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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619570
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK3
Name: mitogen-activated protein kinase 3
Acc ID: CHEBI:77149
Term: notoginsenoside R1
Definition: A ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position.
Chemical ID: MESH:C072936
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK3multiple interactionsEXP 6480464CTDnotoginsenoside R1 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]PMID:16458614 PMID:16632126
MAPK3increases phosphorylationISOMapk3 (Rattus norvegicus)6480464CTDnotoginsenoside R1 results in increased phosphorylation of MAPK3 proteinPMID:24437944
MAPK3multiple interactionsISOMapk3 (Rattus norvegicus)6480464CTDfulvestrant inhibits the reaction [notoginsenoside R1 results in increased phosphorylation of MAPK3 protein]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK3 mRNA]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK3 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK3 protein]PMID:24437944 PMID:24975829 PMID:25004876
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