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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308542
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: CHEBI:74856
Term: antimony trichloride
Definition: An inorganic chloride salt with formula SbCl3. It is used as a reagent for detecting vitamin A and related carotenoids, reacting with the carotenoid to form a blue complex that can be measured by colorimetry (the Carr-Price test). Solutions of antimony trichloride were formerly used for dissolving and removing horn stubs from calves and goats.
Chemical ID: MESH:C054672
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1decreases expressionISORGD:13183746480464CTDantimony trichloride results in decreased expression of SIRT1 mRNA, antimony trichloride results in decreased expression of SIRT1 protein

PMID:30055241
Sirt1multiple interactionsISORGD:13183746480464CTDAcetylcysteine inhibits the reaction [antimony trichloride results in decreased expression of SIRT1 mRNA], Acetylcysteine inhibits the reaction [antimony trichloride results in decreased expression of SIRT1 protein], Cycloheximide promotes the reaction [antimony trichloride results in decreased expression of SIRT1 protein], Dactinomycin affects the reaction [antimony trichloride results in decreased expression of SIRT1 mRNA], U 0126 inhibits the reaction [antimony trichloride results in decreased expression of SIRT1 protein]

PMID:30055241
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.