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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1342674
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARGC1A
Name: PPARG coactivator 1 alpha
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGC1Aaffects expressionEXP 6480464CTDValproic Acid affects the expression of PPARGC1A mRNAPMID:25979313
PPARGC1Adecreases expressionEXP 6480464CTDValproic Acid results in decreased expression of PPARGC1A mRNAPMID:27089845
PPARGC1Adecreases methylationEXP 6480464CTDValproic Acid results in decreased methylation of PPARGC1A genePMID:29154799
PPARGC1Aincreases expressionEXP 6480464CTDValproic Acid results in increased expression of PPARGC1A mRNAPMID:23179753 PMID:24383497 PMID:26272509 PMID:27188386 PMID:28001369 PMID:29154799
PPARGC1Amultiple interactionsEXP 6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPARGC1A mRNAPMID:27188386
PPARGC1Aincreases expressionISOPpargc1a (Mus musculus)6480464CTDValproic Acid results in increased expression of PPARGC1A mRNAPMID:24489787
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