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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1549988
Species: Mus musculus
RGD Object: Gene
Symbol: Tlr9
Name: toll-like receptor 9
Acc ID: CHEBI:76326
Term: N-nitrosomorpholine
Definition: A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco.
Chemical ID: MESH:C002741
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr9multiple interactionsISOTlr9 (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of TLR9 protein; Chloroquine inhibits the reaction [[Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of TLR9 protein]PMID:24990399
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