Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:5292
Term: geldanamycin
Definition: An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.
Chemical ID: MESH:C001277
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Aincreases expressionEXP 6480464CTDgeldanamycin results in increased expression of HSPA1A mRNA; geldanamycin results in increased expression of HSPA1A proteinPMID:11448926 PMID:25477506
HSPA1Aincreases expressionISOHspa1a (Rattus norvegicus)6480464CTDgeldanamycin results in increased expression of HSPA1A mRNA; geldanamycin results in increased expression of HSPA1A proteinPMID:19723345
HSPA1Amultiple interactionsISOHspa1a (Rattus norvegicus)6480464CTD[geldanamycin results in increased expression of HSPA1A protein] which results in decreased susceptibility to GentamicinsPMID:19723345
Go Back to source page   Continue to Ontology report