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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11453
Species: Mus musculus
RGD Object: Gene
Symbol: Trhr
Name: thyrotropin releasing hormone receptor
Acc ID: CHEBI:5128
Term: flurazepam
Definition: A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a 2-(diethylamino)ethyl group, 2-fluorophenyl group and chloro group at positions 1, 5 and 7, respectively. It is a partial agonist of GABAA receptors and used for the treatment of insomnia.
Chemical ID: MESH:D005479
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trhrmultiple interactionsISOTrhr (Rattus norvegicus)6480464CTDFlurazepam inhibits the reaction [TRH protein modified form binds to TRHR protein]PMID:2845442
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