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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10991
Species: Mus musculus
RGD Object: Gene
Symbol: Nos1
Name: nitric oxide synthase 1, neuronal
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos1increases expressionISONos1 (Rattus norvegicus)6480464CTDMethotrexate results in increased expression of NOS1 mRNAPMID:37341015
Nos1multiple interactionsISONos1 (Rattus norvegicus)6480464CTDBuspirone inhibits the reaction [Methotrexate results in increased expression of NOS1 mRNA]PMID:37341015
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