Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621480
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srd5a2
Name: steroid 5 alpha-reductase 2
Acc ID: CHEBI:5062
Term: finasteride
Definition: An aza-steroid that is a synthetic drug for the treatment of benign prostatic hyperplasia.
Chemical ID: MESH:D018120
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srd5a2decreases activityISOSRD5A2 (Homo sapiens)6480464CTDFinasteride results in decreased activity of SRD5A2 proteinPMID:17218080 PMID:18644453 PMID:20359488 PMID:8689240
Srd5a2multiple interactionsISOSRD5A2 (Homo sapiens)6480464CTDFinasteride inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]; Finasteride promotes the reaction [tributyltin inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]]; tributyltin promotes the reaction [Finasteride inhibits the reaction [Testosterone results in increased expression of SRD5A2 mRNA]]PMID:23523586
Go Back to source page   Continue to Ontology report