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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735622
Species: Mus musculus
RGD Object: Gene
Symbol: Gdf15
Name: growth differentiation factor 15
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gdf15decreases expressionEXP 6480464CTDDibutyl Phthalate results in decreased expression of GDF15 mRNAPMID:17361019 PMID:21266533
Gdf15increases expressionEXP 6480464CTDDibutyl Phthalate results in increased expression of GDF15 mRNAPMID:21266533
Gdf15multiple interactionsISOGDF15 (Homo sapiens)6480464CTD[Dibutyl Phthalate co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of GDF15 proteinPMID:30218697
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