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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11429
Species: Mus musculus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:39185
Term: thiamethoxam
Definition: An oxadiazane that is tetrahydro-N-nitro-4H-1,3,5-oxadiazin-4-imine bearing (2-chloro-1,3-thiazol-5-yl)methyl and methyl substituents at positions 3 and 5 respectively.
Chemical ID: MESH:C416660
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionISOTnf (Rattus norvegicus)6480464CTDThiamethoxam results in increased expression of TNF mRNA; Thiamethoxam results in increased expression of TNF proteinPMID:36958429
Tnfmultiple interactionsISOTnf (Rattus norvegicus)6480464CTDSilymarin inhibits the reaction [Thiamethoxam results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Thiamethoxam results in increased expression of TNF protein]PMID:36958429
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