPMID:36325883
IRS1multiple interactionsISOIrs1 (Mus musculus)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of IRS1 protein]; gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of IRS1 proteinPMID:35192202
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