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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620089
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ocln
Name: occludin
Acc ID: CHEBI:63949
Term: 2,3-bis(4-hydroxyphenyl)propionitrile
Definition: A nitrile that is acetonitrile in which one of the hydrogens is replaced by a 4-hydroxyphenyl group while a second hydrogen is replaced by a 4-hydroxybenzyl group. It is a specific agonist for estrogen receptor beta (ERbeta).
Chemical ID: MESH:C486182
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Oclnincreases expressionISOOCLN (Homo sapiens)6480464CTD2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of OCLN mRNA; 2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of OCLN proteinPMID:19433574
Oclnmultiple interactionsISOOCLN (Homo sapiens)6480464CTDFulvestrant inhibits the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of OCLN mRNA]; Fulvestrant inhibits the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of OCLN protein]PMID:19433574
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