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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551988
Species: Mus musculus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase family, member 1
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageEXP 6480464CTDCyclosporine results in increased cleavage of PARP1 proteinPMID:22155090
Parp1multiple interactionsEXP 6480464CTD2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein]; Apigenin inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein]; bisindolylmaleimide I inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein]; wortmannin inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein]PMID:22155090
Parp1decreases expressionISOPARP1 (Homo sapiens)6480464CTDCyclosporine results in decreased expression of PARP1 mRNAPMID:25562108
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDCyclosporine results in increased cleavage of PARP1 proteinPMID:22155090
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTDsalubrinal inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein]PMID:22155090
Parp1multiple interactionsISOParp1 (Rattus norvegicus)6480464CTDCyclosporine inhibits the reaction [Paraquat results in increased cleavage of PARP1 protein]PMID:25947082
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