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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10685
Species: Mus musculus
RGD Object: Gene
Symbol: Grin1
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1)
Acc ID: CHEBI:4995
Term: felbamate
Definition: The bis(carbamate ester) of 2-phenylpropane-1,3-diol. An anticonvulsant, it is used in the treatment of epilepsy.
Chemical ID: MESH:C047360
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grin1affects bindingISOGrin1 (Rattus norvegicus)6480464CTDGRIN1 protein binds to felbamatePMID:18311896
Grin1multiple interactionsISOGrin1 (Rattus norvegicus)6480464CTDfelbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2A protein]; felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2B protein]; felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2C protein]PMID:10690753
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