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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10226
Species: Mus musculus
RGD Object: Gene
Symbol: Bax
Name: BCL2-associated X protein
Acc ID: CHEBI:73158
Term: sirtinol
Definition: A benzamide obtained by formal condensation of the carboxy group of 2-{[(2-hydroxy-1-naphthyl)methylene]amino}benzoic acid with the amino group of 1-phenylethylamine.
Chemical ID: MESH:C439060
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsEXP 6480464CTDsirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]PMID:25665036 PMID:26450947
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDsirtinol inhibits the reaction [rhodioloside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; sirtinol promotes the reaction [cudraflavone B results in increased expression of BAX protein]PMID:23881456 PMID:28851138
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