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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346147
Species: Homo sapiens
RGD Object: Gene
Symbol: ALPL
Name: alkaline phosphatase, biomineralization associated
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ALPLdecreases activityEXP 6480464CTDCadmium Chloride results in decreased activity of ALPL proteinPMID:27558804
ALPLdecreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of ALPL mRNAPMID:22019892
ALPLmultiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in decreased expression of ALPL mRNA]; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of ALPL mRNAPMID:22019892 PMID:32522577
ALPLdecreases activityISOAlpl (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased activity of ALPL proteinPMID:31809235
ALPLdecreases expressionISOAlpl (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased expression of ALPL mRNAPMID:22209727 PMID:31809235
ALPLmultiple interactionsISOAlpl (Rattus norvegicus)6480464CTDMelatonin inhibits the reaction [Cadmium Chloride results in decreased activity of ALPL protein]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of ALPL mRNA]PMID:31809235
ALPLmultiple interactionsISOAlpl (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ALPL mRNAPMID:37325564
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