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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735591
Species: Homo sapiens
RGD Object: Gene
Symbol: IL10
Name: interleukin 10
Acc ID: CHEBI:3441
Term: carvedilol
Definition: A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure.
Chemical ID: MESH:C043211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL10increases expressionEXP 6480464CTDcarvedilol results in increased expression of IL10 proteinPMID:12722941
IL10multiple interactionsEXP 6480464CTDcarvedilol inhibits the reaction [CSF2 results in increased expression of IL10 mRNA]; carvedilol inhibits the reaction [CSF2 results in increased expression of IL10 protein]PMID:12722941
IL10increases expressionISOIl10 (Rattus norvegicus)6480464CTDcarvedilol results in increased expression of IL10 mRNA; carvedilol results in increased expression of IL10 proteinPMID:16310260 PMID:18971572 PMID:20017808
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