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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733100
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2
Name: BCL2 apoptosis regulator
Acc ID: CHEBI:32888
Term: gamma-hexachlorocyclohexane
Definition: A cyclodiene organochlorine insecticide that has formula C6H6Cl6.
Chemical ID: MESH:D001556
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2decreases expressionEXP 6480464CTDHexachlorocyclohexane results in decreased expression of BCL2 proteinPMID:14688026
BCL2increases expressionEXP 6480464CTDHexachlorocyclohexane results in increased expression of BCL2 mRNA; Hexachlorocyclohexane results in increased expression of BCL2 proteinPMID:14688026 PMID:18174961
BCL2multiple interactionsEXP 6480464CTD[Hexachlorocyclohexane co-treated with Estradiol] results in increased expression of BCL2 proteinPMID:18174961
BCL2multiple interactionsISOBcl2 (Rattus norvegicus)6480464CTDHexachlorocyclohexane promotes the reaction [BECN1 protein binds to BCL2 protein]PMID:19041923
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