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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70494
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tert
Name: telomerase reverse transcriptase
Acc ID: CHEBI:52221
Term: isothiocyanate
Definition: An organosulfur compound with the general formula R-N=C=S.
Chemical ID: MESH:D017879
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tertdecreases activityISOTERT (Homo sapiens)6480464CTDIsothiocyanates results in decreased activity of TERT proteinPMID:23382840
Tertdecreases expressionISOTERT (Homo sapiens)6480464CTDIsothiocyanates results in decreased expression of TERT mRNAPMID:23382840
Tertincreases activityISOTERT (Homo sapiens)6480464CTDIsothiocyanates results in increased activity of TERT proteinPMID:23382840
Tertincreases expressionISOTERT (Homo sapiens)6480464CTDIsothiocyanates results in increased expression of TERT mRNAPMID:23382840
Tertmultiple interactionsISOTERT (Homo sapiens)6480464CTD[4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole co-treated with 1,3-benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile co-treated with U 0126] inhibits the reaction [Isothiocyanates results in increased expression of TERT mRNA]; [pyrazolanthrone co-treated with SB 203580 co-treated with U 0126] inhibits the reaction [Isothiocyanates results in increased expression of TERT mRNA]PMID:23382840
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