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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551988
Species: Mus musculus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase family, member 1
Acc ID: CHEBI:46742
Term: Nutlin-3
Definition: A Nutlin that has formula C30H30Cl2N4O4.
Chemical ID: MESH:C482205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDnutlin 3 results in increased cleavage of PARP1 proteinPMID:22260869
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTDTP53 mutant form inhibits the reaction [nutlin 3 results in increased cleavage of PARP1 protein]PMID:22260869
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