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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69127
Species: Mus musculus
RGD Object: Gene
Symbol: Ccl5
Name: C-C motif chemokine ligand 5
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl5increases expressionEXP 6480464CTDCyclosporine results in increased expression of CCL5 mRNA; Cyclosporine results in increased expression of CCL5 proteinPMID:19770486 PMID:21292993 PMID:23958496 PMID:27585667
Ccl5multiple interactionsEXP 6480464CTD7-oxozeanol inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; parthenolide inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; pyrazolanthrone inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; salubrinal inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; sulforaphane inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of CCL5 mRNA]PMID:23958496 PMID:27585667
Ccl5affects expressionISOCcl5 (Rattus norvegicus)6480464CTDCyclosporine affects the expression of CCL5 proteinPMID:25051504
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