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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347282
Species: Homo sapiens
RGD Object: Gene
Symbol: GPC4
Name: glypican 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GPC4decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of GPC4 mRNA; bisphenol A results in decreased expression of GPC4 proteinPMID:22576693 PMID:37567409 PMID:37664457
GPC4increases expressionEXP 6480464CTDbisphenol A results in increased expression of GPC4 mRNAPMID:29275510
GPC4increases methylationEXP 6480464CTDbisphenol A results in increased methylation of GPC4 genePMID:22576693
GPC4affects expressionISOGpc4 (Rattus norvegicus)6480464CTDbisphenol A affects the expression of GPC4 mRNAPMID:25181051
GPC4decreases expressionISOGpc4 (Mus musculus)6480464CTDbisphenol A results in decreased expression of GPC4 mRNAPMID:25270620
GPC4increases expressionISOGpc4 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of GPC4 mRNAPMID:30816183 PMID:32528016
GPC4increases expressionISOGpc4 (Mus musculus)6480464CTDbisphenol A results in increased expression of GPC4 mRNAPMID:30951980 PMID:35598803
GPC4multiple interactionsISOGpc4 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of GPC4 mRNA; [bisphenol A co-treated with Estradiol] results in increased expression of GPC4 mRNAPMID:26496021 PMID:36041667
GPC4multiple interactionsISOGpc4 (Mus musculus)6480464CTD[bisphenol A co-treated with Tretinoin] results in decreased expression of GPC4 mRNAPMID:30951980
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