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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3540
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rb1
Name: RB transcriptional corepressor 1
Acc ID: CHEBI:6413
Term: letrozole
Definition: A triazole that has formula C17H11N5.
Chemical ID: MESH:C067431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rb1multiple interactionsISORB1 (Homo sapiens)6480464CTD[letrozole co-treated with Everolimus] results in decreased phosphorylation of and affects the activity of RB1 protein; [Sirolimus co-treated with letrozole] results in decreased expression of RB1 protein; [sorafenib co-treated with letrozole] results in decreased expression of RB1 protein; letrozole results in decreased phosphorylation of and affects the activity of RB1 proteinPMID:16033851 PMID:20054642
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